A Review of the Role of Melatonin in Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a troubling disease experienced worldwide. The presentation of symptoms varies from patient to patient, and current prescription treatments can be inadequate in resolving symptoms. This article explores the available scientific literature supporting the use of melatonin in alleviating IBS symptoms

Accretion disc-corona and jet emission from the radio-loud narrow-line Seyfert 1 galaxy RX J1633.3+4719

We perform X-ray/ultraviolet (UV) spectral and X-ray variability studies of the radio-loud narrow-line Seyfert 1 (NLS1) galaxy RX J1633.3+4719 using XMM-Newton and Suzaku observations from 2011 and 2012. The 0.3-10 keV spectra consist of an ultrasoft component described by an accretion disc blackbody (kT_in = 39.6^{+11.2}_{-5.5} eV) and a power law due to the thermal Comptonization ({\Gamma} = 1.96^{+0.24}_{-0.31}) of the disc emission. The disc temperature inferred from the soft excess is at least a factor of 2 lower than that found for the canonical soft excess emission from radio-quiet NLS1s. The UV spectrum is described by a power law with photon index 3.05^{+0.56}_{-0.33}. The observed UV emission is too strong to arise from the accretion disc or the host galaxy, but can be attributed to a jet. The X-ray emission from RX J1633.3+4719 is variable with fractional variability amplitude $F_{\rm var}$=13.5$\pm1.0$ per cent. In contrast to radio-quiet active galactic nuclei (AGN), X-ray emission from the source becomes harder with increasing flux. The fractional rms variability increases with energy and the rms spectrum is well described by a constant disc component and a variable power-law continuum with the normalization and photon index being anticorrelated. Such spectral variability cannot be caused by variations in the absorption and must be intrinsic to the hot corona. Our finding of possible evidence for emission from the inner accretion disc, jet and hot corona from RX J1633.3+4719 in the optical to X-ray bands makes this object an ideal target to probe the disc-jet connection in AGN.Comment: 12 pages, 11 figures, 3 tables, Published in MNRA

Embedded AGN and star formation in the central 80 pc of IC 3639

[Abridged] Methods: We use interferometric observations in the $N$-band with VLTI/MIDI to resolve the mid-IR nucleus of IC 3639. The origin of the nuclear infrared emission is determined from: 1) the comparison of the correlated fluxes from VLTI/MIDI with the fluxes measured at subarcsec resolution (VLT/VISIR, VLT/ISAAC); 2) diagnostics based on IR fine-structure line ratios, the IR continuum emission, IR bands produced by polycyclic aromatic hydrocarbons (PAH) and silicates; and 3) the high-angular resolution spectral energy distribution. Results: The unresolved flux of IC 3639 is $90 \pm 20\, \rm{mJy}$ at $10.5\, \rm{\mu m}$, measured with three different baselines in VLTI (UT1-UT2, UT3-UT4, and UT2-UT3; $46$-$58\, \rm{m}$), making this the faintest measurement so far achieved with mid-IR interferometry. The correlated flux is a factor of $3$-$4$ times fainter than the VLT/VISIR total flux measurement. The observations suggest that most of the mid-IR emission has its origin on spatial scales between $10$ and $80\, \rm{pc}$ ($40$-$340\, \rm{mas}$). A composite scenario where the star formation component dominates over the AGN is favoured by the diagnostics based on ratios of IR fine-structure emission lines, the shape of the IR continuum, and the PAH and silicate bands. Conclusions: A composite AGN-starburst scenario is able to explain both the mid-IR brightness distribution and the IR spectral properties observed in the nucleus of IC 3639. The nuclear starburst would dominate the mid-IR emission and the ionisation of low-excitation lines (e.g. [NeII]$_{12.8 \rm{\mu m}}$) with a net contribution of $\sim 70\%$. The AGN accounts for the remaining $\sim 30\%$ of the mid-IR flux, ascribed to the unresolved component in the MIDI observations, and the ionisation of high-excitation lines (e.g. [NeV]$_{14.3 \rm{\mu m}}$ and [OIV]$_{25.9 \rm{\mu m}}$).Comment: Accepted for publication in A&

Heavy boson production through the collision of an ultrahigh-energy neutrino on a target nucleon

We discuss W and Z production through the deep inelastic neutrino-nucleon scattering in the context of the standard model SU(3)x SU(2)x U(1) of the strong and electroweak interactions. We find the cross section rates for the process neutrino + nucleon --> lepton(-) + W(+) + X for the case of ultrahigh-energy neutrinos colliding on a target nucleon.Comment: 20 pages, 6 figure

Experiments on the culture of Penaeus monodon in the salt pan area at Tuticorin

The paper embodies the results of growth and production of Penaeus monodon cultured during 1988-89 in the salt pan area at Tuticorin. The overall growth rate of the hatchery produced seeds stocked in ponds varied from 25.1 mm/5.85 g to 35.2 mm/9.8g per month and the best growth was associated with low stocking density. The post-larvae attained marketable size of 32 g in about 140 days. Supplementary feed consisted of 7-9 ingredients with protein value of 38%. The conversion ratio varied from 1:1:5 to 1:1.91

Muon Pair Production by Electron-Photon Scatterings

The cross section for muon pair productions by electrons scattering over photons, $\sigma_{MPP}$, is calculated analytically in the leading order. It is pointed out that for the center-of-mass energy range, $s \geq 5 m^{2}_{\mu}$, the cross section for $\sigma_{MPP}$ is less than $1 \mu$b. The differential energy spectrum for either of the resulting muons is given for the purpose of high-energy neutrino astronomy. An implication of our result for a recent suggestion concerning the high-energy cosmic neutrino generation through this muon pair is discussed.Comment: a comment added, to appear in Phys. Rev. D, Rapid Communicatio

Thresholded Covering Algorithms for Robust and Max-Min Optimization

The general problem of robust optimization is this: one of several possible scenarios will appear tomorrow, but things are more expensive tomorrow than they are today. What should you anticipatorily buy today, so that the worst-case cost (summed over both days) is minimized? Feige et al. and Khandekar et al. considered the k-robust model where the possible outcomes tomorrow are given by all demand-subsets of size k, and gave algorithms for the set cover problem, and the Steiner tree and facility location problems in this model, respectively. In this paper, we give the following simple and intuitive template for k-robust problems: "having built some anticipatory solution, if there exists a single demand whose augmentation cost is larger than some threshold, augment the anticipatory solution to cover this demand as well, and repeat". In this paper we show that this template gives us improved approximation algorithms for k-robust Steiner tree and set cover, and the first approximation algorithms for k-robust Steiner forest, minimum-cut and multicut. All our approximation ratios (except for multicut) are almost best possible. As a by-product of our techniques, we also get algorithms for max-min problems of the form: "given a covering problem instance, which k of the elements are costliest to cover?".Comment: 24 page