Design and Validation of a Bifunctional Ligand Display System for Receptor Targeting

AbstractHere we developed a bacteriophage display particle designed to serve as a bifunctional entity that can target tumors while delivering an agent. We engineered a chimera phage vector containing a pIII-displayed αv integrins-targeting moiety and a pVIII-displayed streptavidin binding adaptor moiety. By using the chimeric phage particle, targeting of αv integrins on cells in culture and tumor-related blood vessels was shown through different applications, including luminescent quantum dots localization, surface plasmon resonance-based binding detection, and an in vivo tumor model. The strategy validated here will accelerate the discovery and characterization of receptor-ligand binding events in high throughput, and cell-specific delivery of diagnostics or therapeutics to organs of choice without the need for chemical conjugation

GP-SUM. Gaussian Processes Filtering of non-Gaussian Beliefs

This work studies the problem of stochastic dynamic filtering and state propagation with complex beliefs. The main contribution is GP-SUM, a filtering algorithm tailored to dynamic systems and observation models expressed as Gaussian Processes (GP), and to states represented as a weighted sum of Gaussians. The key attribute of GP-SUM is that it does not rely on linearizations of the dynamic or observation models, or on unimodal Gaussian approximations of the belief, hence enables tracking complex state distributions. The algorithm can be seen as a combination of a sampling-based filter with a probabilistic Bayes filter. On the one hand, GP-SUM operates by sampling the state distribution and propagating each sample through the dynamic system and observation models. On the other hand, it achieves effective sampling and accurate probabilistic propagation by relying on the GP form of the system, and the sum-of-Gaussian form of the belief. We show that GP-SUM outperforms several GP-Bayes and Particle Filters on a standard benchmark. We also demonstrate its use in a pushing task, predicting with experimental accuracy the naturally occurring non-Gaussian distributions.Comment: WAFR 2018, 16 pages, 7 figure

Color-octet mechanism and J/psi polarization at LEP

Polarized heavy quarkonium productions in $Z^0$ decays are considered. We find that polarizations of the produced quarkonia are independent of that of the parent Z^0 provided that one considers the energy distribution or the total production rate. Produced J/psi's via the color-octet and the color- singlet mechanisms are expected to be 19% and 29% longitudinally polarized, respectively. The energy dependence of eta_{1,8}(x)=\frac{dGamma_{1,8}^L}{dx} /\frac{dGamma_{1,8}}{d x} is very sensitive to the production mechanism, and therefore the measurement of \eta(x)_exp will be an independent probe of the color-octet mechanism.Comment: 15 pages, minor changes, version to be published in Phys. Rev.

J/\psi production through resolved photon processes at e+ e- colliders

We consider J/psi photoproduction in e+ e- as well as linear photon colliders. We find that the process is dominated by the resolved photon channel. Both the once-resolved and twice-resolved cross-sections are sensitive to (different combinations of) the colour octet matrix elements. Hence, this may be a good testing ground for colour octet contributions in NRQCD. On the other hand, the once-resolved J/psi production cross-section, particularly in a linear photon collider, is sensitive to the gluon content of the photon. Hence these cross-sections can be used to determine the parton distribution functions, especially the gluon distribution, in a photon, if the colour octet matrix elements are known.Comment: Added a figure on parametrisation dependence of photonic parton densities and some reference

Muon Anomalous g−2g -2 and Gauged Lμ−LτL_\mu - L_\tau Models

In this paper we study $Z'$ contribution to $g -2$ of the muon anomalous magnetic dipole moment in gauged $U(1)_{L_\mu - L_\tau}$ models. Here $L_i$ are the lepton numbers. We find that there are three classes of models which can produce a large value of $g-2$ to account for possible discrepancy between the experimental data and the Standard Model prediction. The three classes are: a) Models with an exact $U(1)_{L_\mu - L_\tau}$. In these models, $Z'$ is massless. The new gauge interaction coupling $e a/\cos\theta_W$ is constrained to be $0.8\times 10^{-3} < |a| < 2.24\times 10^{-3}$. b) Models with broken $U(1)_{L_\mu - L_\tau}$ and the breaking scale is not related to electroweak symmetry breaking scale. The $Z'$ gauge boson is massive. The allowed range of the coupling and the $Z'$ mass are constrained, but $Z'$ mass can be large; And c) The $U(1)_{L_\mu-L_\tau}$ is broken and the breaking scale is related to the electroweak scale. In this case the $Z'$ mass is constrained to be $\sim 1.2$ GeV. We find that there are interesting experimental signatures in $\mu^+\mu^-\to \mu^+\mu^-, \tau^+\tau^-$ in these models.Comment: 13 pages, 9 figure

Evidence for Colour-Octet Mechanism from CERN LEP2 gamma gamma -> J/psi + X Data

We present theoretical predictions for the transverse-momentum distribution of J/psi mesons promptly produced in gamma gamma collisions within the factorization formalism of nonrelativistic quantum chromodynamics, including the contributions from both direct and resolved photons, and we perform a conservative error analysis. The fraction of J/psi mesons from decays of bottom-flavoured hadrons is estimated to be negligibly small. New data taken by the DELPHI Collaboration at LEP2 nicely confirm these predictions, while they disfavour those obtained within the traditional colour-singlet model.Comment: 11 pages (Latex), 3 figures (Postscript); updated experimental data included, references added, accepted for publication in Phys. Rev. Let

Collective modes of asymmetric nuclear matter in Quantum HadroDynamics

We discuss a fully relativistic Landau Fermi liquid theory based on the Quantum Hadro-Dynamics ($QHD$) effective field picture of Nuclear Matter ({\it NM}). From the linearized kinetic equations we get the dispersion relations of the propagating collective modes. We focus our attention on the dynamical effects of the interplay between scalar and vector channel contributions. A beautiful ``mirror'' structure in the form of the dynamical response in the isoscalar/isovector degree of freedom is revealed, with a complete parallelism in the role respectively played by the compressibility and the symmetry energy. All that strongly supports the introduction of an explicit coupling to the scalar-isovector channel of the nucleon-nucleon interaction. In particular we study the influence of this coupling (to a $\delta$-meson-like effective field) on the collective response of asymmetric nuclear matter ($ANM$). Interesting contributions are found on the propagation of isovector-like modes at normal density and on an expected smooth transition to isoscalar-like oscillations at high baryon density. Important ``chemical'' effects on the neutron-proton structure of the mode are shown. For dilute $ANM$ we have the isospin distillation mechanism of the unstable isoscalar-like oscillations, while at high baryon density we predict an almost pure neutron wave structure of the propagating sounds.Comment: 18 pages (LATEX), 8 Postscript figures, uses "epsfig

J/ψ+c+cˉJ/\psi + c + \bar{c} Photoproduction in e+e−e^+ e^- Scattering

We investigate the $J/\psi$ + c + $\bar{c}$ photoproduction in $e^+ e^-$ collision at the LEP II energy. The physical motivations for this study are: 1) such next-to-leading order(NLO) process was not considered in previous investigations of $J/\psi$ photoproduction in $e^+ e^-$ interaction, and it is worthwhile to do so in order to make sound predictions for experimental comparison; 2) from recent Belle experiment results, the process with same final states at the $B$ factory has a theoretically yet unexplainable large fraction; hence it is interesting to see what may happen at other colliders; 3) the existing LEP data are marginal in observing such process, and at the planed Linear Colliders(LCs) this process can be measured with high accuracy; 4) it is necessary to take this process into consideration in the aim of elucidating the quarkonium production mechanism, especially in testing the universality of NRQCD nonperturbative matrix elements via $J/\psi$ photoproduction in electron-position collisions.Comment: 15 pages, 3 figure

The effect of transmucosal 0.2mg/kg Midazolam premedication on dental anxiety, anaesthetic induction and psychological morbidity in children undergoing general anaesthesia for tooth extraction

&lt;b&gt;Background:&lt;/b&gt; The project aims were to evaluate the benefit of transmucosal Midazolam 0.2mg/kg pre-medication on anxiety, induction behaviour and psychological morbidity in children undergoing general anaesthesia (GA) extractions. &lt;b&gt;Method:&lt;/b&gt; 179 children aged 5-10 years (mean 6.53 years) participated in this randomised, double blind, placebo controlled trial. Ninety children had Midazolam placed in the buccal pouch. Dental anxiety was recorded pre operatively and 48 hours later using a child reported MCDAS-FIS scale. Behaviour at anaesthetic induction was recorded and psychological morbidity was scored by the parent using the Rutter Scale pre-operatively and again one-week later. Subsequent dental attendance was recorded at one, three and six months after GA. &lt;b&gt;Results:&lt;/b&gt; Whilst levels of mental anxiety did not reduce overall, the most anxious patients demonstrated a reduction in anxiety after receiving midazolam premedicationmay (p=0.01). Neither induction behaviour nor psychological morbidity improved. Irrespective of group, parents reported less hyperactive (p= 0.002) and more prosocial behaviour (p=0.002) after the procedure:;, older children improved most (p=0.048), Post GA Dental attendance was poor and unrelated to after the procedure and unaffected by premedication. &lt;b&gt;Conclusion:&lt;/b&gt; 0.2mg/kg buccal Midazolam provided some evidence for reducing anxiety in the most dentally anxious patients. However, induction behaviour, psychological morbidity and subsequent dental attendance were not found to alter between the premedication groups

Towards Minimal S4 Lepton Flavor Model

We study lepton flavor models with the $S_4$ flavor symmetry. We construct simple models with smaller numbers of flavon fields and free parameters, such that we have predictions among lepton masses and mixing angles. The model with a $S_4$ triplet flavon is not realistic, but we can construct realistic models with two triplet flavons, or one triplet and one doublet flavons.Comment: 18 pages, 4 figures, references are adde