The Cosmic Ray ^3He/^4He Ratio from 200 MeV per Nucleon^(-1) to 3.7 GeV per Nucleon^(-1)

The abundances of cosmic-ray helium isotopes between 0.2 and 3.7 GeV nucleon^(-1) were measured by the Isotope Matter Antimatter Experiment (IMAX) during a flight from Lynn Lake, Manitoba, Canada on 1992 July 16-17. The IMAX balloon-borne magnetic spectrometer realized a direct measurement of the charge, the velocity, and the rigidity of cosmic rays using plastic scintillators, a high-resolution time-of-flight system, and two silica-aerogel Cerenkov counters in conjunction with a drift chamber/multiwire proportional chamber tracking system. About 75,000 helium isotopes are identified by their mass using the velocity versus magnetic rigidity technique. The measured ^3He/^4He ratios are corrected to the top of the atmosphere, and a comparison with previous data is given. The observed isotopic composition is found to be generally consistent with the predictions of a standard leaky box model of cosmic-ray transport in the Galaxy

Comparing etoricoxib and celecoxib for preemptive analgesia for acute postoperative pain in patients undergoing arthroscopic anterior cruciate ligament reconstruction: a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>The efficacy of selective cox-2 inhibitors in postoperative pain reduction were usually compared with conventional non-selective conventional NSAIDs or other types of medicine. Previous studies also used selective cox-2 inhibitors as single postoperative dose, in continued mode, or in combination with other modalities. The purpose of this study was to compare analgesic efficacy of single preoperative administration of etoricoxib versus celecoxib for post-operative pain relief after arthroscopic anterior cruciate ligament reconstruction.</p> <p>Methods</p> <p>One hundred and two patients diagnosed as anterior cruciate ligament injury were randomized into 3 groups using opaque envelope. Both patients and surgeon were blinded to the allocation. All of the patients were operated by one orthopaedic surgeon under regional anesthesia. Each group was given either etoricoxib 120 mg., celecoxib 400 mg., or placebo 1 hour prior to operative incision. Post-operative pain intensity, time to first dose of analgesic requirement and numbers of analgesic used for pain control and adverse events were recorded periodically to 48 hours after surgery. We analyzed the data according to intention to treat principle.</p> <p>Results</p> <p>Among 102 patients, 35 were in etoricoxib, 35 in celecoxib and 32 in placebo group. The mean age of the patients was 30 years and most of the injury came from sports injury. There were no significant differences in all demographic characteristics among groups. The etoricoxib group had significantly less pain intensity than the other two groups at recovery room and up to 8 hours period but no significance difference in all other evaluation point, while celecoxib showed no significantly difference from placebo at any time points. The time to first dose of analgesic medication, amount of analgesic used, patient's satisfaction with pain control and incidence of adverse events were also no significantly difference among three groups.</p> <p>Conclusions</p> <p>Etoricoxib is more effective than celecoxib and placebo for using as preemptive analgesia for acute postoperative pain control in patients underwent arthroscopic anterior cruciate ligament reconstruction.</p> <p>Trial registration number</p> <p>NCT01017380</p

The Cosmic Ray ^3He/^4He Ratio from 200 MeV/nucleon^(-1) to 3.7 GeV/nucleon^(-1)

The abundances of cosmic-ray helium isotopes between 0.2 and 3.7 GeV nucleon^(-1) were measured by the Isotope Matter Antimatter Experiment (IMAX) during a flight from Lynn Lake, Manitoba, Canada on 1992 July 16-17. The IMAX balloon-borne magnetic spectrometer realized a direct measurement of the charge, the velocity, and the rigidity of cosmic rays using plastic scintillators, a high-resolution time-of-flight system, and two silica-aerogel Cerenkov counters in conjunction with a drift chamber/multiwire proportional chamber tracking system. About 75,000 helium isotopes are identified by their mass using the velocity versus magnetic rigidity technique. The measured ^3He/^4He ratios are corrected to the top of the atmosphere, and a comparison with previous data is given. The observed isotopic composition is found to be generally consistent with the predictions of a standard leaky box model of cosmic-ray transport in the Galaxy

The Predatory Ecology of Deinonychus and the Origin of Flapping in Birds

Most non-avian theropod dinosaurs are characterized by fearsome serrated teeth and sharp recurved claws. Interpretation of theropod predatory ecology is typically based on functional morphological analysis of these and other physical features. The notorious hypertrophied ‘killing claw’ on pedal digit (D) II of the maniraptoran theropod Deinonychus (Paraves: Dromaeosauridae) is hypothesized to have been a predatory adaptation for slashing or climbing, leading to the suggestion that Deinonychus and other dromaeosaurids were cursorial predators specialized for actively attacking and killing prey several times larger than themselves. However, this hypothesis is problematic as extant animals that possess similarly hypertrophied claws do not use them to slash or climb up prey. Here we offer an alternative interpretation: that the hypertrophied D-II claw of dromaeosaurids was functionally analogous to the enlarged talon also found on D-II of extant Accipitridae (hawks and eagles; one family of the birds commonly known as “raptors”). Here, the talon is used to maintain grip on prey of subequal body size to the predator, while the victim is pinned down by the body weight of the raptor and dismembered by the beak. The foot of Deinonychus exhibits morphology consistent with a grasping function, supportive of the prey immobilisation behavior model. Opposite morphological trends within Deinonychosauria (Dromaeosauridae + Troodontidae) are indicative of ecological separation. Placed in context of avian evolution, the grasping foot of Deinonychus and other terrestrial predatory paravians is hypothesized to have been an exaptation for the grasping foot of arboreal perching birds. Here we also describe “stability flapping”, a novel behaviour executed for positioning and stability during the initial stages of prey immobilisation, which may have been pivotal to the evolution of the flapping stroke. These findings overhaul our perception of predatory dinosaurs and highlight the role of exaptation in the evolution of novel structures and behaviours

Song plasticity over time and vocal learning in clay-colored thrushes

Songbirds have been traditionally classified into close-ended or open-ended learning species according to the length of the sensitive period during which birds are able to memorize new vocalizations. Closed-ended learners are generally not capable of changing their song after the first year of life, while open-ended learners show song plasticity as adults. A few Turdus species have been sug- gested to be open-ended learners, but no long-term study has been conducted to investigate their song plasticity over time. We analyzed the songs of clay-colored thrushes, T. grayi, over four successive breeding seasons to assess song plasticity in their syllable repertoires within and between breeding seasons. A total of 16,262 syllables were classi- fied through visual inspection of spectrograms and multi- dimensional scaling analysis based on spectrogram correlations. On average, 563 ± 153 (SD) syllables per male per breeding season were analyzed. Male repertoire size was 9–20 syllable types. Males were capable of modifying their syllable repertoire between the initial and final periods of the breeding season. Song plasticity within breeding seasons may be associated with imitation between neighboring males, suggesting song learning in males that were C2 years old. This short-term plasticity is not enough, however, to explain the high proportion of change (mean = 65 % syllable types) in repertoire composition between breeding seasons in adult males. Song plasticity resulting from annual changes in repertoire composition could be explained by open-ended learning, but another mechanism, extended memory and re-expression, could also explain long-term plasticity. Experimental studies controlling the acoustic environment are needed to determine which mechanism is responsible for such a high level of song plasticity.UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologí

A slicing method for semantics-based change-merging of software prototypes

This report was presented as a paper at the Computers in Engineering Symposium in Houston, TX, on 30 January 1995.This report outlines a formal method for merging changes in independently developed versions of software prototypes. A useful semantics-based method, which is guaranteed to detect all conflicts, is outlined. Prototype slicing is used to determine the affected parts of each variation and the preserved part of the base in both variations. The affected parts are then combined with the preserved part to complete the merge. Our slicing theorem guarantees that this method produces a prototype that correctly exhibits the significant behavior of each of the input versions, provided the changes do not conflict. Correctness is achieved by comparing the slices of the variation and the merged program with respect to the affected parts of each variation. If the slices are the same, then the result is correct, otherwise a diagnostic message results. Preliminary testing shows that this tool will enhance the ability of the prototype developer to deliver a prototype more quickly by allowing more concurrency in the development effort

Comparative analysis of European residency programs: benchmarking and harmonizing ophthalmology training in Europe.

This study aims to benchmark the training programs of European ophthalmology residents. An online survey, aimed at European ophthalmology residents in training and those within two years of completion, was sent through the national representatives of the European Society of Ophthalmology, Young Ophthalmologists section (SOE-YO). The study involved 214 subjects representing 36 of the 44 European countries offering ophthalmology training programs. Among the surveyed, 74.8% of participants had an official national curriculum; 55.8% had a national specialty examination to accredit their training as ophthalmologists. 45.8% were satisfied or very satisfied with the clinical skills acquired, while 42.1% were completely dissatisfied with the surgical skills achieved. Considering the 4th year residents (mean duration of the residency), many of them did not perform phacoemulsification surgery (34%), pterygium excision (46.9%), or repair of eyelid laceration (31.3%). There is great heterogeneity in the competencies achieved by residents in training according to their country of origin, especially in terms of surgical competences