Fluconazole and boric acid for treatment of vaginal candidiasis- New words about old issue

Objective: To compare boric acid as an effective treatment for VVC  compared to fluconazole. We also studied the efficiency of these drugs in preventing recurrence of VVC.Design: A cross sectional, randomized, double-blind study.Settings: Gynaecology clinic of Imam Reza hospital, Tehran - IranSubjects: Women with signs and symptoms related to Vulvo Vaginal Candidiasis.Results: Seventy five patients out of total 150 patients with signs and symptoms related to Vulvo Vaginal Candidiasis were treated with boric acid powder every night for a week and the remaining 75 patients received Fluconazole. The cure rate in first group was 46.7% but the cure rate in second group was 37.3%. The difference was not statistically significant (P>0.3). Difference between the efficacy of the two drugs was not  significant either (P=0.47). The recurrence rate among patients in first group was 35% while it was 32% in second group. Their difference was not statistically significant (P=0.54).Conclusion: According to our findings, treatment of vaginal candidiasis with boric acid is as effective as fluconazole. The availability of boric acid and its relatively low cost suggests it as a safe and effective drug for treatment of candidiasis

A Concise Formula for Two Dimensional Divided Differences with Multiple Knots

The well-known formulas for divided differences in the case of one and two dimensional with multiple knots have played an important role in applied mathematics, particularly in numerical analysis, polynomial and lagrange interpolations. In this article we obtain a new formula for two dimensional divided differences in the case of multiple knots. This formula has a simpler form than the known formula given in literature. It is friendly using for computations and analysis

In vitro Osteogenic impulse effect of Dexamethasone on periodontal ligament stem cells

Periodontium is a complex organ composed of mineralized epithelial and connective tissue. Dexamethasone could stimulate proliferation of osteoblast and fibroblasts. This study aimed to assess the osteogenic effect of dexamethasone on periodental ligament (PDL) stem cells. PDL stem cells were collected from periodontal ligament tissue of root of extracted premolar of young and healthy people. The stem cells were cultured in alpha-MEM Medium in three groups, one group with basic medium contains (alpha-MEM and FBS 10 and 50 mmol of beta gelisrophosphat and L ascorbic acid mu g/ml), the second group: basic medium with dexamethasone and the third one: basic medium without any osteogenic stimulant. Mineralization of cellular layer was analyzed with Alizarin red stain method. Osteogenic analysis was done by Alkaline phosphates and calcium test. These analysis indicated that the amount of intra-cellular calcium and alkaline phosphates in the Dexamethasone group was far more than the control and basic group (P<0.05). The results of Alizarin red stain indicated more mineralization of cultured cells in Dexamethasone group (P<0.05). The study results showed that Dexamethasone has significant osteogenic effect on PDL stem cells and further studies are recommended to evaluate its effect on treatment of bone disorders

The prevalence of the localized aggressive periodontitis among students at 14-16 years in Ilam, Iran

The localized aggressive periodontitis, called an early onset periodontitis, is periodontal tissue destruction that symptoms appear at adolescence and youth that the prevalence of it is different in different areas. The crosssectional present study was done by two-step method on 1000 individuals at 14-16 years high school students. The examination was done in two parts. After isolating samples at office school in normal light, overthrow of the lips and cheeks by tongue blade or mirror examination, the pockets of mesiobuccal, mesiolingual, distobuccal, distolingual, buccal and lingual of first molar and incisors of both jaw were measured by Williams probe. In step two the suspicious student invited to clinic for more diagnosis. Other information was collected by Questionnaire. There were 500 boys and 500 girls that were examined. In the first step of examination, the 32 individuals who suspected were isolated. In the second examination, the 7 persons isolated as patient. The prevalence of that was 0.7 in population. ). The prevalence divided into 0.3 females and 0.4& males. By Chi-square was determined that there wasn't any significant relationship about gender (p>0.05). In respect of 0.7 prevalence for local aggressive periodontitis in Ilam, Iran and the prevalence around the world about 0.1-0.3, it can concluded that Ilam has the more prevalence and it needs more healthy services attention

Study of the inhibitory effect of Quercus Coccifera's aqueous extract on Staphylococcus aureus and Pseudomonas aeruginosa In vitro

The use of therapeutic herbs has become of great importance these days due to the increase in drug resistance. From a long time ago the Venus' navel plant has been used to treat infections. In this study the antibacterial effect of the aqueous extract from the Quercus coccifera (jaft) herb, under laboratory conditions. This study was carried out experimentally. After collecting the Venus navel herb, it was dried in a warm dry environment away from direct sunlight in the shade. The alcoholic extract was prepared using a standard method. Clinical samples of staphylococcus aureus and pseudomonas aeruginosa were acquired from Ilam's health care institutes. The inhibitory effect of the extracts was analysed in the Mueller Hinton using the disk diffusion method for both bacteria. Then MIC and MBC of the extracts was determined using the Macro broth dilution method. At its highest concentration the aqueous extract had an inhibition zone of 27.2 and 23.7 mm on staphylococcus aureus and pseudomonas aeruginosa consecutively. The MIC and MBC for staphylococcus aureus were 10 and 12.5 microg/ml and for pseudomonas aeruginosa they were 10 and 17.5 microg/m consecutively. The results of this study show the strong antimicrobial effect of jaft's aqueous extract on staphylococcus aureus and pseudomonas aeruginosa and if more studies are based on this topic it could be a substitute for common antibiotics

Antimicrobial effect of Pistacia atlantica leaf extract

The antimicrobial effect of the mastic tree (Pistacia atlantica) under in vitro conditions has been reported. Therefore, it is of interest to evaluate the effect of the plant leaf extract (aqueous) on bacterial load in mouth and saliva. The leaf of the Pistacia atlantica plant was collected and cleaned, dried at 40 degrees c and then powdered. The extraction was carried out using the maceration method in vacuum with the rotary evaporator device. Bacterial inhibition (Streptococcus species) by the leaf extract was studied using the disc diffusion and embedding sink diffusion methods. The values of MIC and MBC were determined. The collected data was further analyzed using t-test and repeated measure statistical tests. The disc diffusion technique showed a significant inhibitory effect for Pistacia atlantica's leaf extract on S. mutans (ATCC 35668) and S. mitis (ATCC 49456) with inhibition zones of 19 and 25 millimeters, respectively. This is for the highest leaf extract concentration used in this study (p<0.01). The values of MIC and MBC for S. mutans was 60, 90 mu g/ml and for S. mitis was 75, 110 mu g/ml (p<0.01 significance). The leaf extract has no significant effect on S. salivarius (ATCC 13419). Thus, the antimicrobial properties of the aqueous leaf extract from Pistacia atlantica is demonstrated in this study