Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction - (TOPCARE-AMI)

Background - Experimental studies suggest that transplantation of blood-derived or bone marrow–derived progenitor cells beneficially affects postinfarction remodeling. The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown

Achievements in CTF3 and Commissioning status

The aim of the latest CLIC test facility CTF3, built at CERN by an international collaboration, is to prove the main feasibility issues of the CLIC two-beam acceleration technology. Several of the main goals have been already achieved in the past years, like the full-loading linac operation mode and the delay loop principle. During 2008 also the combiner ring concept has been experimentally proven and the recombined beam has been used to generate the RF power. In parallel in the fall of the year also the probe beam line commissioning had started

Experimental Studies on Drive Beam Generation in CTF3

The objective of the CLIC Test Facility CTF3, built at CERN by an international collaboration, is to demonstrate the main feasibility issues of the CLIC two-beam technology by 2010. CTF3 consists of a 150 MeV electron linac followed by a 42 m long delay loop, an 84 m combiner ring and a two-beam test area. One keyissue studied in CTF3 is the efficient generation of a very high current drive beam, used in CLIC as the power source for the acceleration of the main beam to multi-TeV energies. The beam current is first doubled in the delay loop and then multiplied again by a factor four in the combiner ring by interleaving bunches using transverse deflecting RF cavities. The combiner ring and the connecting transfer line have been installed and put into operation in 2007. In this paper we give the status of the commissioning, illustrate the beam optics measurements, discuss the main issues and present the results of the combination tests

High Power Test on an x-Band Slotted-Iris Accelerator Structure at NLCTA

The CLIC study group at CERN has built two X-band HDS (Hybrid Damped Structure) accelerating structures for high-power testing in NLCTA at SLAC. These accelerating structures are novel with respect to their rf-design and their fabrication technique. The eleven-cell constant impedance structures, one made out of copper and one out of molybdenum, are assembled from clamped high-speed milled quadrants. They feature the same heavy higher-order-mode damping as nominal CLIC structures achieved by slotted irises and radial damping waveguides for each cell. The X-band accelerators are exactly scaled versions of structures tested at 30 GHz in the CLIC test facility, CTF3. The results of the X-band tests are presented and compared to those at 30 GHz to determine frequency scaling, and are compared to the extensive copper data from the NLC structure development program to determine material dependence and make a basic validation of the HDS design. INTRODUCTIO

High-Power Testing of X-Band CLIC Power Generating Structures

A fundamental element of the CLIC concept is two-beam acceleration, where rf power is extracted from a high-current and low-energy beam in order to accelerate the low-current main beam to high energy. The power extraction occurs in special Xband Power Extraction and Transfer Structures (PETS). The structures are large aperture, high-group velocity and overmoded periodic structures. Following the substantial changes of the CLIC baseline parameters in 2006, the PETS design has been thoroughly updated along with the fabrication methods and corresponding rf components. Two PETS prototypes have been fabricated and high power tested. Test results and future plans are presented

Laser Wire Scanner Development on CTF II

A laser wire scanner is under development at CERN in the framework of the Compact Linear Collider study (CLIC). A first test has been carried out at the CLIC Test Facility II (CTF II) with the aim of developing a beam profile monitor for a low energy, high charge electron beam. In our set-up a 2.5 mJ, 1047 nm, 4 ps laser pulse interacts with a 50 MeV, 1 nC, 4 ps electron bunch. A scintillator detects up to 600 X-ray photons, with an average energy of 17 keV. In the present status of the experiment Thomson photons have been observed, but the signal to noise ratio is however still too low for an accurate profile measurement

Time resolved spectrometry on the CLIC Test Facility 3

The high charge (>6ìC) electron beam produced in the CLIC Test Facility 3 (CTF3) is accelerated in fully beam loaded cavities. To be able to measure the resulting strong transient effects, the time evolution of the beam energy and its energy spread must be determined with at least 50MHz bandwidth. Three spectrometer lines are installed along the linac in order to control and tune the beam. The electrons are deflected by dipole magnets onto Optical Transition Radiation (OTR) screens which are observed by CCD cameras. The measured horizontal beam size is then directly related to the energy spread. In order to provide time-resolved energy spectra, a fraction of the OTR photons is sent onto a multi-channel photomultiplier. The overall setup is described, special focus is given to the design of the OTR screen with its synchrotron radiation shielding. The performance of the time-resolved measurements are discussed in detail. Finally, the limitations of the system, mainly due to radiation problems are discussed

Commissioning Status of the CTF3 Delay Loop

The CLIC Test Facility CTF3, built at CERN by an international collaboration, aims at demonstrating the linear collider by 2010. In particular, one of the main goals is to study the generation of high-current electron pulses by interleaving bunch trains in delay lines and rings using transverse RF deflectors. This will be done in the 42 m long delay loop, built under the responsibility of INFN/LNF, and the 84 m long combiner ring that will follow it. The delay loop installation was completed and its commissioning started at the end of 2005. In this paper the commissioning results are presented, including the first tests of beam recombination

Beam Dynamics and First Operation of the Sub-Harmonic Bunching System in the CTF3 Injector

The CLIC Test Facility 3 (CTF3), built at CERN by an international collaboration, aims at demonstrating the feasibility of the CLIC scheme by 2010. The CTF3 drive beam generation scheme relies on the use of a fast phase switch of a sub-harmonic bunching system in order to phase-code the bunches. The amount of charge in unwanted satellite bunches is an important quantity, which must be minimized. Beam dynamic simulations have been used to study the problem, showing the limitation of the present CTF3 design and the gain of potential upgrades. In this paper the results are discussed and compared with beam measurements taken during the first operation of the system