Time delay between photoemission from the 2p and 2s subshells of Neon

The R-Matrix incorporating Time (RMT) method is a new method for solving the time-dependent Schroedinger equation for multi-electron atomic systems exposed to intense short-pulse laser light. We have employed the RMT method to investigate the time delay in the photoemission of an electron liberated from a 2p orbital in a neon atom with respect to one released from a 2s orbital following absorption of an attosecond XUV pulse. Time delays due to XUV pulses in the range 76-105 eV are presented. For an XUV pulse at the experimentally relevant 105.2 eV, we calculate the time delay to be 10.2 +/- 1.3 attoseconds, somewhat larger than estimated by other theoretical calculations, but still a factor two smaller than experiment. We repeated the calculation for a photon energy of 89.8 eV with a larger basis set capable of modelling correlated-electron dynamics within the neon atom and the residual Ne(+) ion. A time delay of 14.5 +/- 1.5 attoseconds was observed, compared to a 16.7 +/- 1.5 attosecond result using a single-configuration representation of the residual Ne(+) ion.Comment: 4 pages, 3 figures, 1 tabl

Time-dependent restricted active space Configuration Interaction for the photoionization of many-electron atoms

We introduce the time-dependent restricted active space Configuration Interaction method to solve the time-dependent Schr\"odinger equation for many-electron atoms, and particularly apply it to the treatment of photoionization processes in atoms. The method is presented in a very general formulation and incorporates a wide range of commonly used approximation schemes, like the single-active electron approximation, time-dependent Configuration Interaction with single-excitations, or the time-dependent R-matrix method. We proof the applicability of the method by calculating the photoionization cross sections of Helium and Beryllium, as well as the X-ray--IR pump-probe ionization in BerylliumComment: 12 pages, 9 figure

Using differential reinforcement of high rates of behavior to improve work productivity : a replication and extension

Background: Due to deficits in adaptive and cognitive functioning, productivity may pose challenges for individuals with intellectual disability in the workplace.Method: Using a changing‐criterion embedded in a multiple baseline across partici‐pants design, we examined the effects of differential reinforcement of high rates of behaviour (DRH) on the rate of data entry (i.e., productivity) in four adults with intel‐lectual disability.Results: Although the DRH procedure increased the rate of correct data entry in all four participants, none of the participants achieved the criterion that we set with novice undergraduate students.Conclusions: Our results indicate that DRH is an effective intervention to increase rate of correct responding in individuals with intellectual disability, but that achiev‐ing the same productivity as workers without disability may not always be possible

Implementation of genomics in medical practice to deliver precision medicine for an Asian population

Whilst the underlying principles of precision medicine are comparable across the globe, genomic references, health practices, costs and discrimination policies differ in Asian settings compared to the reported initiatives involving European-derived populations. We have addressed these variables by developing an evolving reference base of genomic and phenotypic data and a framework to return medically significant variants to consenting research participants applicable for the Asian context. Targeting 10,000 participants, over 2000 Singaporeans, with no known pre-existing health conditions, have consented to an extensive clinical health screen, family health history collection, genome sequencing and ongoing follow-up. Genomic variants in a subset of genes associated with Mendelian disorders and drug responses are analysed using an in-house bioinformatics pipeline. A multidisciplinary team reviews the classification of variants and a research report is generated. Medically significant variants are returned to consenting participants through a bespoke return-of-result genomics clinic. Variant validation and subsequent clinical referral are advised as appropriate. The design and implementation of this flexible learning framework enables a cohort of detailed phenotyping and genotyping of healthy Singaporeans to be established and the frequency of disease-causing variants in this population to be determined. Our findings will contribute to international precision medicine initiatives, bridging gaps with ethnic-specific data and insights from this understudied population

Clinical Application of Computer-Aided Diagnostic System for Harmonious Introduction of Complementary Dialysis Therapy

In chronic peritoneal dialysis (PD) therapy, peritoneal permeability is gradually enhanced over the duration of the therapeutic course, leading to a grave decline in the therapeutic efficiency. In recent years, a novel therapy (CD therapy), which integrates PD therapy with hemodialysis therapy, is being applied to end-stage PD patients to complement the decline of therapeutic efficiency caused by the grave degeneration of the peritoneal tissue. To realize a harmonious introduction of the CD therapy, this study developed a useful index (KAu/c), which evaluates both therapeutic efficiency and degeneration of peritoneal tissue. Using a mathematical model and KAu/c, we were able to validate the therapeutic efficiency in the PD patients, and, in one case, propose a better prescription for the patient by employing the CD therapy. The clinical implementation of this methodology is indispensable with regard to expanding the therapeutic monitoring system for renal replacement therapy

Statement on bioinformatics and capturing the benefits of genome sequencing for society

The HUGO Committee on Ethics, Law and Society (CELS) undertook a Working Group exploration of the key ethical issues arising from genome sequencing in 2013. The Imagined Futures paper the group subsequently published proposed points to consider when applying genomic bioinformatics to data repositories used in genomic medicine and research ( http://www.hugo-international.org/Resources/Documents/CELS_Article-ImaginedFutures_2014.pdf ). Given the ever-increasing power to sequence the human genome rapidly and inexpensively-as well as trends toward "Big Data" and "Open Science"-we take this opportunity to update and refine the key findings of that paper

Ob’shtee zhitie

This feature, "ОБЬЩЕѤ ЖИТИѤ" [Ob'shtee zhitie], provides a list of ongoing projects and recent publications of scholars in the field of Early Slavic studies, arranged alphabetically by the country in which they work. Represented in this issue are reports from Canada, Great Britain, Hungary, the Netherlands, New Zealand, Romania, the Soviet Union, the United States of America, and Yugoslavia.In this feature, scholars have submitted lists of their publications or announced current projects underway. William R. Veder's report (82-84), however, also includes "Notes on an Archaeographic Expedition to Leningrad and Moscow (19 APr - 26 May 1982)." There are interesting editorial comments in a number of the entries and the two institutional reports concern access to the repositories' manuscripts. Regarding the Lenin Library (86): "The 'Literaturnaia gazeta' of 15 Sept 1982 contained a letter to the editors ... voicing serious concern with the effects of work in progress in the new metro-station 'Borovickaia' on the Pashkov House, where the Manuscript department is housed in one of the wings. If the Pashkov house were to suffer damage and need extensive repairs, the consequences for work on the manuscripts would be as serious as the recent 1 1/2 years' closure." The report from the State Historical Museum indicates that it will be closed for extensive renovation for as many as three years (86)

The Impact of a Filariasis Control Program on Lihir Island, Papua New Guinea

Large-scale intervention programmes to control filariasis are currently underway worldwide. However, a major unresolved question remains: what is the appropriate duration for these programmes? Recent theoretical work and clinical field experience has highlighted how the ecological diversity between different endemic regions hinders decision making processes of when to stop ongoing MDA programs. The goal of our study was to identify the factors determining success for a five year LF elimination program. We undertook different types of surveys together with a pre-existing MDA program in villages from two regions that had different infection prevalence rates. Our study shows that the five yearly cycles of MDA could neither eliminate the disease nor stop transmission in the high prevalence villages, such that low baseline lymphatic filariasis prevalence has a positive influence on the outcome of a program. Thus, the study provides data supporting the recommendation that in certain high prevalence and transmission environments more sustained efforts may be necessary

Towards a New Definition of Return-to-Work Outcomes in Common Mental Disorders from a Multi-Stakeholder Perspective

Objectives: To examine the perspectives of key stakeholders involved in the return-to-work (RTW) process regarding the definition of successful RTW outcome after sickness absence related to common mental disorders (CMD's). Methods: A mixed-method design was used: First, we used qualitative methods (focus groups, interviews) to identify a broad range of criteria important for the definition of successful RTW (N = 57). Criteria were grouped into content-related clusters. Second, we used a quantitative approach (online questionnaire) to identify, among a larger stakeholder sample (N = 178), the clusters and criteria most important for successful RTW. Results: A total of 11 clusters, consisting of 52 unique criteria, were identified. In defining successful RTW, supervisors and occupational physicians regarded "Sustainability'' and "At-work functioning" most important, while employees regarded "Sustainability," "Job satisfaction," "Work-home balance,'' and " Mental Functioning" most important. Despite agreement on the importance of certain criteria, considerable differences among stakeholders were observed. Conclusions: Key stakeholders vary in the aspects and criteria they regard as important when defining successful RTW after CMD-related sickness absence. Current definitions of RTW outcomes used in scientific research may not accurately reflect these key stakeholder perspectives. Future studies should be more aware of the perspective from which they aim to evaluate the effectiveness of a RTW intervention, and define their RTW outcomes accordingly