930 research outputs found
Development of optimum clamp combinations for strap-down inertial measuring units with field replaceable sensors
Optimum clamp combinations for strap down inertial measuring units with field replaceable sensor
Inverse Scattering at a Fixed Quasi-Energy for Potentials Periodic in Time
We prove that the scattering matrix at a fixed quasi--energy determines
uniquely a time--periodic potential that decays exponentially at infinity. We
consider potentials that for each fixed time belong to in space. The
exponent 3/2 is critical for the singularities of the potential in space. For
this singular class of potentials the result is new even in the
time--independent case, where it was only known for bounded exponentially
decreasing potentials.Comment: In this revised version I give a more detailed motivation of the
class of potentials that I consider and I have corrected some typo
The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
We have previously shown that exon 1 of the huntingtin gene does not always splice to exon 2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein. The level of this read-through product is proportional to CAG repeat length and is present in all knock-in mouse models of Huntington’s disease (HD) with CAG lengths of 50 and above and in the YAC128 and BACHD mouse models, both of which express a copy of the human HTT gene. We have now developed specific protocols for the quantitative analysis of the transcript levels of HTTexon1 in human tissue and applied these to a series of fibroblast lines and post-mortem brain samples from individuals with either adult-onset or juvenile-onset HD. We found that the HTTexon1 mRNA is present in fibroblasts from juvenile HD patients and can also be readily detected in the sensory motor cortex, hippocampus and cerebellum of post-mortem brains from HD individuals, particularly in those with early onset disease. This finding will have important implications for strategies to lower mutant HTT levels in patients and the design of future therapeutics
The SKA Particle Array Prototype: The First Particle Detector at the Murchison Radio-astronomy Observatory
We report on the design, deployment, and first results from a scintillation
detector deployed at the Murchison Radio-astronomy Observatory (MRO). The
detector is a prototype for a larger array -- the Square Kilometre Array
Particle Array (SKAPA) -- planned to allow the radio-detection of cosmic rays
with the Murchison Widefield Array and the low-frequency component of the
Square Kilometre Array. The prototype design has been driven by stringent
limits on radio emissions at the MRO, and to ensure survivability in a desert
environment. Using data taken from Nov.\ 2018 to Feb.\ 2019, we characterize
the detector response while accounting for the effects of temperature
fluctuations, and calibrate the sensitivity of the prototype detector to
through-going muons. This verifies the feasibility of cosmic ray detection at
the MRO. We then estimate the required parameters of a planned array of eight
such detectors to be used to trigger radio observations by the Murchison
Widefield Array.Comment: 17 pages, 14 figures, 3 table
Time Dependent Floquet Theory and Absence of an Adiabatic Limit
Quantum systems subject to time periodic fields of finite amplitude, lambda,
have conventionally been handled either by low order perturbation theory, for
lambda not too large, or by exact diagonalization within a finite basis of N
states. An adiabatic limit, as lambda is switched on arbitrarily slowly, has
been assumed. But the validity of these procedures seems questionable in view
of the fact that, as N goes to infinity, the quasienergy spectrum becomes
dense, and numerical calculations show an increasing number of weakly avoided
crossings (related in perturbation theory to high order resonances). This paper
deals with the highly non-trivial behavior of the solutions in this limit. The
Floquet states, and the associated quasienergies, become highly irregular
functions of the amplitude, lambda. The mathematical radii of convergence of
perturbation theory in lambda approach zero. There is no adiabatic limit of the
wave functions when lambda is turned on arbitrarily slowly. However, the
quasienergy becomes independent of time in this limit. We introduce a
modification of the adiabatic theorem. We explain why, in spite of the
pervasive pathologies of the Floquet states in the limit N goes to infinity,
the conventional approaches are appropriate in almost all physically
interesting situations.Comment: 13 pages, Latex, plus 2 Postscript figure
Excitation of Small Quantum Systems by High-Frequency Fields
The excitation by a high frequency field of multi--level quantum systems with
a slowly varying density of states is investigated. A general approach to study
such systems is presented. The Floquet eigenstates are characterized on several
energy scales. On a small scale, sharp universal quasi--resonances are found,
whose shape is independent of the field parameters and the details of the
system. On a larger scale an effective tight--binding equation is constructed
for the amplitudes of these quasi--resonances. This equation is non--universal;
two classes of examples are discussed in detail.Comment: 4 pages, revtex, no figure
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Spatial Distribution of Plant-Parasitic Nematodes in Semi-Arid Vitis vinifera Vineyards in Washington
The most commonly encountered plant-parasitic nematodes in eastern Washington Vitis vinifera vineyards are Meloidogyne hapla, Mesocriconema xenoplax, Pratylenchus spp., Xiphinema americanum, and Paratylenchus sp.; however, little is known about their distribution in the soil profile. The vertical and horizontal spatial distribution of plant-parasitic nematodes was determined in two Washington V. vinifera vineyards. Others variables measured in these vineyards included soil moisture content, fine root biomass, and root colonization by arbuscular mycorhizal fungi (AMF). Meloidogyne hapla and M. xenoplax were aggregated under irrigation emitters within the vine row and decreased with soil depth. Conversely, Pratylenchus spp. populations were primarily concentrated in vineyard alleyways and decreased with depth. Paratylenchus sp. and X. americanum were randomly distributed within the vineyards. Soil water content played a dominant role in the distribution of fine roots and plant-parasitic nematodes. Colonization of fine roots by AMF decreased directly under irrigation emitters; in addition, galled roots had lower levels of AMF colonization compared with healthy roots. These findings will help facilitate sampling and management decisions for plant-parasitic nematodes in Washington semi-arid vineyards.This is the publisher’s final pdf. The published article is copyrighted by the Society of Nematologists and can be found at: http://journals.fcla.edu/jon/indexKeywords: Spatial distribution, Plant-parasitic nematodes, Management, Washington, Vitis vinifera, Semi-arid, Arbuscular mycorrhizal fungi colonizatio
It's Harder to Splash on Soft Solids
Droplets splash when they impact dry, flat substrates above a critical
velocity that depends on parameters such as droplet size, viscosity and air
pressure. By imaging ethanol drops impacting silicone gels of different
stiffnesses we show that substrate stiffness also affects the splashing
threshold. Splashing is reduced or even eliminated: droplets on the softest
substrates need over 70\% more kinetic energy to splash than they do on rigid
substrates. We show that this is due to energy losses caused by deformations of
soft substrates during the first few microseconds of impact. We find that
solids with Young's moduli kPa reduce splashing, in agreement
with simple scaling arguments. Thus materials like soft gels and elastomers can
be used as simple coatings for effective splash prevention. Soft substrates
also serve as a useful system for testing splash-formation theories and
sheet-ejection mechanisms, as they allow the characteristics of ejection sheets
to be controlled independently of the bulk impact dynamics of droplets.Comment: 5 pages, 4 figure
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