Processing of low level signals in mixed signal environment - a hardware design for better performance

The low level signals faces many problems during their processing and digitization. The main affecting factor is the added noise during its propagation in mixed signal environment which makes very difficult to extract exact information from the signal. Additionally hardware requirement increases when we want to process these kinds of signals. In this paper, we proposed a customized hardware for this purpose. This hardware caters the problems of noise, signal integrity issues and crosstalk which directly effectsembedded circuit efficiency. The board has all the options to cater the situation where the requiredsignal is buried in the noise or having very low level amplitude. Noise elimination and crosstalk isavoided in this hardware which include high speed Field Programmable gate Array (FPGA)

Comprehensive analysis of temporal alterations in cellular proteome of bacillus subtilis under curcumin treatment

Curcumin is a natural dietary compound with antimicrobial activity against various gram positive and negative bacteria. This study aims to investigate the proteome level alterations in Bacillus subtilis due to curcumin treatment and identification of its molecular/cellular targets to understand the mechanism of action. We have performed a comprehensive proteomic analysis of B. subtilis AH75 strain at different time intervals of curcumin treatment (20, 60 and 120 min after the drug exposure, three replicates) to compare the protein expression profiles using two complementary quantitative proteomic techniques, 2D-DIGE and iTRAQ. To the best of our knowledge, this is the first comprehensive longitudinal investigation describing the effect of curcumin treatment on B. subtilis proteome. The proteomics analysis revealed several interesting targets such UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, putative septation protein SpoVG and ATP-dependent Clp protease proteolytic subunit. Further, in silico pathway analysis using DAVID and KOBAS has revealed modulation of pathways related to the fatty acid metabolism and cell wall synthesis, which are crucial for cell viability. Our findings revealed that curcumin treatment lead to inhibition of the cell wall and fatty acid synthesis in addition to differential expression of many crucial proteins involved in modulation of bacterial metabolism. Findings obtained from proteomics analysis were further validated using 5-cyano-2,3-ditolyl tetrazolium chloride (CTC) assay for respiratory activity, resazurin assay for metabolic activity and membrane integrity assay by potassium and inorganic phosphate leakage measurement. The gene expression analysis of selected cell wall biosynthesis enzymes has strengthened the proteomics findings and indicated the major effect of curcumin on cell division

Impact of sandstone quarrying on the catchment area of balsamand-lake in jodhpur city, India

Scarcity of drinking water is one of the major problems in the sun-city Jodhpur, Many lakes situated in the outskirts of Jodhpur have been serving water to this city for several years. But the existence of these ancient reservoirs is being endangered due to unplanned and injudicious sandstone quarrying within their catchment area. The quarrying activities are continuously changing the land-profile. Hence, the direction of slope of the catchments area of these reservoirs is also being disturbed by large mined out pits and waste dumps. A huge amount of rainwater gets logged in these giant pits instead of feeding the reservoirs named Balsamand, kayalana, kaliberi, etc. As a result of this, these water reservoirs dry up after every two to three years. Day by day severity of this problem is increasing due to increase in quarrying activities in the catchments area. The type of topography that has resulted after quarrying leads to the process of devegetation. This phenomenon increases the hot plate effect in the eco-system leading to the hydrological imbalance. Therefore, it is essential to study how the water resources of the area can be protected if not improved by doing the planned quarrying operation. This paper highlights a case study conducted in the catchment area of Balsamand lake, which is 11km far from Jodhpur city. The objective of the study was to determine the extent of impact of mining activities on natural drainage system, so that suitable measures may be taken within time to restore the natural drainage pattern of the lake. Further recommendations are given to restore the natural drainage system and reduce the water logging in pits

(3-Methyl-3a,4,7,7a-tetrahydro-5H-4,7-methanoisoxazolo[4,5-d][1,2]oxazin-5-yl)(phenyl)methanone

The title compound, C14H14N2O3, is the exo isomer with a syn arrangement of two O atoms in the isoxazole and oxazine rings. The dihedral angle between the isoxazole and phenyl rings is 60.38 (4)°. In the crystal, weak C—H...O hydrogen bonds link the molecules, forming a three-dimensional network. The isoxazole O atom is an acceptor for three of these hydrogen bonds

5,8-Dimethoxy-3,9-dimethyl-3a,4,9,9a-tetrahydro-4,9-epoxynaphtho[2,3-d]isoxazole

The title compound, C15H17NO4, is the exo isomer with a syn arrangement of the O atom in the isoxazole ring to the methyl group of the bicyclic alkene. The dihedral angle between the isoxazole ring and the benzene ring is 7.42 (9)°. In the crystal, weak C—H...O hydrogen bonds link molecules, forming a three-dimensional network. The isoxazole O atom is an acceptor for both weak hydrogen bonds

1-(3-Hydroxy-5,8-dimethoxy-4-methyl-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-2-yl)ethan-1-one

The stereochemistry and regioschemistry (exo) of the title compound, C15H18O5, were determined by the X-ray analysis. The methoxy groups essentially lie in the plane of the benzene ring to which they are attached, as described by the C—O—C...;C torsion angles of −176.80 (12) and 4.67 (19)°. In the crystal, O—H...O hydrogen bonds and weak C—H...O hydrogen bonds link the molecules, forming chains of R21(8) rings along [010]

N–O Cleavage reactions of heterobicycloalkene-fused 2-isoxazolines

Transition metal-mediated N–O bond cleavage reactions of heterobicycloalkene-fused 3-methyl-2-isoxazolines were investigated. Optimal cleavage conditions were found with Raney nickel/AlCl3 mediation in aqueous methanol. The reaction provided a diverse collection of novel heterobicycle-fused β-hydroxyketones with good to excellent yields (66–95%) and without the need for chromatographic purification

Alterations in RAPD profiles of proliferating shootlets of sugarcane in response to thidiazuron

207-210Proliferating shootlets of sugarcane varieties CoH 92 and Co 7717, raised from apical meristems, were cultured in vitro for 24 d in MS medium with different concentration of TDZ. DNA from leaves of these shootlets was extracted and amplified using 10 random decamer primers. A total of 50 RAPD products in var. CoH 92 and 43 in var. Co 7717 were formed. TDZ caused considerable differences in amplification products of both varieties. Several RAPD products, which were absent in control plantlets, amplified in TDZ treatments, such as 950 bp (CoH 92 and Co 7717) against primer 5´-AATCGGGCTG-3´ (10A04); 1200 bp (Co 7717) against primer 5´-AGCCAGCGAA-3´ (50A16); 1150 and 1000 bp (CoH 92 and Co 7717) and 900 bp (Co 7717) against primer 5´-CTGCTGGGAC-3´ (80B10); 950 bp (CoH-92) and 500 bp (Co 7717) against primer 5´-GTAGACCCGT-3´ (90B11); and 500 bp (CoH 92) against primer 5´-CCGCATCTAC-3´ (100C04). On the other hand, certain RAPD products, such as 220 bp (CoH 92) against primer 5´-TCGGCGATAG-3´ (40A10); 950 bp (Co 7717) against primer 50A16; 550, 360 and 320 bp (CoH 92) against primer 5´-GGACTGGAGT-3´ (60B04); and 1050 bp (CoH 92) against primer 80B10, amplified in the control plantlets disappeared due to TDZ treatments. Such altered RAPD profile in response to TDZ is an entirely new and hitherto unsuspected observation, which suggests a possible genetic change or perhaps to a synthesis of protein or non-protein regulators that affect the process of DNA synthesis/amplification