Self-rated health in Europe and its determinants: Does generation matter?

Objectives: To analyse the influence of micro- and macro-factors on self-rated health, and the role of generation on this relationship. Methods: Cross-sectional study using data from European Health Interview Surveys from 14 European countries. Individuals were divided into four generations (“silent generation”, “baby boomers”, and “generation X” and “Y”). We conducted multilevel analyses for each generation to study the influence of individual and national explanatory variables on self-rated health. Results: Age showed an exponential effect in older generations. Education and employment presented the strongest association with low self-rated health, especially in “baby boomers” and women (low education: OR 3.5; 95% CI 3.2–3.9). Tobacco showed a negative effect in younger generations. Overweight and low physical activity were negatively associated with self-rated health regardless of generation. Countries from the Eastern welfare system showed the highest risk of low self-rated health and this association was higher in men for “silent generation” (OR 4.7; 95% CI 3.0–7.6). Conclusions: The influence of individual and national factors on self-rated health varies regarding generation. The target generation and the demographic structure of a country should be taken into account to develop more accurate health policies

Recession, employment and self-rated health: a study on the gender gap

Objectives: Employment status and economic recession have been associated with negative effects on self-rated health, and this effect differs by gender. We analysed the effects of the Spanish economic recession in terms of self-rated health, its differential effect among genders and its influence on gender gap. Study design: Repeated cross-sectional study using Spanish health surveys (2001–2014). Methods: Logistic regression models were conducted to explore the association between self-rated health and employment status and its evolution over time and gender. To test the impact of the economic recession, pooled data regression models were conducted. Results: In this study, we considered 104,577 subjects. During the last 15 years, women have entered the labour market, leading to wide changes in the Spanish traditional family roles. Instead of an increasing proportion of women workers, gender employment differences persist. Therefore, in 2014, the prevalence of workers was 55.77% in men, whereas in women, it was 44.01%. Self-rated health trends during the economic recession differ by gender, with women improving slightly their self-rated health from a low self-rated health prevalence of 38.76% in 2001 to 33.78% in 2014. On the contrary, men seem more vulnerable to employment circumstances, which have led to substantial reduction in the gender gap. Conclusions: Although a gender gap persists, the change in socio-economic roles seems to increase women's self-rated health, reducing this gap. It is important to promote women's labour market inclusion, even in economic recession periods

Singular sources in the Demianski-Newman spacetimes

The analysis of singular regions in the NUT solutions carried out in the recent paper (Manko and Ruiz, 2005 Class. Quantum Grav. 22, p.3555) is now extended to the Demianski-Newman vacuum and electrovacuum spacetimes. We show that the effect which produces the NUT parameter in a more general situation remains essentially the same as in the purely NUT solutions: it introduces the semi-infinite singularities of infinite angular momenta and positive or negative masses depending on the interrelations between the parameters; the presence of the electromagnetic field additionally endows the singularities with electric and magnetic charges. The exact formulae describing the mass, charges and angular momentum distributions in the Demianski-Newman solutions are obtained and concise general expressions P_n=(m+i\nu)(ia)^n, Q_n=(q+ib)(ia)^n for the entire set of the respective Beig-Simon multipole moments are derived. These moments correspond to a unique choice of the integration constant in the expression of the metric function \omega which is different from the original choice made by Demianski and Newman.Comment: 22 pages, 5 figures; submitted to Classical and Quantum Gravit

Mean Sombor index

A Special Volume on Chemical Graph Theory in Memory of Nenad TrinajsticWe introduce a degree–based variable topological index inspired on the power (or generalized) mean. We name this new index as the mean Sombor index: SOα(G) = P uv∈E(G) [(d α u + d α v ) /2]1/α. Here, uv denotes the edge of the graph G connecting the vertices u and v, du is the degree of the vertex u, and α ∈ R\{0}. We also consider the limit cases mSOα→0(G) and SOα→±∞(G). Indeed, for given values of α, the mean Sombor index is related to well-known opological indices such as the inverse sum indeg index, the reciprocal Randic index, the first Zagreb index, the Stolarsky–Puebla index and several ´Sombor indices. Moreover, through a quantitative structure property relationship (QSPR) analysis we show that mSOα(G) correlates well with several physicochemical properties of octane isomers. Some mathematical properties of the mean Sombor index as well as bounds and new relationships with known topological indices are also discussed.J.A.M.-B. acknowledges financial support from CONACyT (Grant No. A1-S-22706) and BUAP (Grant No. 100405811VIEP2021) .E.D.M. and J.M.R. were supported by a grant from Agencia Estatal de Investigación (PID 2019-106433GBI00 / AEI / 10.13039 / 501100011033), Spain. J.M.R. was supported by the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with UC3M in the line of Excellence of University Professors (EPUC3M23), and in the context of the VPRICIT (Regional Programme of Research and Technological Innovation)

Integrating clinical research in an operative screening and diagnostic breast imaging department: First experience, results and perspectives using microwave imaging.

Clinical research is crucial for evaluating new medical procedures and devices. It is important for healthcare units and hospitals to minimize the disruptions caused by conducting clinical studies; however, complex clinical pathways require dedicated recruitment and study designs.This work presents the effective introduction of novel microwave breast imaging (MBI), via MammoWave apparatus, into the clinical routine of an operative screening and diagnostic breast imaging department for conducting a multicentric clinical study. Microwave breast imaging, using MammoWave apparatus, was performed on volunteers coming from different clinical pathways. Clinical data, comprising demographics and conventional radiologic reports (used as reference standard), was collected; a satisfaction questionnaire was filled by every volunteer. Microwave images were analyzed by an automatic clinical decision support system, which quantified their corresponding features to discriminate between breasts with no relevant radiological findings (NF) and breasts with described findings (WF). Conventional breast imaging (DBT, US, MRI) and MBI were performed and adapted to assure best clinical practices and optimum pathways. 180 volunteers, both symptomatic and asymptomatic, were enrolled in the study. After microwave images' quality assessment, 48 NF (15 dense) and 169 WF (88 dense) breasts were used for the prospective study; 48 (18 dense) breasts suffered from a histology-confirmed carcinoma. An overall sensitivity of 85.8 % in breasts lesions' detection was achieved by the microwave imaging apparatus. An optimum recruitment strategy was implemented to assess MBI. Future trials may show the clinical usefulness of microwave imaging, which may play an important role in breast screening. [Abstract copyright: © 2023 The Authors.

On interrelations between Sibgatullin's and Alekseev's approaches to the construction of exact solutions of the Einstein-Maxwell equations

The integral equations involved in Alekseev's "monodromy transform" technique are shown to be simple combinations of Sibgatullin's integral equations and normalizing conditions. An additional complex conjugation introduced by Alekseev in the integrands makes his scheme mathematically inconsistent; besides, in the electrovac case all Alekseev's principal value integrals contain an intrinsic error which has never been identified before. We also explain how operates a non-trivial double-step algorithm devised by Alekseev for rewriting, by purely algebraic manipulations and in a different (more complicated) parameter set, any particular specialization of the known analytically extended N-soliton electrovac solution obtained in 1995 with the aid of Sibgatullin's method.Comment: 7 pages, no figures, section II extende

Understanding the effect of economic recession on healthcare services: a systematic review

Background: We aimed to examine the available evidence about the impact of the crisis on the use of healthcare services in Europe. Methods: We developed a systematic review of scientific literature for the period 2008-2017. The researchers searched three databases Medline/PubMed, Scopus and Web of Knowledge. For manual searching, several spe-cialized journals of related scope as well as the finalized articles'' reference list were searched. Descriptive and thematic analyses were carried out. PRISMA quality criteria and the recommendations of the Centre for Reviews and Dissemination were followed. Results: Of 3, 685 studies, 35 met inclusion criteria. Regarding “Effects of the social structure” healthcare accessibility inequalities increased by socioeconomic levels, especially in unemployed, people with low educational levels and migrants. Regarding “Healthcare effect”, the impact of the recession was observed in unmet needs, pharmaceutical spending containment, reduction of hospital beds, and privatization of services. Conclusion: Austerity policies have contributed to increasing inequalities in the use of health services during the economic downturn. In the current economic climate, new management and health planning strategies such as hospitalisation at home, new models of integrated care and pharmaceutical management are needed to help achieve greater equity and equality in health

Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) (PHBV)/MBGN Composite Microspheres

In recent years, composite biomaterials have attracted attention for drug delivery applications due to the possibility of combining desired properties of their components. However, some functional characteristics, such as their drug release efficiency and likely side effects, are still unexplored. In this regard, controlled tuning of the drug release kinetic via the precise design of a composite particle system is still of high importance for many biomedical applications. This objective can be properly fulfilled through the combination of different biomaterials with unequal release rates, such as mesoporous bioactive glass nanoparticles (MBGN) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres. In this work, MBGNs and PHBV-MBGN microspheres, both loaded with Astaxanthin (ASX), were synthesised and compared in terms of ASX release kinetic, ASX entrapment efficiency, and cell viability. Moreover, the correlation of the release kinetic to phytotherapeutic efficiency and side effects was established. Interestingly, there were significant differences between the ASX release kinetic of the developed systems, and cell viability differed accordingly after 72 h. Both particle carriers effectively delivered ASX, though the composite microspheres exhibited a more prolonged release profile with sustained cytocompatibility. The release behaviour could be fine-tuned by adjusting the MBGN content in the composite particles. Comparatively, the composite particles induced a different release effect, implying their potential for sustained drug delivery applications.Fil: Aguilar Rabiela, Arturo E.. Universitat Erlangen-Nuremberg; AlemaniaFil: Homaeigohar, Shahin. University Of Dundee; Reino UnidoFil: González Castillo, Eduin I.. No especifíca;Fil: Sanchez, Mirna Lorena. Universitat Erlangen-Nuremberg; Alemania. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Farmacología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemani

Economic Analysis of a Pediatric Ventilator-Associated Pneumonia Prevention Initiative in Nicaragua

We performed an economic analysis of an intervention to decrease ventilator-associated pneumonia (VAP) prevalence in pediatric intensive care units (PICUs) at two Nicaraguan hospitals to determine the cost of the intervention and how effective it needs to be in order to be cost-neutral. A matched cohort study determined differences in costs and outcomes among ventilated patients. VAP cases were matched by sex and age for children older than 28 days and by weight for infants under 28 days old to controls without VAP. Intervention costs were determined from accounting and PICU staff records. The intervention cost was approximately $7,000 for one year. If VAP prevalence decreased by 0.5$7,000 and the strategy would be cost-neutral. The finding that the intervention required only modest effectiveness to be cost-neutral and has potential to generate substantial cost savings argues for implementation of VAP prevention strategies in low-income countries like Nicaragua on a broader scale