Bio artificial matrices embedded with cells are simulated in bioreactors to
facilitate ECM production. As cells attach, they
develop forces, which are dependent on cell type
and matrix stiffness. External forces (i.e strain),
however, are critical for tissue homeostasis and
elicit specific cellular responses, such as gene
expression and protein production. Collagen Type
I is a widely used scaffold in Tissue engineering.
The aim of this study was to study the mechanical
and molecular responses, of different cell types to
increasing collagen substrate stiffness
