Variation in the Biomolecular Interactions of Nickel(Ii) Hydrazone Complexes Upon Tuning the Hydrazide Fragment

Three new bivalent nickel hydrazone complexes have been synthesised from the reactions of [NiCl2(PPh3)(2)] with H2L {L = dianion of the hydrazones derived from the condensation of o-hydroxynaphthaldehyde with furoic acid hydrazide (H2L1) (1)/thiophene-2-acid hydrazide (H2L2) (2)/isonicotinic acid hydrazide (H2L3) (3)} and formulated as [Ni(L-1)(PPh3)] (4), [Ni(L-2)(PPh3)] (5) and [Ni(L-3)(PPh3)] (6). Structural characterization of these compounds 4-6 were accomplished by using various physico-chemical techniques. Single crystal X-ray diffraction data of complexes 4 and 5 proved their distorted square planar geometry. In order to ascertain the potential of the above synthesised compounds towards biomolecular interactions, additional experiments involving interaction with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) were carried out. All the ligands and corresponding nickel(II) chelates have been screened for their scavenging effect towards O-2(-), OH and NO radicals. The efficiency of complexes 4-6 to arrest the growth of HeLa, HepG-2 and A431 tumour cell lines has been studied along with the cell viability test against the non-cancerous NIH 3T3 cells under in vitro conditions.University Grants Commission, New Delhi under the UGC-SAP-DRSRobert A. Welch Foundation F-0003Chemistr

Analysis of Antioxidant Enzyme activity in various genotypes of Helianthus annuus L. (Sunflower) under varied irrigation regimes

In this investigation, a pot culture experiment was conducted to estimate the effect of drought stress of Helianthus annuus L. (Sunflower). Sunflower is one of the most important oil crop and due to its high content of unsaturated fatty acids, a lack of cholesterol and the oil benefits from a desirable quality. Plant growth and productivity is adversely affected by nature’s wrath in the form of various biotic and abiotic stress factors. Water deficit is one of the major abiotic stresses, which   adversely affects crop growth and yield. The present study was aimed to understand the effects of drought stress on antioxidant enzymes like peroxidase, superoxide dismutase, catalase and ascorbate peroxidase activity on five different cultivars (SH 3322, A-110, K-618, SH 416, and S-275) of sunflower. All the sunflower cultivars showed reduced growth and altered enzymes activities under drought conditions. The antioxidant enzymes activities were increased under drought stress in all parts of the sunflower cultivars. The maximum activity was observed in K-618 and the minimum in S-275 cultivar. Among the five cultivars studied, K-618 showed better tolerance capacity in pot culture conditions under drought stress when compared to other cultivars studied.    Â

Drought stress induced modification on growth and Pigments composition in different genotypes of Helianthus annuus L.

In this investigation, a pot culture experiment was conducted to estimate the ameliorating effect of drought stress Induced modification on various growth and Pigments composition in different genotypes of Helianthus annuus L. (Sunflower). Economically important oil seed crop sunflower five cultivars viz., Asgrow SH 3322 (A-SH 3322), Agsun 110 (A-110), Kaveri 618 (K-618), SH 416, and Sunbred 275 (S-275) were selected for drought analysis. Plant growth and productivity is adversely affected by nature’s wrath in the form of various biotic and abiotic stress factors. Water deficit is one of the major abiotic stresses, which   adversely affects crop growth and yield. 3, 4 and 5 DID was selected for the drought stress treatments. Drought stress causes considerable decreases in growth and pigments content of sunflower. Among the cultivar K-618 was less affected by the drought and to it had increased root length and near normal vegetative and shoot growth during stress and at stress recovery. The growth parameters and pigment total chlorophyll and carotenoid content decreased under drought stress in all the sunflower cultivars. Among the cultivars the S-275 cultivar was severely affected when compared to other cultivars

rac-6-Eth­oxy-3,3a,4,9b-tetra­hydro-1,3-diphenyl-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile

The title compound, C25H22N2O3, with three stereogenic centres, crystallizes in a centrosymmetric space group as a racemate. The pyran ring adopts a sofa conformation and the five-membered isoxazole ring exhibits an envelope conformation. The dihedral angle between the benzene ring and the mean plane through the near coplanar atoms of the pyran ring is 10.54 (9)°. In the crystal, no significant intermolecular interactions are observed

(E)-3-Phenyl-2-(1-tosyl-1H-indol-3-ylcarbon­yl)acrylonitrile

In the title compound, C25H18N2O3S, the indole moiety is planar and makes a dihedral angle of 89.95 (09)° with the phenyl ring of the sulfonyl substituent. The mol­ecular conformation features a weak C—H⋯N short contact and the crystal packing reveals a weak C—H⋯O hydrogen bond

Utišani gga-miR-142-3p u pilećem embriju: ekspresija profila XPO1.

Differential expression of gga-miR-142-3p microRNA of haemopoeitic origin during immune organ development and functional stages in chicken embryos creates new opportunities for understanding its pivotal role during embryonic developmental stages. To decipher the role of gga-miR-142-3p in-ovo knockdown was carried out with LNA modified anti-miR-gga-miR-142-3p via intravenous route at developmental and functional stages of the immune organs and other organs. Bioinformatic analysis of the genes targeted by gga-miRNA-142-3p revealed that the predicted gene XPO1 conserved binding sites at 3’UTR. The target gene XPO1 was evaluated as the validated target of gga-miR-142-3p by employing qPCR SYBR green based technology, which was evidenced by its increased expression in the tissues of gga-miR-142-3p knockdown chicken embryos. Histopathological alterations in the immune organs and visceral organs indicated that the systemic knockdown of gga-miR-124-3p led to over expression of the XPO1 gene during the embryonic stages, and changed the environment of the immune organs related to structural integrity, immune response, signal transduction and migration of B and T cells during the embryonic developmental stage in the chicken embryos. The results clearly indicated that these changes could alter the postnatal development and functions of these immune organs, and may lead to development of immuno-compromised chickens.Različita ekspresija gga-miR-142-3p mikroRNA hemopoetskog podrijetla daje nove mogućnosti razumijevanja njezine ključne uloge u embrionalnom razvoju limfnih organa i funkcionalnih zbivanja u pilećem zametku. Za otkrivanje uloge gga-miR-142-3p in ovo provedeno je utišavanje zaključanom nukleinskom kiselinom što preko anti-miR-gga-miR-142-3p preinačuje razvojne i funkcionalne sposobnosti limfnih i drugih organa. Bioinformatička analiza ciljnih gena za gga-miRNA-142-3p otkriva da gen XPO1 ima konzervirana mjesta vezanja na 3’UTR. Gen XPO1 bio je potvrđen kao cilj za gga-miR-142-3p uporabom tehnologije temeljene na qPCR SYBR zelenilu, što je bilo dokazano njegovom povećanom ekspresijom u tkivima pilećih zametaka s utišanim gga-miR-142-3p. Patohistološke promjene u imunosnim i unutarnjim organima pokazuju da sustavno utišavanje gga-miR-124-3p vodi do prevelike ekspresije gena XPO1 tijekom embrionalnog razvoja. To mijenja zadaću imunosnih organa s obzirom na strukturni integritet, imunosni odgovor, prijenos poruka te migraciju B i T limfocita tijekom razvoja pilećih zametaka. Rezultati jasno naznačuju da te promjene mogu preinačiti postnatalni razvoj i funkcije imunosnih organa te mogu dovesti do razvoja imunološki oslabljenih pilića

2-Iodo-3-(4-meth­oxy­anilino)-5,5-dimethyl­cyclo­hex-2-en-1-one

The cyclo­hexene ring in the title compound, C15H18INO2, adopts a sofa conformation. The dihedral angle between the cyclo­hexene (through all ring atoms) and benzene rings is 63.3 (1)°. The mol­ecular conformation features an N—H⋯I short contact and the crystal packing features C—H⋯O hydrogen bonds

Smart Wearable Gadget for Miners Using IOT

Safety is the most important part of any kind of assiduity is safety. In extreme circumstances, safety-related negligence could result in the destruction of expensive clothing or the loss of human life. Every min-ing diligence adhere to a few basic preventative measures in order to avoid any generally unwelcome wonders. The most important component at this time is communication in order to continuously monitor various pa-rameters and take the appropriate actions as a result to avoid any risks linked with the product or the management of mortal funds. A stable and wide-range effective communication system between personnel in the mine and the control centre must be built in order to increase safety in un-derground mines. The cable communication network technology is inef-fective within underground mines. Here we can tackle the matter of acci-dents which end with death of several people per annum. It is discovered that the speed of fatality within the coal pit industry is almost six times the speed for all private industries. And most of those accidents are because of toxic gases, fires, and a lack of rescue systems. By implementing mine surveillance gadgets, which may be used within the mine and detect the number of various gases, fall, emergency detection and report to them. This article focuses on the design and analysis of the smart wearable gadget for miners in the mining industry using IoT

Topology and Ground State Control In Open-Shell Donor-Acceptor Conjugated Polymers

Donor-acceptor (DA) conjugated polymers (CPs) with narrow bandgaps and open-shell (diradical) character represent an emerging class of materials whose rich behavior emanates from their collective electronic properties and diminished electron pairing. However, the structural and electronic heterogeneities that define these materials complicate bandgap control at low energies and connections linking topology, exchange interactions, and (opto)electronic functionality remain nascent. To address these challenges, we demonstrate structurally rigid and strongly π-conjugated copolymers comprised of a solubilizing thiadiazoloquinoxaline acceptor and cyclopenta[2,1-b:3,4-b′]dithiophene or dithieno[3,2-b:2′,3′-d]thiophene donors. Atom-specific substitution modulates local aromatic character within the donor resulting in dramatic differences in structural, physicochemical, electronic, and magnetic properties of the polymers. These long-range π-mediated interactions facilitate control between low-spin aromatic and high-spin quinoidal forms. This work provides a strategy to understand the evolution of the electronic structure within DA CPs, control the ground state spin multiplicity, tune spin-spin interactions, and articulate the emergence of their novel properties