Attachment and substance use in adolescence: A review of conceptual and methodological aspects

Attachment is currently considered one of the major risk and/ or protective factors for substance use in adolescence. This paper reviews the most important studies published in the last 30 years in this field, focusing on the conceptual and methodological issues that may be making it more difficult to draw conclusions about the impact of attachment – especially attachment to parents – on substance use among youths. In general, the results indicate that secure attachment or stronger attachment between parents and children acts as a protective factor against drug use, even though there is a great variability in relation to the concept of addiction and its assessment. Secondly, most of the research reviewed also covers other factors that may be conditioning the influence of attachment to parents on children’s drug use and which would explain, at least in part, the disparity of the results from different studies. Notable among such factors would be individual characteristics (such as sex, age or self-esteem) and the influence of other sources of attachment, including peers and their circumstances (such as their drug use). Finally, we discuss the importance of taking into account the mentioned conceptual and methodological considerations aspects in research on attachment as a risk and/or protective factor for drug use in adolescence. El apego se considera actualmente uno de los mayores factores de riesgo y/o protección para el consumo de sustancias en la adolescencia. El presente trabajo revisa los estudios más importantes que se han publicado en los últimos 30 años al respecto, centrándose en aquellas cuestiones conceptuales y metodológicas que pueden estar dificultando concluir qué impacto ejerce el apego, sobre todo el apego a los padres, en el consumo de sustancias de los jóvenes. Los resultados indican, en general, que el apego seguro o un mayor apego entre padres e hijos actúa como factor de protección frente al consumo de drogas, si bien existe una gran variabilidad en torno al concepto de apego y su evaluación. En segundo lugar, la mayor parte de los estudios revisados incluyen además otros factores que pueden estar condicionando la influencia del apego a los padres en el consumo de drogas de los hijos y que explicarían, al menos en parte, la disparidad de los resultados en los distintos estudios. Entre estos factores destacarían las características individuales (como el sexo, la edad o la autoestima de los individuos), y la influencia de otras fuentes de apego, como los iguales y sus circunstancias, como por ejemplo el consumo de drogas por parte de éstos. Finalmente, se discute la importancia de tener en cuenta dichas consideraciones conceptuales y metodológicas en la investigación del apego como factor de riesgo y/o protección frente al consumo de drogas en la adolescencia

Chemically modified nanomaterials as lubricant additive: time stability, friction, and wear

This work reviews the results on the temporal stability of nanodispersions containing chemically modified nanoadditives: carbon-based nanomaterials, metals, metal oxides, metal sulfides, nanocomposites, among others. Morphology, size, coating type and concentration of the NPs as well as the viscosity of the base oil are the main characteristics that affect stability. Coated spherical NPs with mean diameter lower than 20 nm are the most common among those which led to nanolubricants with stabilities longer than two months. The tribological results of the nanolubricants with stabilities higher than one month are also reviewed. Regardless the base oil, chemically modified nanoparticles reduced wear more than friction, reaching reductions of friction up to 75% and wear volume up to 99%. As for the tribological mechanisms involving chemically modified nanoparticles, the formation of adsorbed or tribochemical reaction films on worn surfaces were reported more oftenThis work is supported by MCIN/AEI/10.13039/501100011033 and by the European Regional Development Fund (ERDF, FEDER in Spanish) through the ENE2017-86425-C2-2-R and the PID2020-112846RB-C22 projects as well as by Xunta de Galicia (ED431C 2020/10). JMLDR acknowledges the grant of the Margarita Salas program, funded by MCIN/AEI/10.13039/501100011033 and “NextGenerationEU/PRTR”S

Tribological properties of graphene nanoplatelets or boron nitride nanoparticles as additives of a polyalphaolefin base oil

In this work, antifriction and antiwear capabilities of hexagonal boron nitride nanoparticles (h-BN) or graphene nanoplatelets (GnP) as additives of a polyalphaolefin neat oil (PAO 40) were studied at pure sliding conditions. For this purpose, eight PAO 40 nanodispersions were prepared: four nanodispersions with h-BN and four others based on GnP. The mass concentrations of these dispersions are 0.25, 0.50, 0.75 and 1.00 wt% of h-BN and 0.05, 0.10. 0.25 and 0.50 wt% of GnP, having all of them a good stability against sedimentation (at least 96 h). Tribological assays were carried with prepared nanolubricants as well as with PAO 40 base oil at 20 N load. All nanolubricants based on h-BN or GnP showed lower friction coefficients in comparison to the non-additivated neat oil, with a maximum decrease in friction of 21% for the 0.50 wt% GnP nanodispersion. Regarding the produced wear, all disks lubricated with nanolubricants showed lower wear than those lubricated using PAO 40. The greatest wear reduction in wear track width (22%) was also achieved for the 0.50 wt% in GnP nanolubricant. Moreover, through the confocal Raman microscopy and roughness analyses of worn disks it can be concluded that the wear reductions are due to the surface repairing and tribofilm formation mechanismsS

Real-time single-exposure ROI-driven HDR adaptation based on focal-plane reconfiguration

Proc. SPIE 9400, Real-Time Image and Video Processing 2015This paper describes a prototype smart imager capable of adjusting the photo-integration time of multiple regions of interest concurrently, automatically and asynchronously with a single exposure period. The operation is supported by two interwined photo-diodes at pixel level and two digital registers at the periphery of the pixel matrix. These registers divide the focal-plane into independent regions within which automatic concurrent adjustment of the integration time takes place. At pixel level, one of the photo-diodes senses the pixel value itself whereas the other, in collaboration with its counterparts in a particular ROI, senses the mean illumination of that ROI. Additional circuitry interconnecting both photo-diodes enables the asynchronous adjustment of the integration time for each ROI according to this sensed illumination. The sensor can be recon gured on-the- y according to the requirements of a vision algorithm.España MINECO (FEDER) TEC2012-38921-C02 IPT-2011-1625-430000 IPC-20111009 CDTIJunta de Andalucía TIC 2338-2013 CEIC

Smoking cessation and depressive symptoms at 1-, 3-, 6-, and 12-months follow-up

Background The relationship between tobacco and depressive symptoms has been examined. However, there is little information on the evolution of these symptoms when an individual quits. The aim of this study was to analyze the evolution of depressive symptoms over time (pre-, post-treatment, 1-, 3-, 6-, and 12-months follow-up) in relation to smoking status 12 months after having received a psychological treatment for smoking cessation. Method The sample was made up of 242 adults who received cognitive-behavioral treatment for smoking cessation (64.4% women; mean age=41.71 years). The BDI-II was used to assess depressive symptomatology. Participants were classified into three groups according to smoking status at 12-months follow-up (abstainers, relapsers, and smokers). Results There were no significant differences in depressive symptoms among the three groups at pretreatment. At the end of treatment, abstainers and relapsers presented less depressive symptomatology than smokers. At follow-up, abstainers continued to present less depressive symptomatology than smokers, whereas in relapsers, symptoms began to increase as the relapses occurred. Regarding the evolution of depressive symptomatology, the abstainer and relapser groups showed a significant reduction at the end of treatment. Only in the group of abstainers did the decrease continue during 12 months follow-up. Limitations The decrease of the initial sample size from 562 to 242 participants. Variables such as self-esteem and self-efficacy were not assessed. Conclusions Smoking cessation is associated with a decrease in depressive symptomatology, that is maintained over time. In contrast, relapse is associated with an increase of such symptoms. These findings signify the potential importance of addressing depressive symptomatology in smoking cessation treatment

Control de calidad del seguimiento del embarazo normal en atención primaria

ObjetivosGeneral: aumentar la calidad de la atención maternoinfantil en nuestra población.Específicomejorar al menos un 10% el registro de las actividades con peor cumplimiento en la primera evaluación del ciclo de calidad.DiseñoCiclo de calidad del programa de seguimiento de embarazo normal en atención primaria (AP).Dimensión de calidad estudiadacientífico-técnica. Evaluación retrospectiva, cruzada, por iniciativa interna y sobre las historias clínicas de las gestantes. Marco temporal: primera evaluación sobre gestaciones de 1994-1995; aplicación de medidas correctoras durante 1996; segunda evaluación sobre gestaciones de 1997-1998.ÁmbitoAtención primaria.SujetosTodas las gestaciones seguidas en nuestro equipo de AP durante los períodos descritos.Mediciones y resultados principalesCriterios evaluados: actividades asistenciales del programa de seguimiento del embarazo normal del Área 10.Primera evaluación (n = 54)incumplimiento global del 11,5%; los criterios con cumplimiento inferior al 80% fueron suplemento con ácido fólico, consejos a la gestante, detección de diabetes gestacional y visita al mes posparto Segunda evaluación (n = 69) incumplimiento global del 6,3%; todas las actividades superaron el 80% excepto la exploración obstétrica en la primera visita, la visita a la semana posparto y la visita al mes posparto.ConclusionesTras la introducción de unas medidas correctoras sencillas, logramos una mejoría global superior al 40% y un aumento en el cumplimiento de la mayor parte de las actividades, excepto en las visitas posparto y la exploración obstétrica en la primera visita. Creemos que es necesario mantener un ciclo continuo de mejora de calidad para conseguir una adecuada asistencia maternoinfantil.ObjectivesGeneral: to increase the quality of mother-baby care in our population. Specific: to improve by at least 10% the record of activities with poorest compliance at the first evaluation on the quality cycle.DesignQuality cycle of the normal pregnancy monitoring programme in primary care (PC). The scientific-technical dimension of quality was the one studied. There was a retrospective, crossed evaluation, on internal initiative, about the clinical records of the pregnant women. Sequence: first evaluation of pregnancies in 1994-95; application of corrective measures in 1996; second evaluation of pregnancies in 1997-98.SettingPrimary care.PatientsAll the pregnancies monitored by our PC team during the periods described.Measurements and main resultsCriteria evaluated: care activities of the programme for monitoring normal pregnancies in Area 10. First evaluation (n = 54): 11.5% overall non-compliance. The criteria with under 80% compliance were: folic acid supplement, counselling, diagnosis of pregnancy diabetes and attendance in the month after delivery. Second evaluation (n = 69): 6.3% overall non-compliance. All activities surpassed 80% compliance except obstetric examination on the first visit, attendance a week after delivery and attendance a month after delivery.ConclusionsAfter introducing certain simple corrective measures, we achieved overall improvement of over 40% and increased compliance in most activities, except for attendance after delivery and obstetric examination on the first visit. We think a continuous cycle of quality improvement needs to be maintained in order to achieve adequate mother-baby care

Hazardous Alcohol Drinking as Predictor of Smoking Relapse (3-, 6-, and 12-Months Follow-Up) by Gender

Diverse studies have found a relation between alcohol consumption and smoking relapse. Few studies have analyzed the relation of smoking relapse with pretreatment alcohol consumption and gender differences. The main purpose of this study is to analyze the influence of alcohol consumption in smoking relapse over 12 months (3-, 6-, and 12-months follow-up) and to determine possible gender differences. The sample included 374 smokers who quit smoking by participating in a psychological smoking cessation treatment. We assessed hazardous pretreatment alcohol drinking (AUDIT), cigarette consumption (FTND; number of cigarettes) and sociodemographic variables. Higher scores on hazardous pretreatment alcohol drinking predict smoking relapse at 3-, 6-, and 12-months after smoking cessation. In males, higher scores on hazardous pretreatment alcohol drinking predict relapse at 6 and at 12 months. In females, higher scores on hazardous pretreatment alcohol drinking predict tobacco relapse at 3 months. Hazardous pretreatment alcohol drinking predicts relapse at all intervals after smoking cessation (3-, 6-, and 12-months follow-up). However, the influence of hazardous pretreatment alcohol drinking on smoking relapse differs as a function of gender, as it is a short-term predictor in women (3 months) and a long-term predictor in men (6 and 12 months)

Cognitive-behavioral treatment with behavioral activation for smokers with depressive symptomatology: Study protocol of a randomized controlled trial

Background: Smoking is an important risk factor for mental health-related problems. Numerous studies have supported a bi-directional association between cigarette smoking and depression. Despite the advances in understanding the comorbidity between both problems, the most effective psychological treatment that simultaneously targets smoking and depressive symptomatology remains unclear. The objective of this study is to assess the effectiveness of a cognitive-behavioral intervention for smoking cessation with components of behavioral activation for managing depressed mood. Method: A single blind, three-arm, superiority randomized controlled trial is proposed. Participants will be smokers over 18years old, who smoke at least 8 cigarettes per day. Participants will be randomized to one of three conditions, using a 2:2:1 allocation ratio: 1) standard cognitive-behavioral smoking cessation treatment; 2) standard cognitive-behavioral smoking cessation treatment plus behavioral activation; or 3) a three-month delayed treatment control group. The primary outcome measures will be biochemically verified point-prevalence abstinence (carbon monoxide in expired air) and significant change from baseline in depressive symptoms to the end of treatment, and at the 3-, 6-, and 12-month follow-up. Discussion: This study aims to assess the efficacy of a cognitive-behavioral intervention with behavioral activation components for smoking cessation and depressive symptoms, compared to a standard cognitive-behavioral intervention to quit smoking. As the relation between depressive symptoms, even at subclinical levels, and quitting smoking difficulties is well known, we expect that such intervention will allow obtaining higher abstinence rates, lower relapse rates, and mood improvement. Trial registration:ClinicalTrials.gov: NCT02844595. Retrospectively registered 19th July, 2016. The study started in January 2016, and the recruitment is ongoing

Cortistain is expressed in a distinct subset of cortical interneurons

Cortistatin is a presumptive neuropeptide that shares 11 of its 14 amino acids with somatostatin. In contrast to somatostatin, administration of cortistatin into the rat brain ventricles specifically enhances slow wave sleep, apparently by antagonizing the effects of acetylcholine on cortical excitability. Here we show that preprocortistatin mRNA is expressed in a subset of GABAergic cells in the cortex and hippocampus that partially overlap with those containing somatostatin. A significant percentage of cortistatin-positive neurons is also positive for parvalbumin. In contrast, no colocalization was found between cortistatin and calretinin, cholecystokinin, or vasoactive intestinal peptide. During development there is a transient increase in cortistatin-expressing cells in the second postnatal week in all cortical areas and in the dentate gyrus. A transient expression of preprocortistatin mRNA in the hilar region at P16 is paralleled by electrophysiological changes in dentate granule cells. Together, these observations suggest mechanisms by which cortistatin may regulate cortical activity

Health-related quality of life among smoking relapsers

Background: Previous studies have shown that smoking is associated with health-related quality of life (HRQoL) impairment. In order to evaluate HRQoL in a sample of Spanish relapsers, a cross-sectional study was conducted. Method: The sample was made up of 775 smokers who had relapsed after a period of abstinence. HRQoL was evaluated using the Euro-Qol questionnaire (EQ-5D); through the descriptive profile, the EQ-5D index and the visual analogue scale (EQ-VAS). Results: Higher nicotine dependence was related to worse HRQL. According to the EQ-VAS, higher daily cigarette consumption and more years smoking were related to worse perceived health. In the EQ-5D those who had quit smoking in the previous year perceived worse health. Mobility and anxiety/ depression are the dimensions affected by smoking. Those who are more nicotine dependent (OR = 2.29) and have been smoking for longer (OR = 4.12) are more likely to have mobility problems; and those who are nicotine dependent (OR = 1.85) and relapsed more than a year ago (OR = 0.63), are more likely to experience anxiety/ depression. Conclusions: Nicotine dependence demonstrated a determining effect on HRQOL deterioration in smokers who have relapsed