512 research outputs found
The Onset of Phase Transitions in Condensed Matter and Relativistic QFT
Kibble and Zurek have provided a unifying causal picture for the appearance
of topological defects like cosmic strings or vortices at the onset of phase
transitions in relativistic QFT and condensed matter systems respectively.
There is no direct experimental evidence in QFT, but in condensed matter the
predictions are largely, but not wholly, supported in superfluid experiments on
liquid helium. We provide an alternative picture for the initial appearance of
strings/vortices that is commensurate with all the experimental evidence from
condensed matter and consider some of its implications for QFT.Comment: 37 pages, to be published in Condensed Matter Physics, 200
FORMULATION AND IN VITRO IN VIVO EVALUATION OF BOSENTAN PELLETS FOR PROLONGED DRUG RELEASE
Objective: The objective of this study was to develop extended release (ER) pellets of Bosentan, an endothelin receptor antagonist using fluid bed processor (coating).Method: The ER drug pellets of Bosentan were prepared using fluid bed coating. These drug-loaded pellets were further coated with ethyl cellulose of two viscosity grades and Eudragit as rate controlling polymers individual and in combination, hypromellose as pore former and binder, acetyl tributyl citrate as plasticizer, and magnesium stearate as anti-adhering agent.Results: The drug release was extended up to 24 h, and the drug release was mainly depends on the polymer type and polymer proportion. In vivo study of Bosentan, ER pellets were performed in healthy rabbits (New Zealand, White) of either sex weighing (3.0–3.3 kg) and were divided into two separate groups, each group consisting of 6 animals. Maximum plasma concentration (Cmax), maximum time (Tmax), area under the curve (AUC0-t), elimination rate constant (Kel), and half-life (T1/2) were studied for optimized formulation. Formulation was releasing the drug for a prolonged period of time.Conclusion: By the above results, it was observed that the prepared pellets could release the drug for an extended period when compared with the conventional dosage form of Bosentan, optimized formulation was shown longer half-life and Cmax indicates its acceptability. Finally, ER pellets of Bosentan were prepared for the treatment of pulmonary artery hypertension by fluid bed processor
Slow Quenches Produce Fuzzy, Transient Vortices
We examine the Zurek scenario for the production of vortices in quenches of
liquid in the light of recent experiments. Extending our previous
results to later times, we argue that short wavelength thermal fluctuations
make vortices poorly defined until after the transition has occurred. Further,
if and when vortices appear, it is plausible that that they will decay faster
than anticipated from turbulence experiments, irrespective of quench rates.Comment: 4 pages, Revtex file, no figures Apart from a more appropriate title,
this paper differs from its predecessor by including temperature, as well as
pressure, quenche
A thermodynamic framework to develop rate-type models for fluids without instantaneous elasticity
In this paper, we apply the thermodynamic framework recently put into place
by Rajagopal and co-workers, to develop rate-type models for viscoelastic
fluids which do not possess instantaneous elasticity. To illustrate the
capabilities of such models we make a specific choice for the specific
Helmholtz potential and the rate of dissipation and consider the creep and
stress relaxation response associated with the model. Given specific forms for
the Helmholtz potential and the rate of dissipation, the rate of dissipation is
maximized with the constraint that the difference between the stress power and
the rate of change of Helmholtz potential is equal to the rate of dissipation
and any other constraint that may be applicable such as incompressibility. We
show that the model that is developed exhibits fluid-like characteristics and
is incapable of instantaneous elastic response. It also includes Maxwell-like
and Kelvin-Voigt-like viscoelastic materials (when certain material moduli take
special values).Comment: 18 pages, 5 figure
Development of three dimensional constitutive theories based on lower dimensional experimental data
Most three dimensional constitutive relations that have been developed to
describe the behavior of bodies are correlated against one dimensional and two
dimensional experiments. What is usually lost sight of is the fact that
infinity of such three dimensional models may be able to explain these
experiments that are lower dimensional. Recently, the notion of maximization of
the rate of entropy production has been used to obtain constitutive relations
based on the choice of the stored energy and rate of entropy production, etc.
In this paper we show different choices for the manner in which the body stores
energy and dissipates energy and satisfies the requirement of maximization of
the rate of entropy production that leads to many three dimensional models. All
of these models, in one dimension, reduce to the model proposed by Burgers to
describe the viscoelastic behavior of bodies.Comment: 23 pages, 6 figure
A model for the degradation of polyimides due to oxidation
Polyimides, due to their superior mechanical behavior at high temperatures,
are used in a variety of applications that include aerospace, automobile and
electronic packaging industries, as matrices for composites, as adhesives etc.
In this paper, we extend our previous model in [S. Karra, K. R. Rajagopal,
Modeling the non-linear viscoelastic response of high temperature polyimides,
Mechanics of Materials, In press, doi:10.1016/j.mechmat.2010.09.006], to
include oxidative degradation of these high temperature polyimides. Appropriate
forms for the Helmholtz potential and the rate of dissipation are chosen to
describe the degradation. The results for a specific boundary value problem,
using our model compares well with the experimental creep data for PMR-15 resin
that is aged in air.Comment: 13 pages, 2 figures, submitted to Mechanics of Time-dependent
Material
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