Universal Amplitude Ratios in the Ising Model in Three Dimensions

We use a high-precision Monte Carlo simulation to determine the universal specific-heat amplitude ratio A+/A- in the three-dimensional Ising model via the impact angle \phi of complex temperature zeros. We also measure the correlation-length critical exponent \nu from finite-size scaling, and the specific-heat exponent \alpha through hyperscaling. Extrapolations to the thermodynamic limit yield \phi = 59.2(1.0) degrees, A+/A- = 0.56(3), \nu = 0.63048(32) and \alpha = 0.1086(10). These results are compatible with some previous estimates from a variety of sources and rule out recently conjectured exact values.Comment: 17 pages, 5 figure

On the low-temperature phase of the three-state antiferromagnetic Potts model on the simple cubic lattice

The three-state antiferromagnetic Potts model on the simple cubic lattice is investigated using the cluster variation method in the cube and the star-cube approximations. The broken-sublattice-symmetry phase is found to be stable in the whole low-temperature region, contrary to previous results obtained using a modified cluster variation method. The tiny free energy difference between the broken-sublattice-symmetry and the permutationally-symmetric-sublattices phases is calculated in the two approximations and turns out to be smaller in the (more accurate) star-cube approximation than in the cube one.Comment: 4 pages REVTeX + 2 PostScript figures, to be published in Phys. Rev. E as a Rapid Communicatio

Quantum Ising model in a transverse random field: A density-matrix renormalization group analysis

The spin-1/2 quantum Ising chain in a transverse random magnetic field is studied by means of the density-matrix renormalization group. The system evolves from an ordered to a paramagnetic state as the amplitude of the random field is increased. The dependence of the magnetization on a uniform magnetic field in the z direction and the spontaneous magnetization as a function of the amplitude of the transverse random magnetic field are determined. The behavior of the spin-spin correlation function both above and at criticality is studied. The scaling laws for magnetization and correlation functions are tested against previous numerical and renormalization-group results.Comment: 5 pages with 7 figures inside them, proper format of authors' names use

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.

ObjectiveTofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the effects on gene expression in situ are unknown. Therefore, tofacitinib effects on synovial pathobiology were investigated.MethodsA randomised, double-blind, phase II serial synovial biopsy study (A3921073; NCT00976599) in patients with RA with an inadequate methotrexate response. Patients on background methotrexate received tofacitinib 10 mg twice daily or placebo for 28 days. Synovial biopsies were performed on Days -7 and 28 and analysed by immunoassay or quantitative PCR. Clinical response was determined by disease activity score and European League Against Rheumatism (EULAR) response on Day 28 in A3921073, and at Month 3 in a long-term extension study (A3921024; NCT00413699).ResultsTofacitinib exposure led to EULAR moderate to good responses (11/14 patients), while placebo was ineffective (1/14 patients) on Day 28. Tofacitinib treatment significantly reduced synovial mRNA expression of matrix metalloproteinase (MMP)-1 and MMP-3 (p<0.05) and chemokines CCL2, CXCL10 and CXCL13 (p<0.05). No overall changes were observed in synovial inflammation score or the presence of T cells, B cells or macrophages. Changes in synovial phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT3 strongly correlated with 4-month clinical responses (p<0.002). Tofacitinib significantly decreased plasma CXCL10 (p<0.005) at Day 28 compared with placebo.ConclusionsTofacitinib reduces metalloproteinase and interferon-regulated gene expression in rheumatoid synovium, and clinical improvement correlates with reductions in STAT1 and STAT3 phosphorylation. JAK1-mediated interferon and interleukin-6 signalling likely play a key role in the synovial response.Trial registration numberNCT00976599

Topoisomer Differentiation of Molecular Knots by FTICR MS: Lessons from Class II Lasso Peptides

Lasso peptides constitute a class of bioactive peptides sharing a knotted structure where the C-terminal tail of the peptide is threaded through and trapped within an N-terminalmacrolactamring. The structural characterization of lasso structures and differentiation from their unthreaded topoisomers is not trivial and generally requires the use of complementary biochemical and spectroscopic methods. Here we investigated two antimicrobial peptides belonging to the class II lasso peptide family and their corresponding unthreaded topoisomers: microcin J25 (MccJ25), which is known to yield two-peptide product ions specific of the lasso structure under collisioninduced dissociation (CID), and capistruin, for which CID does not permit to unambiguously assign the lasso structure. The two pairs of topoisomers were analyzed by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) upon CID, infrared multiple photon dissociation (IRMPD), and electron capture dissociation (ECD). CID and ECDspectra clearly permitted to differentiate MccJ25 from its non-lasso topoisomer MccJ25-Icm, while for capistruin, only ECD was informative and showed different extent of hydrogen migration (formation of c\bullet/z from c/z\bullet) for the threaded and unthreaded topoisomers. The ECD spectra of the triply-charged MccJ25 and MccJ25-lcm showed a series of radical b-type product ions {\eth}b0In{\TH}. We proposed that these ions are specific of cyclic-branched peptides and result from a dual c/z\bullet and y/b dissociation, in the ring and in the tail, respectively. This work shows the potentiality of ECD for structural characterization of peptide topoisomers, as well as the effect of conformation on hydrogen migration subsequent to electron capture

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.

Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at very low levels in CSF and, to our knowledge, has never been measured previously

Three-coloring statistical model with domain wall boundary conditions. I. Functional equations

In 1970 Baxter considered the statistical three-coloring lattice model for the case of toroidal boundary conditions. He used the Bethe ansatz and found the partition function of the model in the thermodynamic limit. We consider the same model but use other boundary conditions for which one can prove that the partition function satisfies some functional equations similar to the functional equations satisfied by the partition function of the six-vertex model for a special value of the crossing parameter.Comment: 16 pages, notations changed for consistency with the next part, appendix adde

A Spin - 3/2 Ising Model on a Square Lattice

The spin - 3/2 Ising model on a square lattice is investigated. It is shown that this model is reducible to an eight - vertex model on a surface in the parameter space spanned by coupling constants J, K, L and M. It is shown that this model is equivalent to an exactly solvable free fermion model along two lines in the parameter space.Comment: LaTeX, 7 pages, 1 figure upon request; JETP Letters, in pres

Spanning tree generating functions and Mahler measures

We define the notion of a spanning tree generating function (STGF) $\sum a_n z^n$, which gives the spanning tree constant when evaluated at $z=1,$ and gives the lattice Green function (LGF) when differentiated. By making use of known results for logarithmic Mahler measures of certain Laurent polynomials, and proving new results, we express the STGFs as hypergeometric functions for all regular two and three dimensional lattices (and one higher-dimensional lattice). This gives closed form expressions for the spanning tree constants for all such lattices, which were previously largely unknown in all but one three-dimensional case. We show for all lattices that these can also be represented as Dirichlet $L$-series. Making the connection between spanning tree generating functions and lattice Green functions produces integral identities and hypergeometric connections, some of which appear to be new.Comment: 26 pages. Dedicated to F Y Wu on the occasion of his 80th birthday. This version has additional references, additional calculations, and minor correction

The effects of the spontaneous presence of a spouse/partner and others on cardiovascular reactions to an acute psychological challenge

The presence of supportive others has been associated with attenuated cardiovascular reactivity in the laboratory. The effects of the presence of a spouse and others in a more naturalistic setting have received little attention. Blood pressure and heart rate reactions to mental stress were recorded at home in 1028 married/partnered individuals. For 112 participants, their spouse/partner was present; for 78, at least one other person was present. Women tested with a spouse/partner present showed lower magnitude systolic blood pressure and heart rate reactivity than those tested without. Individuals tested with at least one nonspousal other present also displayed attenuated reactivity. This extends the results of laboratory studies and indicates that the spontaneous presence of others is associated with a reduction in cardiovascular reactivity in an everyday environment; spouse/partner presence would appear to be especially effective for women.\ud \u