BRST Gauge Fixing and Regularization

In the presence of consistent regulators, the standard procedure of BRST gauge fixing (or moving from one gauge to another) can require non-trivial modifications. These modifications occur at the quantum level, and gauges exist which are only well-defined when quantum mechanical modifications are correctly taken into account. We illustrate how this phenomenon manifests itself in the solvable case of two-dimensional bosonization in the path-integral formalism. As a by-product, we show how to derive smooth bosonization in Batalin-Vilkovisky Lagrangian BRST quantization.Comment: LaTeX, 12 page

Integrating short-term demand response into long-term investment planning

Planning models have been used for many years to optimize generation investments in electric power systems. More recently, these models have been extended in order to treat demand-side management on an equal footing. This paper stresses the importance of integrating short-term demand response to time-varying prices into those investment models. Three different methodologies are suggested to integrate short-term responsiveness into a long-term model assuming that consumer response can be modelled using price-elastic demand and that generators behave competitively. First, numerical results show that considering operational constraints in an investment model results in less inflexible base load capacity and more mid-range capacity that has higher ramp rates. Then, own-price and cross-price elasticities are included in order to incorporate consumers’ willingness to adjust the demand profile in response to price changes. Whereas own-price elasticities account for immediate response to price signals, cross-price elasticities account for shifting loads to other periods. As energy efficiency programs sponsored by governments or utilities also influence the load profile, the interaction of energy efficiency expenditures and demand response is also modelled. In particular, reduced responsiveness to prices can be a side effect when consumers have become more energy efficient. Comparison of model results for a single year optimization with and without demand response shows the peak reduction and valley filling effects of response to real-time prices for an illustrative example with a large amount of wind power injections. Additionally, increasing demand elasticity increases the optimal amount of installed wind power capacity. This suggests that demand-side management can result in environmental benefits not only through reducing energy use, but also by facilitating integration of renewable energy

The regularized BRST Jacobian of pure Yang-Mills theory

The Jacobian for infinitesimal BRST transformations of path integrals for pure Yang-Mills theory, viewed as a matrix \unity +\Delta J in the space of Yang-Mills fields and (anti)ghosts, contains off-diagonal terms. Naively, the trace of $\Delta J$ vanishes, being proportional to the trace of the structure constants. However, the consistent regulator \cR, constructed from a general method, also contains off-diagonal terms. An explicit computation demonstrates that the regularized Jacobian Tr\ \Delta J\exp -\cR /M^2 for $M^2\rightarrow \infty$ is the variation of a local counterterm, which we give. This is a direct proof at the level of path integrals that there is no BRST anomaly.Comment: 12 pages, latex, CERN-TH.6541/92, KUL-TF-92/2

Relative efficacy of psychotherapy and pharmacotherapy in the treatment of depression; a meta-analysis,

Abstract We investigated the efficacy of pharmacotherapy and psychotherapy for depression by searching for RCT's. Studies were classified according to chronicity and severity and a meta-analysis was applied. Ten studies were included. Remission did not differ between psychotherapy (38%) and pharmacotherapy (35%). No differences were found in chronic, or in non-chronic depression, and in mild or in moderate depression. Both treatments performed better in mild than in moderate depression. Dropout was larger in pharmacotherapy (28%) than in psychotherapy (24%). At follow-up relapse in pharmacotherapy (57%) was higher than in psychotherapy (27%). Psychotherapy and pharmacotherapy appear equally efficacious in depression. Both treatments have larger effects in mild than in moderate depression, but similar effects in chronic and non-chronic depression and at follow-up psychotherapy outperforms pharmacotherapy

Progrès récents dans la connaissance des bourdons du genre Bombus Latreille sensu stricto (Hymenoptera, Apidae, Bombinae)

peer reviewe

Hiding Anomalies

Anomalies can be anticipated at the classical level without changing the classical cohomology, by introducing extra degrees of freedom. In the process, the anomaly does not quite disappear. We show that, in fact, it is shifted to new symmetries that come with the extra fields.Comment: 10

Multisystem proteinopathy due to a homozygous p.Arg159His VCP mutation : a tale of the unexpected

ObjectiveTo assess the clinical, radiologic, myopathologic, and proteomic findings in a patient manifesting a multisystem proteinopathy due to a homozygous valosin-containing protein gene (VCP) mutation previously reported to be pathogenic in the heterozygous state.MethodsWe studied a 36-year-old male index patient and his father, both presenting with progressive limb-girdle weakness. Muscle involvement was assessed by MRI and muscle biopsies. We performed whole-exome sequencing and Sanger sequencing for segregation analysis of the identified p.Arg159His VCP mutation. To dissect biological disease signatures, we applied state-of-the-art quantitative proteomics on muscle tissue of the index case, his father, 3 additional patients with VCP-related myopathy, and 3 control individuals.ResultsThe index patient, homozygous for the known p.Arg159His mutation in VCP, manifested a typical VCP-related myopathy phenotype, although with a markedly high creatine kinase value and a relatively early disease onset, and Paget disease of bone. The father exhibited a myopathy phenotype and discrete parkinsonism, and multiple deceased family members on the maternal side of the pedigree displayed a dementia, parkinsonism, or myopathy phenotype. Bioinformatic analysis of quantitative proteomic data revealed the degenerative nature of the disease, with evidence suggesting selective failure of muscle regeneration and stress granule dyshomeostasis.ConclusionWe report a patient showing a multisystem proteinopathy due to a homozygous VCP mutation. The patient manifests a severe phenotype, yet fundamental disease characteristics are preserved. Proteomic findings provide further insights into VCP-related pathomechanisms

Regularisation, the BV method, and the antibracket cohomology

We review the Lagrangian Batalin--Vilkovisky method for gauge theories. This includes gauge fixing, quantisation and regularisation. We emphasize the role of cohomology of the antibracket operation. Our main example is $d=2$ gravity, for which we also discuss the solutions for the cohomology in the space of local integrals. This leads to the most general form for the action, for anomalies and for background charges.Comment: 12 pages, LaTeX, Preprint-KUL-TF-94/2