A multi-level approach to flood frequency regionalisation

A multi-level approach to flood frequency regionalisation is given. Based on observed flood data, it combines physical and statistical criteria to cluster homogeneous groups in a geographical area. Seasonality analysis helps identify catchments with a common flood generation mechanism. Scale invariance of annual maximum flood, as parameterised by basin area, is used to check the regional homogeneity of flood peaks. Homogeneity tests are used to assess the statistical robustness of the regions. The approach is based on the appropriate use of the index flood method (Dalrymple, 1960) in regions with complex climate and topography controls. An application to north-western Italy is presented.</p> <p style='line-height: 20px;'><b>Keywords:</b> homogeneity, multi-level approach, regionalisation, seasonality, scale invariance, similarity, test

Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo

In the sea urchin embryo, the large micromeres and their progeny function as a critical signaling center and execute a complex morphogenetic program. We have identified a new and essential component of the gene network that controls large micromere specification, the homeodomain protein Alx1. Alx1 is expressed exclusively by cells of the large micromere lineage beginning in the first interphase after the large micromeres are born. Morpholino studies demonstrate that Alx1 is essential at an early stage of specification and controls downstream genes required for epithelial-mesenchymal transition and biomineralization. Expression of Alx1 is cell autonomous and regulated maternally through ß-catenin and its downstream effector, Pmar1. Alx1 expression can be activated in other cell lineages at much later stages of development, however, through a regulative pathway of skeletogenesis that is responsive to cell signaling. The Alx1 protein is highly conserved among euechinoid sea urchins and is closely related to the Cart1/Alx3/Alx4 family of vertebrate homeodomain proteins. In vertebrates, these proteins regulate the formation of skeletal elements of the limbs, face and neck. Our findings suggest that the ancestral deuterostome had a population of biomineral-forming mesenchyme cells that expressed an Alx1-like protein

A multi-level approach to flood frequency regionalisation

International audienceA multi-level approach to flood frequency regionalisation is given. Based on observed flood data, it combines physical and statistical criteria to cluster homogeneous groups in a geographical area. Seasonality analysis helps identify catchments with a common flood generation mechanism. Scale invariance of annual maximum flood, as parameterised by basin area, is used to check the regional homogeneity of flood peaks. Homogeneity tests are used to assess the statistical robustness of the regions. The approach is based on the appropriate use of the index flood method (Dalrymple, 1960) in regions with complex climate and topography controls. An application to north-western Italy is presented. Keywords: homogeneity, multi-level approach, regionalisation, seasonality, scale invariance, similarity, test

Review of recent advances in index flood estimation

International audienceIndex flood estimation for regional flood frequency analysis needs to be based on the information available. The most appropriate method depends on the specific application and its choice requires a problem-oriented analysis. This paper presents a simple theoretical framework to deal with index flood estimation for a specific river site. The methodological approaches available for the purpose are reviewed. For each, the information required is specified and the reliability of the estimate, particularly desirable in risk analysis and management, is discussed. Where flood observations are lacking, indirect estimation must be undertaken using scenarios including those commonly met in hydrological practice; generally, these depend on the amount and type of information available. For each scenario, the methodologies are outlined, in order of the expected degree of complexity. After a guided analysis, an investigator can adopt the method providing the best tradeoff between effort in collecting and handling data and the resultant reliability which can be expected. Keywords: direct and indirect methods, index flood estimation, reliability, scenarios

PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism.

We analyzed the PINK1 gene in 58 patients with early-onset Parkinsonism and detected the homozygous mutation W437X in 1 patient. The clinical phenotype was characterized by early onset (22 years of age), good re- sponse to levodopa, early fluctuations and dyskinesias, and psychiatric symptoms. The mother, heterozygote for W437X mutation, was affected by Parkinson’s disease and 3 further relatives were reported affected, according to an autosomal dominant transmission

Visual Field Loss Morphology in High- and Normal-Tension Glaucoma

Purpose. To determine whether the patterns of visual field damage between high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) are equivalent. Methods. In this retrospective cross-sectional study, fifty-one NTG and 57 HTG patients were recruited. For each recruited patient only the left eye was chosen. Glaucomatous patients had abnormal visual fields and/or glaucomatous changes at the optic nerve head. They were classified as HTG or NTG on the basis of intraocular pressure (IOP) measurements. Patients' visual fields were analyzed by using Humphrey Field Analyzer (HFA), program 30-2, full threshold. The visual field sensitivity values and the pattern deviation map values of the 72 tested points were considered. Then a pointwise analysis and an area analysis, based on the Glaucoma Hemifield test criteria, were performed, and a comparison between the two subgroups was made by Student's t test. Results. Between NTG and HTG, no significant difference was found pointwise for almost all the visual field points, except for two locations. One was under the blind spot, and the other was in the inferior hemifield around the twenty-degree position. When area analysis was considered, three areas showed a significantly different sensitivity between HTG and NTG. Conclusions. These data suggested that there was no relevant difference in the pointwise analysis between NTG and HTG; however, when visual field areas were compared, no difference in paracentral areas was found between NTG and HTG, but superior nasal step and inferior and superior scotomata showed to be deeper in HTG than in NTG

A correlational analysis of the relationships among intolerance of uncertainty, anxiety sensitivity, subjective sleep quality, and insomnia symptoms

In this study, we used structural equation modeling to investigate the interplay among Intolerance of Uncertainty (IU), Anxiety Sensitivity (AS), and sleep problems. Three hundred undergraduate students completed the Intolerance of Uncertainty Scale, the Intolerance of Uncertainty Inventory, the Anxiety Sensitivity Index, the Beck Depression Inventory, the State-Trait Anxiety Inventory, the Pittsburgh Sleep Quality Index and the Insomnia Severity Index. 68% and 40% of the students reported poor sleep quality or sub-threshold insomnia problems, respectively. Depression and anxiety levels were above the cut-off for about one-fourth of the participants. Structural equation modeling revealed that IU was strongly associated with AS, in turn influencing both insomnia severity and sleep quality via depression and anxiety. Significant indirect effects revealed that an anxious pathway was more strongly associated with insomnia severity, while a depression pathway was more relevant for worsening the quality of sleep. We discussed the results in the frameworks of cognitive models of insomnia. Viewing AS and IU as antecedents of sleep problems and assigning to AS a pivotal role, our study suggested indications for clinical interventions on a population at risk for sleep disorders

Capgras-like syndrome in a patient with an acute urinary tract infection.

Delusional misidentification syndromes are a group of delusional phenomena in which patients misidentify familiar persons, objects, or themselves, believing that they have been replaced or transformed. In 25%-40% of cases, misidentification syndromes have been reported in association with organic illness. We report an acute episode of Capgras-like delusion lasting 8 days, focused on the idea that people were robots with human bodies, in association with an acute urinary infection. To our knowledge, this is the first case report associating urinary tract infection with Capgras-like syndrome. Awareness of the prevalence of delusional misidentification syndromes associated with acute medical illness should promote diligence on the part of clinicians in recognizing this disorder

Dynamical and photometric imprints of feedback processes on the early evolution of E/S0 galaxies

We show that the observed Velocity Dispersion Function of E/S0 galaxies matches strikingly well the distribution function of virial velocities of massive halos virializing at z > 1.5, as predicted by the standard hierarchical clustering scenario in a \LambdaCDM cosmology, for a constant ratio sigma/V_vir = 0.55 \pm 0.05, close to the value expected at virialization if it typically occurred at z > 3. This strongly suggests that dissipative processes and later merging events had little impact on the matter density profile. Adopting the above sigma/V_vir ratio, the observed relationships between photometric and dynamical properties which define the fundamental plane of elliptical galaxies, such as the luminosity-sigma (Faber-Jackson) and the luminosity-effective radius relations, as well as the M_BH-sigma relation, are nicely reproduced. Their shapes turn out to be determined by the mutual feedback of star-formation (and supernova explosions)and nuclear activity, along the lines discussed by Granato et al. (2004). To our knowledge, this is the first semi-analytic model for which simultaneous fits of the fundamental plane relations and of the epoch-dependent luminosity function of spheroidal galaxies have been presented.Comment: 14 pages, 6 figures, submitted to Ap

Clustering of concurrent flood risks via Hazard Scenarios

The study of multiple effects of a number of variables, and the assessment of the corresponding environmental risks, may require the adoption of suitable multivariate models when the variables at play are dependent, as it often happens in environmental studies. In this work, the flood risks in a given region are investigated, in order to identify specific spatial sub-regions (clusters) where the floods show a similar behavior with respect to suitable multivariate) criteria. The reason of the work is three-fold, and the outcomes have deep implications in the hydrological practice: (i) such a regionalization (as it is called in hydrology) may provide useful indications for deciding which gauge stations have a similar (stochastic) behavior; (ii) the spatial clustering may represent a valuable tool for investigating ungauged basins present in a given ‘‘homogeneous’’ Region; (iii) the estimate of extreme design values may be improved by using all the observations collected in a cluster (instead of only single-station data). For this purpose, a Copulabased Agglomerative Hierarchical Clustering algorithm – a key tool in geosciences for the analysis of the dependence information – is proposed. The procedure is illustrated via a case study involving the Po river basin, the largest Italian one. A comparison with a previous attempt to cluster the gauge stations present in the same spatial region is also carried out. The sub-regions picked out by the clustering procedure outlined here agree with previous results obtained via heuristic hydrological and meteorological reasonings, and identify spatial areas characterized by similar flood regimes