Testing the left-handedness of the b \to c transition

We analyse the spin structure of inclusive semileptonic b \to c transitions and the effects of non-standard model couplings on the rates and the spectra. The calculation includes the {\cal O} (\alpha_s) corrections as well as the leading non-perturbative ones.Comment: 15 pages, 3 figure

An S-FSCW Based Multi-Channel Reader System for Beamforming Applications using Surface Acoustic Wave Sensors

Interrogating multiple surface acoustic wave (SAW) sensors located within the same radar beam require techniques to separate the multiple superposing SAW sensor responses. The presented multi-channel reader features four parallel transceiver channels, which are based on the switched frequency-stepped continuous-wave principle and high-speed parallelized baseband electronics. Thus classical beamforming applications including angle of arrival measurement of single SAW tags and the angular separation of multiple SAW sensors are presented and compared to a multiple-input multiple-output (MIMO) approach. Due to the larger virtual array in the MIMO approach a larger aperture can be synthesized, which leads to significantly better angular separation results. The level analysis for the given system is verified by baseband-power measurements at different readout distances, considering the hardware parameters as well as the free-space propagation aspects. Finally measurements assess the maximum interrogation distance for the system

Fluxes of Nitrogen, Phosphorus, and Dissolved Organic Carbon in the inflow of the Lehnmühle reservoir (Saxony) as compared to streams draining three main land-use types in the catchment

The aim of this study was to assess the impact of land-use on inputs of nitrogen, phosphorus, and DOC into the inflow of the Lehnmühle reservoir (drinking water supply). Land-use in the study area is dominated by forest, with smaller proportions of grassland and crops. Water quality was analyzed for the hydrological years 2010 and 2011 at the outlets of three small catchments with homogenous land-use (crops, grassland and forest) and at the outlet of the watershed. The highest nitrogen and phosphorus concentrations were observed in the streams draining the agricultural areas, and the lowest concentrations were found in the forest catchment. The DOC concentration was highest at the outlet of the watershed whereas the concentrations in the small homogeneous catchments were lower. The information collected about the land-use dependent matter exports in these study areas will be used for climate change impact modeling with the Soil and Water Assessment Tool

Generation of an Object-based Nowcasting Ensemble

Presentación realizada en la 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019

Combination of object-based probabilistic nowcasting and NWP ensemble

Póster presentado en: 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019

Development of a probabilistic precipitation-nowcastingapproach at DWD

Presentación realizada en la 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019

Recording problems and diagnoses in clinical care: developing guidance for healthcare professionals and system designers

BACKGROUND: Accurate recording of problems and diagnoses in health records is key to safe and effective patient care, yet it is often done poorly. Electronic health record systems vary in their functionality and ease of use, and are not optimally designed for easy recording and sharing of clinical information. There is a lack of professional consensus and guidance on how problems and diagnoses should be recorded. METHODS: The Professional Record Standards Body commissioned work led by the Royal College of Physicians Health Informatics Unit to carry out a literature review, draft guidance, carry out an online consultation and round table discussion, and produce a report including recommendations for systems. A patient workshop was held to explore patient preferences for mechanisms for sharing diagnosis information between primary and secondary care. RESULTS: Consensus was reached among medical specialties on key elements of diagnosis recording, and draft guidance was produced ready for piloting in a variety of care settings. Patients were keen for better ways for diagnosis information to be shared. DISCUSSION: Improving the recording of diagnoses and problems will require a major effort of which the new guidance is only a part. The guidance needs to be embedded in training, and clinical systems need to have improved, standardised functionality. Front-line clinicians, specialist societies, clinical informaticians and patients need to be engaged in developing information models for diagnoses to support care and research, accessible via user-friendly interfaces

PKB/SGK-resistant GSK-3 signaling following unilateral ureteral obstruction

Background/Aims: Renal tissue fibrosis contributes to the development of end-stage renal disease. Causes for renal tissue fibrosis include obstructive nephropathy. The development of renal fibrosis following unilateral ureteral obstruction (UUO) is blunted in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1. Similar to Akt isoforms, SGK1 phosphorylates and thus inactivates glycogen synthase kinase GSK-3. The present study explored whether PKB/SGK-dependent phoshorylation of GSK-3α/β impacts on pro-fibrotic signaling following UUO. Methods: UUO was induced in mice carrying a PKB/SGK-resistant GSK-3α/β (gsk-3KI) and corresponding wild-type mice (gsk-3WT). Three days after the obstructive injury, expression of fibrosis markers in kidney tissues was analyzed by quantitative RT-PCR and western blotting. Results: GSK-3α and GSK-3β phosphorylation was absent in both, the non-obstructed and the obstructed kidney tissues from gsk-3KI mice but was increased by UUO in kidney tissues from gsk-3WT mice. Expression of α-smooth muscle actin, type I collagen and type III collagen in the non-obstructed kidney tissues was not significantly different between gsk-3KI mice and gsk-3WT mice but was significantly less increased in the obstructed kidney tissues from gsk-3KI mice than from gsk-3WT mice. After UUO treatment, renal β-catenin protein abundance and renal expression of the β-catenin sensitive genes: c-Myc, Dkk1, Twist and Lef1 were again significantly less increased in kidney tissues from gsk-3KI mice than from gsk-3WT mice. Conclusions: PKB/SGK-dependent phosphorylation of glycogen synthase kinase GSK-3 contributes to the pro-fibrotic signaling leading to renal tissue fibrosis in obstructive nephropathy