Working group 3: What are and how do we measure the pros and cons of existing approaches?

WG3 discussed both the pros and cons of existing schemes as well as metrics to measure relative advantages and disadvantages. We first provide a list of the current operational techniques and their respective advantages and disadvantages that were discussed in the WG. We do not claim that the list is complete, and we note that the pros and cons are neither exhaustive nor quantitative. Nevertheless, it may be useful to note the WG’s consensus on the general advantages and disadvantages of the most commonly-used schemes. We then list our recommendations for evaluating model uncertainty schemes. At the end is a short list pertaining to recommendations for further development of methods to represent model uncertainty

Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression

Based on an increased frequency of early death (death within the first treatment cycle) in our two latest randomized trials of combination chemotherapy in small-cell lung cancer (SCLC), we wanted to identify patients at risk of early non-toxic death (ENTD) and early toxic death (ETD). Data were stored in a database and logistic regression analyses were performed to identify predictive factors for early death. During the first cycle, 118 out of 937 patients (12.6%) died. In 38 patients (4%), the cause of death was sepsis. Significant risk factors were age, performance status (PS), lactate dehydrogenase (LDH) and treatment with epipodophyllotoxins and platinum in the first cycle (EP). Risk factors for ENTD were age, PS and LDH. Extensive stage had a hazard ratio of 1.9 (P = 0.07). Risk factors for ETD were EP, PS and LDH, whereas age and stage were not. For EP, the hazard ratio was as high as 6.7 (P = 0.0001). We introduced a simple prognostic algorithm including performance status, LDH and age. Using a prognostic algorithm to exclude poor-risk patients from trials, we could minimize early death, improve long-term survival and increase the survival differences between different regimens. We suggest that other groups evaluate our algorithm and exclude poor prognosis patients from trials of dose intensification. © 1999 Cancer Research Campaig

Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation : lesson from the nationwide study

Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p  21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT

Family Business Restructuring:A Review and Research Agenda

Although business restructuring occurs frequently and it is important for the prosperity of family firms across generations, research on family firms has largely evolved separately from research on business restructuring. This is a missed opportunity, since the two domains are complementary, and understanding the context, process, content, and outcome dimensions is relevant to both research streams. We address this by examining the intersection between research on business restructuring and family firms to improve our knowledge of each area and inform future research. To achieve this goal, we review and organize research across different dimensions to create an integrative framework. Building on current research, we focus on 88 studies at the intersection of family firm and business restructuring research to develop a model that identifies research needs and suggests directions for future research

Hot Mix Asphalt with High RAP Content

AbstractDue to increasing cost of asphalt binder, significant economic savings can be realized using high content of reclaimed asphalt pavement (RAP) in the production of new hot mix asphalt (HMA). Moreover, this is an environmentally friendly alternative as it reduces the need for virgin materials. It has to be noted that in Latvia RAP is rarely used in production of HMA and this valuable material is mostly degraded for use in lower value applications. Three mixtures were designed, which were the combination of two different RAP sources and local dolomite aggregates. The RAP binder had significantly aged having penetration of around 38mm, softening point of 56°C and Fraass temperature of -10°C. RAP was added at rates 30% and 50% for each RAP source. A softer binder grade (70/100 versus traditional 50/70) was added to compensate for the aged RAP binder. Hamburg wheel tracking test results demonstrated that all mixtures have high rutting resistance and fatigue test results using four-point bending beam were similar to those of virgin mixture. This demonstrated that mixtures with high RAP content can be successfully designed to meet the local volumetric and performance-specification requirements