Accumulation of Osmoprotectants Acclimating Proso millet (Panicum miliaceum L.) to Drought Stress Tolerance

Drought is one of the environmental stressors that limits plant growth, production, and is a great threat to the rising population and security throughout the globe. In the present work, we aimed to check the impact of drought stress given at different days interval drought (DID) on proso millet and its tolerance capability. The pot culture experiment was conducted and drought stress was given at 3 DID, 5 DID, and 7 DID respectively, and sampling was done on 15, 30, and 60 DAS, and unstressed plants were irrigated regularly. Drought stress results in decreased protein contents in both the roots and shoots of P. miliaceum on all sampling days. However, with increasing drought intensity and duration there was a tremendous increase in amino acids, and proline contents as well. Therefore, increasing osmolytes like proline with an increased drought period proves the role of proline in stress tolerance of proso millet and helps it to survive by maintaining osmotic potential, water influx, and detoxifying ROS. Thus, proso millet can be cultivated in drought-prone areas, and used for the breeding program

Emulating On-Orbit Interactions Using Forward Dynamics Based Cartesian Motion

The paper presents a novel Hardware-In-the-Loop (HIL) emulation framework of on-orbit interactions using on-ground robotic manipulators. It combines Virtual Forward Dynamic Model (VFDM) for Cartesian motion control of robotic manipulators with an Orbital Dynamics Simulator (ODS) based on the Clohessy Wiltshire (CW) Model. VFDM-based Inverse Kinematics (IK) solver is known to have better motion tracking, path accuracy, and solver convergency than traditional IK solvers. Therefore it provides a stable Cartesian motion for manipulator-based HIL on-orbit emulations. The framework is tested on a ROS-based robotics testbed to emulate two scenarios: free-floating satellite motion and free-floating interaction (collision). Mock-ups of two satellites are mounted at the robots' end-effectors. Forces acting on the mock-ups are measured through an in-built F/T sensor on each robotic arm. During the tests, the relative motion of the mock-ups is expressed with respect to a moving observer rotating at a fixed angular velocity in a circular orbit rather than their motion in the inertial frame. The ODS incorporates the force and torque values on the fly and delivers the corresponding satellite motions to the virtual forward dynamics model as online trajectories. Results are comparable to other free-floating HIL emulators. Fidelity between the simulated motion and robot-mounted mock-up motion is confirmed.Comment: Submitted to ICRA2023, for associated video, see: https://www.youtube.com/watch?v=N2KYCKJ4KM

Caputo fractional MHD casson fluid flow over an oscillating plate with thermal radiation

The effect of the thermal radiation on the MHD Casson fluid along with the fractional derivative in an oscillating vertical plate is elucidated. More exactly, the Caputo fractional model is utilized in developing the governing equations. Besides, the influence of the buoyancy force due to the temperature gradient has also been considered. The derived fractional partial differential equations are converted into ordinary differential equations by using the Laplace transform technique and then are solved for analytical solutions via the characteristic method. The inversion of the Laplace transformation is obtained through the numerical approach of Zakian. The effects of various physical parameters on the velocity and temperature profiles, Nusselt number, and skin friction have been analyzed and depicted in graphs and tables. The distribution of the velocity and temperature either in viscous or Casson fluid do enhance by the fractional parameter

Neuromuscular disease genetics in under-represented populations: increasing data diversity

\ua9 The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain. Neuromuscular diseases (NMDs) affect ∼15 million people globally. In high income settings DNA-based diagnosis has transformed care pathways and led to gene-specific therapies. However, most affected families are in low-to-middle income countries (LMICs) with limited access to DNA-based diagnosis. Most (86%) published genetic data is derived from European ancestry. This marked genetic data inequality hampers understanding of genetic diversity and hinders accurate genetic diagnosis in all income settings. We developed a cloud-based transcontinental partnership to build diverse, deeply-phenotyped and genetically characterized cohorts to improve genetic architecture knowledge, and potentially advance diagnosis and clinical management. We connected 18 centres in Brazil, India, South Africa, Turkey, Zambia, Netherlands and the UK. We co-developed a cloud-based data solution and trained 17 international neurology fellows in clinical genomic data interpretation. Single gene and whole exome data were analysed via a bespoke bioinformatics pipeline and reviewed alongside clinical and phenotypic data in global webinars to inform genetic outcome decisions. We recruited 6001 participants in the first 43 months. Initial genetic analyses \u27solved\u27 or \u27possibly solved\u27 ∼56% probands overall. In-depth genetic data review of the four commonest clinical categories (limb girdle muscular dystrophy, inherited peripheral neuropathies, congenital myopathy/muscular dystrophies and Duchenne/Becker muscular dystrophy) delivered a ∼59% \u27solved\u27 and ∼13% \u27possibly solved\u27 outcome. Almost 29% of disease causing variants were novel, increasing diverse pathogenic variant knowledge. Unsolved participants represent a new discovery cohort. The dataset provides a large resource from under-represented populations for genetic and translational research. In conclusion, we established a remote transcontinental partnership to assess genetic architecture of NMDs across diverse populations. It supported DNA-based diagnosis, potentially enabling genetic counselling, care pathways and eligibility for gene-specific trials. Similar virtual partnerships could be adopted by other areas of global genomic neurological practice to reduce genetic data inequality and benefit patients globally

Neuromuscular disease genetics in under-represented populations: increasing data diversity

Neuromuscular diseases (NMDs) affect ∼15 million people globally. In high income settings DNA-based diagnosis has transformed care pathways and led to gene-specific therapies. However, most affected families are in low-to-middle income countries (LMICs) with limited access to DNA-based diagnosis. Most (86%) published genetic data is derived from European ancestry. This marked genetic data inequality hampers understanding of genetic diversity and hinders accurate genetic diagnosis in all income settings. We developed a cloud-based transcontinental partnership to build diverse, deeply-phenotyped and genetically characterized cohorts to improve genetic architecture knowledge, and potentially advance diagnosis and clinical management. We connected 18 centres in Brazil, India, South Africa, Turkey, Zambia, Netherlands and the UK. We co-developed a cloud-based data solution and trained 17 international neurology fellows in clinical genomic data interpretation. Single gene and whole exome data were analysed via a bespoke bioinformatics pipeline and reviewed alongside clinical and phenotypic data in global webinars to inform genetic outcome decisions. We recruited 6001 participants in the first 43 months. Initial genetic analyses ‘solved’ or ‘possibly solved’ ∼56% probands overall. In-depth genetic data review of the four commonest clinical categories (limb girdle muscular dystrophy, inherited peripheral neuropathies, congenital myopathy/muscular dystrophies and Duchenne/Becker muscular dystrophy) delivered a ∼59% ‘solved’ and ∼13% ‘possibly solved’ outcome. Almost 29% of disease causing variants were novel, increasing diverse pathogenic variant knowledge. Unsolved participants represent a new discovery cohort. The dataset provides a large resource from under-represented populations for genetic and translational research. In conclusion, we established a remote transcontinental partnership to assess genetic architecture of NMDs across diverse populations. It supported DNA-based diagnosis, potentially enabling genetic counselling, care pathways and eligibility for gene-specific trials. Similar virtual partnerships could be adopted by other areas of global genomic neurological practice to reduce genetic data inequality and benefit patients globally

Dar in “Machine crushed animal bones as partial replacement of coarse aggregates in lightweight concrete

ABSTRACT An exploratory study on the suitability of the machine crushed animal bones as partial or full replacement for normal coarse aggregates in concrete works has been carried out. Physical and mechanical properties of machine crushed animal bones and locally available normal aggregate have been determined and compared. A large number of concrete cubes of size 150×150×50 mm with different percentages by weight of normal aggregate to crushed animal bones as coarse aggregate in the order 100:0, 75:25, 65:35, 50:50, 25:75 and 0:100 were cast, tested and their physical and mechanical properties were determined. Compressive strength tests showed that approximately 50% of the crushed animal bones in replacement for normal aggregate were quite satisfactory with no compromise in compressive strength requirements for concrete mix ratio 1:1.5:3. The study has been carried out at 25%, 35%, 50%, 75%, and 100% replacement levels of normal aggregate by crushed animal bone (CAB) aggregate by weight and a comparative study has been done between normal concrete and crushed animal bone (CAB) concrete

Diagnostic Accuracy of MRI in Internal Derangement of Knee in Comparison to Arthroscopy MRI Vs Arthroscopy in Knee Injury

Background: The knee joint (KJ) is one of the largest as well as most complicated joints in the human body. The knee is one of the most frequently injured joints, either as a separated injury or as a common portion in patients with multiple traumas. MRI has completely transformed the field of radio diagnosis because it provides superior soft tissue (ST) contrast. Also, it has appeared to be highly useful in muscle, brain, abdominal, and soft tissue imaging. The MRI is non-invasive which provides significantly better ST contrast, and requires less imaging time while having fewer artefacts. Aims & Objectives: To compare the accuracy of diagnostic [True Positive (TP), True Negative (TN), False Positive (FP), as well as False Negative (FN)] of MRI & arthroscopy in diagnosing internal derangement (ID) of the knee. To determine the function of MRI in selecting patients for arthroscopy. Material and Methods: This research is a cross-sectional investigation wherein patients who were thought to have an internal knee dislocation (IKD) were given an MRI and some were chosen for an arthroscopy. Most MRIs were done on a 1.5 tesla MRI scanner. The results of the MRI were written down.&nbsp

Hemodynamic Evaluation of Coarctation of Aorta Using Phase: Contrast Magnetic Resonance Imaging and Its Comparison with Echocardiographic Findings Evaluation of Coarctation of Aorta

Background: Coarctation of aorta (CoA) occurs when a small section of the aorta narrows in the luminal. CoA is one of the most popular congenital CL (cardiac lesions), and it is responsible for five to ten percent of all instances of congenital HD (heart disease). CoA can result in a variety of complications. Aims & Objectives: This research was undertaken to determine the occurrence of related CL and valvular disorders in patients with CoA. Materials and Methods: This research was carried out in the Department of Radiodiagnosis and Imaging (DORAI), Sher-i-Kashmir Institute of Medical Sciences (SKIMS) Tertiary Care Hospital, Srinagar, JK, India over a period of 2 years on patients referred from the Department of Cardiology. The patients who had been detected with CoA were given a PC-MRI to check their blood flow, and the comparison was made to the Echocardiographic study results. Results: Spin-echo (S-E) images of the level of the aortic arch (AA) as well as aortic isthmus (AI) showed narrowing in nineteen situations, according to the researchers. In eleven of the twenty situations, there was a significant amount of collateral circulation (CC). CC was significant in six out of eleven situations of serious stenosis