27 research outputs found

    Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

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    https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd

    Cellular internalization of Bortezomib loaded CS MNPs by cervical cancer cells

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    FEBS EMBO 2014 Conference -- AUG 30-SEP 04, 2014 -- Paris, FRANCEWOS: 000359666803040…FEBS, EMB

    PAMAM Dendrimer Coated MNPs for siRNA Delivery and Gene Silencing

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    In this study, superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation method. The synthesized nanoparticles were modified with aminopropyl-trimethoxysilane for dendrimer coating. Aminosilane-modified MNPs were coated with PAMAM dendrimer. Gene silencing effect of Survivin siRNA loaded nanoparticles (NPs) were studied on Doxorubicin resistant MCF-7 cell lines. Consequently, Survivin siRNA were triggered cell death when delivered by G4 PAMAM dendrimer coated magnetic nanoparticles. Survivin siRNA loaded G4 MNPs facilitate to overcome drug resistance on Doxorubicin resistant breast cancer cells
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