New Aquatic Beetle Records for Canada (Coleoptera: Haliplidae, Dytiscidae)

Three species of aquatic beetle, Peltodytes simplex (LeConte) (Haliplidae), Agabus oblongulus Fall (Dytiscidae) (both from southern British Columbia) and Ilybius oblitus Sharp (Dytiscidae) (from southern Ontario) are confirmed as members of the Canadian fauna based on specimens deposited in the Spencer Entomological Museum at the University of British Columbia

Paranoid and misidentification subtypes of psychosis in dementia

This study aimed to review the neurobiological and neuropsychological correlates of paranoid (persecutory delusions) and misidentification (misidentification delusions and/or hallucinations) subtypes of psychosis in dementia, to establish if they represent distinct subphenotypes. Nine studies were eligible, all included patients with Alzheimer’s disease. Greater global cognitive deficits and an accelerated global cognitive decline were observed in the misidentification subtype. Neuroimaging studies showed more marked volume loss in multiple regions in patients with the misidentification subtype, including those involved in object recognition and the processing of information on spatial and temporal context. A single study found greater impairment in visual sustained attention and object recognition in the misidentification subtype. The small number of studies and methodological heterogeneity limit interpretation of the findings. Nevertheless, these findings would tentatively suggest that there may be additional or accelerated pathological change in functional networks involved in visuoperceptual processing in the misidentification subtype. This should be further explored in prospective studies and the investigation extended to other forms of dementia, to gain a transdiagnostic perspective

In Search of Robert Bruce, Part I: Craniofacial Analysis of the Skull excavated at Dunfermline in 1819

Robert Bruce, king of Scots, is a significant figure in Scottish history, and his facial appearance will have been key to his status, power and resilience as a leader. This paper is the first in a series that discusses the burial and skeletal remains excavated at Dunfermline in 1819. Parts II and III discuss the evidence relating to whether or not the burial vault and skeleton belong to Robert Bruce, and Part I analyses and interprets the historical records and skeletal structure in order to produce a depiction of the facial appearance of Robert Bruce

Growth of Trifolium subterraneum L. Selected for Sparse and Abundant Nodulation as Affected by Root Temperature and Rhizobium Strain

RESP-625

Antimicrobial animals

We are living in a time of enormous risk. Years of antibiotic overuse and misuse has contributed to a global threat, where an increase in antibiotic resistant bacteria are contributing to approximately 700,000 deaths per year. International institutions such as the World Health Organization (WHO) and the UK government are calling for new antibiotics and strategies to combat resistance (Tagliabue & Rappuoli, 2018). Antibiotic resistance occurs when bacteria adapt to antimicrobial drugs. These bacteria are often referred to as “superbugs”, and the drugs used to treat them become ineffective, infections persist in the body, and the risk of spread to others increases (World Health Organization, 2018). Superbugs are negatively contributing to our healthcare system‘s ability to treat patients effectively and the world urgently needs to change the way it prescribes and uses antibiotics. Unless new antibiotics or alternative strategies are developed to cope with this problem, society will no longer able to routinely use certain antibiotics. The simplest of medical procedures will also become life threatening

Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation : application to studies of human link protein cleavage by stromelysin

Monoclonal antibodies were raised that specifically recognize the NH2-terminal neoepitope sequence present in like protein cleavage products derived from stromelysin-degraded proteoglycan aggregate. Competitive enzyme-linked immunosorbend assay, using synthetic peptides as inhibitors, showed that one of these antibodies (CH-3) required, for antibody recognition, the free NH2-terminal amino acid isoleucine (residue 17 of the intact protein) in the sequence NH2-IQAENG at the stromelysin cleavage site of link protein 3.Monoclonal antibodies were raised that specifically recognize the NH2-terminal neoepitope sequence present in like protein cleavage products derived from stromelysin-degraded proteoglycan aggregate. Competitive enzyme-linked immunosorbend assay, using synthetic peptides as inhibitors, showed that one of these antibodies (CH-3) required, for antibody recognition, the free NH2-terminal amino acid isoleucine (residue 17 of the intact protein) in the sequence NH2-IQAENG at the stromelysin cleavage site of link protein 3