An evaluation of the quality of statistical design and analysis of published medical research : results from a systematic survey of general orthopaedic journals

Background: The application of statistics in reported research in trauma and orthopaedic surgery has become ever more important and complex. Despite the extensive use of statistical analysis, it is still a subject which is often not conceptually well understood, resulting in clear methodological flaws and inadequate reporting in many papers. Methods: A detailed statistical survey sampled 100 representative orthopaedic papers using a validated questionnaire that assessed the quality of the trial design and statistical analysis methods. Results: The survey found evidence of failings in study design, statistical methodology and presentation of the results. Overall, in 17% (95% confidence interval; 10–26%) of the studies investigated the conclusions were not clearly justified by the results, in 39% (30–49%) of studies a different analysis should have been undertaken and in 17% (10–26%) a different analysis could have made a difference to the overall conclusions. Conclusion: It is only by an improved dialogue between statistician, clinician, reviewer and journal editor that the failings in design methodology and analysis highlighted by this survey can be addressed

Constraining Dark Photons with Self-consistent Simulations of Globular Cluster Stars

We revisit stellar constraints on dark photons. We undertake dynamical stellar evolution simulations which incorporate the resonant and off-resonant production of transverse and longitudinal dark photons. We compare our results with observables derived from measurements of globular cluster populations, obtaining new constraints based on the luminosity of the tip of the red-giant branch (RGB), the ratio of populations of RGB to horizontal branch (HB) stars (the $R$-parameter), and the ratio of asymptotic giant branch to HB stars (the $R_2$-parameter). We find that previous bounds derived from static stellar models do not capture the effects of the resonant production of light dark photons leading to overly conservative constraints, and that they over-estimate the effects of heavier dark photons on the RGB-tip luminosity. This leads to differences in the constraints of up to an order of magnitude in the kinetic mixing parameter.Comment: 15+7 pages, 11+2 figures, 0+4 table

The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast

The detection and amplification of extracellular signals requires the involvement of multiple protein components. In mammalian cells the receptor of activated C kinase (RACK1) is an important scaffolding protein for signal transduction networks. Further, it also performs a critical function in regulating the cell cycle by modulating the G1/S transition. Many eukaryotic cells express RACK1 orthologs, with one example being Cpc2p in the fission yeast Schizosaccharomyces pombe. In contrast to RACK1, Cpc2p has been described to positively regulate, at the ribosomal level, cells entry into M phase. In addition, Cpc2p controls the stress response pathways through an interaction with Msa2p, and sexual development by modulating Ran1p/Pat1p. Here we describe investigations into the role, which Cpc2p performs in controlling the G protein-mediated mating response pathway. Despite structural similarity to Gβ-like subunits, Cpc2p appears not to function at the G protein level. However, upon pheromone stimulation, cells overexpressing Cpc2p display substantial cell morphology defects, disorientation of septum formation and a significantly protracted G1 arrest. Cpc2p has the potential to function at multiple positions within the pheromone response pathway. We provide a mechanistic interpretation of this novel data by linking Cpc2p function, during the mating response, with its previous described interactions with Ran1p/Pat1p. We suggest that overexpressing Cpc2p prolongs the stimulated state of pheromone-induced cells by increasing ste11 gene expression. These data indicate that Cpc2p regulates the pheromone-induced cell cycle arrest in fission yeast by delaying cells entry into S phase

Benchmark models for the analysis and control of small-signal oscillatory dynamics in power systems

This paper summarizes a set of six benchmark systems for the analysis and control of electromechanical oscillations in power systems, recommended by the IEEE Task Force on Benchmark Systems for Stability Controls of the Power System Dynamic Performance Committee. The benchmark systems were chosen for their tutorial value and particular characteristics leading to control the system design problems relevant to the research community. For each benchmark, the modeling guidelines are provided, along with eigenvalues and time-domain results produced with at least two simulation softwares, and one possible control approach is provided for each system as well. Researchers and practicing engineers are encouraged to use these benchmark systems when assessing new oscillation damping control strategies

Advancing Globular Cluster Constraints on the Axion-Photon Coupling

We improve the current upper bound on the axion-photon coupling derived from stellar evolution using the $R_2$ parameter, the ratio of stellar populations on the Asymptotic Giant Branch to Horizontal Branch in Globular Clusters. We compare this with data from simulations using the stellar evolution code MESA which include the effects of axion production. Particular attention is given to quantifying in detail the effects of uncertainties on the $R$ and $R_2$ parameters due to the modelling of convective core boundaries. Using a semiconvective mixing scheme we constrain the axion-photon coupling to be $g_{a\gamma\gamma} < 0.47 \times 10^{-10}~\mathrm{GeV}^{-1}$. This rules out new regions of QCD axion and axion-like particle parameter space. Complementary evidence from asteroseismology suggests that this could improve to as much as $g_{a\gamma\gamma} < 0.34 \times 10^{-10}~\mathrm{GeV}^{-1}$ as the uncertainties surrounding mixing across convective boundaries are better understood.Comment: 7+8 pages, 3+1 figures, 1+2 table

The safety of peri-articular local anaesthetic injection for patients undergoing total knee replacement with autologous blood transfusion : a randomised trial

Intra-operative, peri-articular injection of local anaesthesia is an increasingly popular way of controlling pain following total knee replacement. At the same time, the problems associated with allogenic blood transfusion have led to interest in alternative methods for managing blood loss after total knee replacement, including the use of auto-transfusion of fluid from the patient’s surgical drain. It is safe to combine peri-articular infiltration with auto-transfusion from the drain. We performed a randomised clinical trial to compare the concentration of local anaesthetic in the blood and in the fluid collected in the knee drain in patients having either a peri-articular injection or a femoral nerve block. Clinically relevant concentrations of local anaesthetic were found in the fluid from the drains of patients having peri-articular injections (4.92 μg/ml (SD 3.151)). However, none of the patients having femoral nerve blockade had detectable levels. None of the patients in either group had clinically relevant concentrations of local anaesthetic in their blood after re-transfusion. The evidence from this study suggests that it is safe to use peri-articular injection in combination with auto-transfusion of blood from peri-articular drains during knee replacement surger