External loading determines specific ECM genes regulation

Bio artificial matrices embedded with cells are simulated in bioreactors to facilitate ECM production. As cells attach, they develop forces, which are dependent on cell type and matrix stiffness. External forces (i.e strain), however, are critical for tissue homeostasis and elicit specific cellular responses, such as gene expression and protein production. Collagen Type I is a widely used scaffold in Tissue engineering. The aim of this study was to study the mechanical and molecular responses, of different cell types to increasing collagen substrate stiffness

Sisyphus effects in a microwave-excited flux-qubit resonator system

Sisyphus amplification, familiar from quantum optics, has recently been reported as a mechanism to explain the enhanced quality factor of a classical resonant (tank) circuit coupled to a superconducting flux qubit. Here we present data from a coupled system, comprising a quantum mechanical rf SQUID (flux qubit) reactively monitored by an ultrahigh quality factor noise driven rf resonator and excited by microwaves. The system exhibits enhancement of the tank-circuit resonance, bringing it significantly closer (within 1%) to the lasing limit, than previously reported results. 2010 The American Physical Society

Surface enhancement of oxygen exchange and diffusion in the ionic conductor La2Mo2O9

Isotopic surface oxygen exchange and its subsequent diffusion have been measured using secondary ion mass spectrometry in the fast ionic conductor La2Mo2O9. A silver coating was applied to the sample surface to enhance the surface exchange process for dry oxygen. Contrary to previous studies performed using a wet atmosphere, no grain boundary diffusion tail was observed under these optimized dry exchange conditions. The activation energy for oxygen diffusion was found to be 0.66(+/- 0.09) eV at high temperature (>570 degrees C), and 1.25(+/- 0.01)eV at low temperature (<570 degrees C). Time-of-Flight secondary ion mass spectrometry was employed to investigate the correlation between the silver coating and the O-18 concentration on the sample surface. A close correlation between the presence of silver and oxygen incorporation on the surface was observed. (C) 2010 Elsevier B.V. All rights reserved

Getting the most from medical VOC data using Bayesian feature learning

The metabolic processes in the body naturally produce a diverse set of Volatile Organic Compounds (VOCs), which are excreted in breath, urine, stool and other biological samples. The VOCs produced are odorous and influenced by disease, meaning olfaction can provide information on a person’s disease state. A variety of instruments exist for performing “artificial olfaction”: measuring a sample, such as patient breath, and producing a high dimensional output representing the odour. Such instruments may be paired with machine learning techniques to identify properties of interest, such as the presence of a given disease. Research shows good disease-predictive ability of artificial olfaction instrumentation. However, the statistical methods employed are typically off-the-shelf, and do not take advantage of prior knowledge of the structure of the high dimensional data. Since sample sizes are also typically small, this can lead to suboptimal results due to a poorly-learned model. In this thesis we explore ways to get more out of artificial olfaction data. We perform statistical analyses in a medical setting, investigating disease diagnosis from breath, urine and vaginal swab measurements, and illustrating both successful identification and failure cases. We then introduce two new latent variable models constructed for dimension reduction of artificial olfaction data, but which are widely applicable. These models place a Gaussian Process (GP) prior on the mapping from latent variables to observations. Specifying a covariance function for the GP prior is an intuitive way for a user to describe their prior knowledge of the data covariance structure. We also enable an approximate posterior and marginal likelihood to be computed, and introduce a sparse variant. Both models have been made available in the R package stpca hosted at https://github.com/JimSkinner/stpca. In experiments with artificial olfaction data, these models outperform standard feature learning methods in a predictive pipeline

Spatial structures in a simple model of population dynamics for parasite-host interactions

Spatial patterning can be crucially important for understanding the behavior of interacting populations. Here we investigate a simple model of parasite and host populations in which parasites are random walkers that must come into contact with a host in order to reproduce. We focus on the spatial arrangement of parasites around a single host, and we derive using analytics and numerical simulations the necessary conditions placed on the parasite fecundity and lifetime for the populations long-term survival. We also show that the parasite population can be pushed to extinction by a large drift velocity, but, counterintuitively, a small drift velocity generally increases the parasite population.Comment: 6 pages, 6 figure

The New Zealand Strong Motion Earthquake Recorder Network

The network of strong-motion earthquake recorders, maintained throughout New Zealand by the Engineering Seismology Section of the Department of Scientific and Industrial Research, is described. The instruments are either deployed as ground instruments to measure potential earthquake attack on structures, or in structures, e.g. buildings, dams and industrial installations, to record structural response. Details are given of installation of instruments , maintenance, laboratory work, record retrieval and digitisation, costs and staffing for the network. Future developments mooted include an improved digitising system, the introduction of an improved version of the existing mechanical-optical instrument in 1979, and, in the long term, the introduction of an entirely new digital recorder, having an electrical output from its accelerometers, which will make possible the transmission of data by telephone or radio link

Development of lanthanum nickelate as a cathode for use in intermediate temperature solid oxide fuel cells

The performance of lanthanum nickelate, La2NiO4+δ (LNO), as a cathode in IT-SOFCs with the electrolyte cerium gadolinium oxide, Ce0.9Gd0.1O2−δ (CGO), has been investigated by AC impedance spectroscopy of symmetrical cells. A significant reduction in the area specific resistance (ASR) has been achieved with a layered cathode structure consisting of a thin compact LNO layer between the dense electrolyte and porous electrode. This decrease in ASR is believed to be a result of contact at the electrolyte/cathode boundary enhancing the oxygen ion transfer to the electrolyte. An ASR of 1.0 Ω cm2 at 700 °C was measured in a symmetrical cell with this layered structure, compared to an ASR of 7.4 Ω cm2 in a cell without the compact layer. In addition, further improvements were observed by enhancing the cell current collection and it is anticipated that a symmetrical cell consisting of a layered structure with adequate current collection would lower these ASR values further

NICMOS Observations of the Pre-Main-Sequence Planetary Debris System HD 98800

Spectral energy distributions (SEDs) from 0.4 to 4.7 microns are presented for the two principal stellar components of HD~98800, A and B. The third major component, an extensive planetary debris system (PDS), emits > 20% of the luminosity of star B in a blackbody SED at 164 +/- 5K extending from mid-IR to millimeter-wavelengths. At 0.95 microns a preliminary upper limit of < 0.06 is obtained for the ratio of reflected light to the total from star B. This result limits the albedo of the PDS to < 0.3. Values are presented for the temperature, luminosity, and radius of each major systemic component. Remarkable similarities are found between the PDS and the interplanetary debris system around the Sun as it could have appeared a few million years after its formation.Comment: LaTeX, 9 pages with 1 encapsulated postscript figure and one specially formatted Table which is rendered as a postscript file and included as a figure. Accepted for publication in Astrophysical Journal Letter