1,133 research outputs found

    Echocardiographic study of myocardial performance after exercise in type I diabetes mellitus

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    Multi-Objective Hybrid Optimal Control for Multiple-Flyby Low-Thrust Mission Design

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    Preliminary design of low-thrust interplanetary missions is a highly complex process. The mission designer must choose discrete parameters such as the number of flybys, the bodies at which those flybys are performed, and in some cases the final destination. In addition, a time-history of control variables must be chosen that defines the trajectory. There are often many thousands, if not millions, of possible trajectories to be evaluated. The customer who commissions a trajectory design is not usually interested in a point solution, but rather the exploration of the trade space of trajectories between several different objective functions. This can be a very expensive process in terms of the number of human analyst hours required. An automated approach is therefore very desirable. This work presents such an approach by posing the mission design problem as a multi-objective hybrid optimal control problem. The method is demonstrated on a hypothetical mission to the main asteroid belt

    UV-curable glassy material for the manufacture of bulk and nano-structured elements

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    An ultra violet (UV) -cured glassy material with less than 30% organic residues was fabricated by the fast sol-gel method. The material presents high thermal stability, good optical quality and high adhesive strength. It is suitable for optical bonding and, for manufacture of optical elements and micro-structured optical devices. Either soft-lithography or photo-lithography may be used for manufacture of the material while its curing can be thermal (few hours) or UV (few seconds). In this work we present the technology to fabricate optical elements at scales spanning the sub-micron to centimeter range. This technology enables mass-production of optical elements at low cost

    Frontal Hypoactivation During a Working Memory Task in Children With 22q11 Deletion Syndrome

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    Impairments in executive function, such as working memory, are almost universal in children with chromosome 22q11.2 deletion syndrome. Delineating the neural underpinnings of these functions would enhance understanding of these impairments. In this study, children and adolescents with 22q11 deletion syndrome were compared with healthy control participants in an fMRI study of working memory. When the 2-back condition was contrasted with the 1-back and 0-back conditions, the participants with 22q11 deletion syndrome showed lower activation in several brain areas involved in working memory—notably dorsolateral prefrontal cortex, anterior cingulate, and precuneus. This hypoactivation may be due to reduced gray matter volumes or white matter connectivity in frontal and parietal regions, differences that have previously been documented in children with 22q11 deletion syndrome. Understanding differences in brain function will provide a foundation for future interventions to address the wide range of neurodevelopmental deficits observed in 22q11 deletion syndrome

    Order of the phase transition in models of DNA thermal denaturation

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    We examine the behavior of a model which describes the melting of double-stranded DNA chains. The model, with displacement-dependent stiffness constants and a Morse on-site potential, is analyzed numerically; depending on the stiffness parameter, it is shown to have either (i) a second-order transition with "nu_perpendicular" = - beta = 1, "nu_parallel" = gamma/2 = 2 (characteristic of short range attractive part of the Morse potential) or (ii) a first-order transition with finite melting entropy, discontinuous fraction of bound pairs, divergent correlation lengths, and critical exponents "nu_perpendicular" = - beta = 1/2, "nu_parallel" = gamma/2 = 1.Comment: 4 pages of Latex, including 4 Postscript figures. To be published in Phys. Rev. Let

    Precautionary Regulation in Europe and the United States: A Quantitative Comparison

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    Much attention has been addressed to the question of whether Europe or the United States adopts a more precautionary stance to the regulation of potential environmental, health, and safety risks. Some commentators suggest that Europe is more risk-averse and precautionary, whereas the US is seen as more risk-taking and optimistic about the prospects for new technology. Others suggest that the US is more precautionary because its regulatory process is more legalistic and adversarial, while Europe is more lax and corporatist in its regulations. The flip-flop hypothesis claims that the US was more precautionary than Europe in the 1970s and early 1980s, and that Europe has become more precautionary since then. We examine the levels and trends in regulation of environmental, health, and safety risks since 1970. Unlike previous research, which has studied only a small set of prominent cases selected non-randomly, we develop a comprehensive list of almost 3,000 risks and code the relative stringency of regulation in Europe and the US for each of 100 risks randomly selected from that list for each year from 1970 through 2004. Our results suggest that: (a) averaging over risks, there is no significant difference in relative precaution over the period, (b) weakly consistent with the flip-flop hypothesis, there is some evidence of a modest shift toward greater relative precaution of European regulation since about 1990, although (c) there is a diversity of trends across risks, of which the most common is no change in relative precaution (including cases where Europe and the US are equally precautionary and where Europe or the US has been consistently more precautionary). The overall finding is of a mixed and diverse pattern of relative transatlantic precaution over the period

    Sex Differences in Absence from Work: A Reinterpretation

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    Sex differences in absence from work were investigated for parents and nonparents during a period of 11 months. Personnel records showed sex differences only among working parents, with mothers taking significantly more sick leave than fathers (p < .05). By using self-reports obtained under protection of anonymity it was found that in the parent group both sexes reported absences necessitated by child care as personal illness, but significantly more women than men were absent from work for such activities (p < .01). Results from this study shed light on the statement that “women are more likely than men to be absent from work because of illness” (U.S. Department of Labor Bureau Bulletin, 1977); child care, rather than personal illness, appears to be the major variable that mediates sex differences in absence from work.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

    Refining Lucy Mission Delta-V During Spacecraft Design Using Trajectory Optimization Within High-Fidelity Monte Carlo Maneuver Analysis

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    Recent advances linking medium-fidelity trajectory optimization and high-fidelity trajectory propagation/maneuver design software with Monte Carlo maneuver analysis and parallel processing enabled realistic statistical delta-V estimation well before launch. Completing this high-confidence, refined statistical maneuver analysis early enabled release of excess delta-V margin for increased dry mass margin for the Lucy Jupiter Trojan flyby mission. By 3.3 years before launch, 16 of 34 TCMs had 1000 re-optimized trajectory design samples, yielding tens of m/s lower 99%-probability delta-V versus targeting maneuvers to one optimal trajectory. One year later, 1000 re-optimized samples of all deterministic maneuvers and subsequent flybys further lowered estimated delta-V
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