1,935 research outputs found
Phosphorene-AsP Heterostructure as a Potential Excitonic Solar Cell Material - A First Principles Study
Solar energy conversion to produce electricity using photovoltaics is an
emerging area in alternative energy research. Herein, we report on the basis of
density functional calculations, phosphorene/AsP heterostructure could be a
promising material for excitonic solar cells (XSCs). Our HSE06 functional
calculations show that the band gap of both phosphorene and AsP fall exactly
into the optimum value range according to XSCs requirement. The calculated
effective mass of electrons and holes show anisotropic in nature with effective
masses along -X direction is lower than the -Y direction
and hence the charge transport will be faster along -X direction. The
wide energy range of light absorption confirms the potential use of these
materials for solar cell applications. Interestingly, phosphorene and AsP
monolayer forms a type-II band alignment which will enhance the separation of
photogenerated charge carriers and hence the recombination rate will be lower
which can further improve its photo-conversion efficiency if one use it in
XSCs
The Gene Ontology: enhancements for 2011
The Gene Ontology (GO) (http://www.geneontology.org) is a community bioinformatics resource that represents gene product function through the use of structured, controlled vocabularies. The number of GO annotations of gene products has increased due to curation efforts among GO Consortium (GOC) groups, including focused literature-based annotation and ortholog-based functional inference. The GO ontologies continue to expand and improve as a result of targeted ontology development, including the introduction of computable logical definitions and development of new tools for the streamlined addition of terms to the ontology. The GOC continues to support its user community through the use of e-mail lists, social media and web-based resources
APRIL:TACI axis is dispensable for the immune response to rabies vaccination.
There is significant need to develop a single-dose rabies vaccine to replace the current multi-dose rabies vaccine regimen and eliminate the requirement for rabies immune globulin in post-exposure settings. To accomplish this goal, rabies virus (RABV)-based vaccines must rapidly activate B cells to secrete antibodies which neutralize pathogenic RABV before it enters the CNS. Increased understanding of how B cells effectively respond to RABV-based vaccines may improve efforts to simplify post-exposure prophylaxis (PEP) regimens. Several studies have successfully employed the TNF family cytokine a proliferation-inducing ligand (APRIL) as a vaccine adjuvant. APRIL binds to the receptors TACI and B cell maturation antigen (BCMA)-expressed by B cells in various stages of maturation-with high affinity. We discovered that RABV-infected primary murine B cells upregulate APRIL ex vivo. Cytokines present at the time of antigen exposure affect the outcome of vaccination by influencing T and B cell activation and GC formation. Therefore, we hypothesized that the presence of APRIL at the time of RABV-based vaccine antigen exposure would support the generation of protective antibodies against RABV glycoprotein (G). In an effort to improve the response to RABV vaccination, we constructed and characterized a live recombinant RABV-based vaccine vector which expresses murine APRIL (rRABV-APRIL). Immunogenicity testing in mice demonstrated that expressing APRIL from the RABV genome does not impact the primary antibody response against RABV G compared to RABV alone. In order to evaluate the necessity of APRIL for the response to rabies vaccination, we compared the responses of APRIL-deficient and wild-type mice to immunization with rRABV. APRIL deficiency does not affect the primary antibody response to vaccination. Furthermore, APRIL expression by the vaccine did not improve the generation of long-lived antibody-secreting plasma cells (PCs) as serum antibody levels were equivalent in response to rRABV-APRIL and the vector eight weeks after immunization. Moreover, APRIL is dispensable for the long-lived antibody-secreting PC response to rRABV vaccination as anti-RABV G IgG levels were similar in APRIL-deficient and wild-type mice six months after vaccination. Mice lacking the APRIL receptor TACI demonstrated primary anti-RABV G antibody responses similar to wild-type mice following immunization with the vaccine vector indicating that this response is independent of TACI-mediated signals. Collectively, our findings demonstrate that APRIL and associated TACI signaling is dispensable for the immune response to RABV-based vaccination
Building a resilient education system for continued and sustainable student engagement #AccountingMondays
Cystine peptides: the intramolecular antiparallel β-sheet conformation of a 20-membered cyclic peptide disulfide
A 20-membered cyclic peptide disulfide has been synthesized as a conformational model for disulfide loops of limited ring size. 1H-nmr studies at 270 MHz establish the presence of three intramolecular hydrogen bonds involving the Leu, Val, and methylamide NH groups in CDCl3. Evidence for peptide aggregation in CDCl3 is also presented. A structural transition involving loosening of the hydrogen bond formed by the Val NH group is observed upon the measured addition of (CD3)2SO to CDCl3. Hydrogen-bonding studies, together with unusually low field positions of the Cys(1) and Cys(6) CαH resonances and high JHNCαH values provide support for an intramolecular antiparallel β-sheet conformation, facilitated by a chain reversal at the Aib-Ala segment. Extensive nuclear Overhauser effect studies provide compelling evidence for the proposed conformation and also establish a type I′ β -turn at the Aib-Ala residues, the site of the chain reversal
First report on observation of abnormal creep in a Zr-2.5wt.%Nb alloy at low stresses
Low-stress creep behaviour of a two-phase Zr-2.5%Nb alloy, differently heat treated, has been investigated using helical test specimens. The phase diagram of the α (hcp) + β (bcc) alloy is characterized by the monotectoid reaction at 893 ± 10 K: β1 → (α + β2) where β1 (Zr-20Nb) and β2 (Zr-80Nb) have widely differing compositions. At the creep testing temperature, 818 K, which is close to but below the monotectoid temperature, the creep rate for samples with the equilibrium α + β2 structure has been found to be considerably higher, over an order of magnitude, than that in samples with the metastable α + β1 structure. Microstructural changes accompanying the markedly enhanced creep rate for the α + β2 structure at stresses as low as 1-4 MPa have been explained in terms of the relative stability of the β1 and the β2 phases during the creep process. An attempt has been made to elicit the likely mechanism underlying the observed enhancement of creep rate and the changes in morphology, composition and volume fraction of the β phase
The Vortex Phase Qubit: Generating Arbitrary, Counter-Rotating, Coherent Superpositions in Bose-Einstein Condensates via Optical Angular Momentum Beams
We propose a scheme for generation of arbitrary coherent superposition of
vortex states in Bose-Einstein condensates (BEC) using the orbital angular
momentum (OAM) states of light. We devise a scheme to generate coherent
superpositions of two counter-rotating OAM states of light using known
experimental techniques. We show that a specially designed Raman scheme allows
transfer of the optical vortex superposition state onto an initially
non-rotating BEC. This creates an arbitrary and coherent superposition of a
vortex and anti-vortex pair in the BEC. The ideas presented here could be
extended to generate entangled vortex states, design memories for the OAM
states of light, and perform other quantum information tasks. Applications to
inertial sensing are also discussed.Comment: 4 pages, 4 figures, Revtex4, to be submitted to Phys. Rev. Let
Kinetics of Heterogeneous Reaction between o-Toluidine Nitrate & Red Fuming Nitric Acid
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Comparison of feeding methods in neonates - A retrospective cohort study from India
Background: Preterm babies who are unable to breastfeed but are able to swallow are commenced on cup or paladai or bottle as alternative feeding methods. Although the World Health Organization recommends the use of cup owing to reduced infection risk, many neonatal units use the bottle for feeding. Objectives: The aim was to compare the two groups with regard to time taken to commence oral feeds, breastfeeds, achieve full oral feeds, complications, gestational age at discharge, discharge weight, and infant formula use at discharge. Material and Methods: This retrospective observational study was performed to compare two cohorts ofpreterm babies who were fed either by bottle or paladai (small feeding cup with a long spout traditionally used in India) during their transition from tube to breastfeeding. Results: During the study period, there were 68 babies in Center 1 where paladai was used and 71 in Center 2 where bottle was used. The gestational age at which oral feeding was commenced, full oral feeds, gestational age at discharge, and discharge weight were similar in both the groups. Breastfeeding was commenced significantly earlier in the bottle-fed group (p<0.05). The use of infant formula was also significantly more in this group. One baby aspirated in the paladaigroup. Conclusion: With adequate training and attention to hygiene, paladai or feeding bottles could be equally safe methods of feeding in hospitalized preterm neonates
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