3,037 research outputs found
P53 tumour-suppressor gene mutations are mainly localised on exon 7 in human primary and metastatic prostate cancer.
Mutations in the p53 tumour-suppressor gene are among the most common genetic alterations in human cancers. In the present study we analysed the mutations in the p53 tumor-suppressor gene in 25 primary and 20 metastatic human prostate cancer specimens. DNA extracted from the paraffin-embedded sections was amplified by hot-start polymerase chain reaction, and p53 gene mutations in the conserved mid-region (exons 4-9) were examined using single-strand conformation polymorphism (SSCP) analysis and immunohistochemistry. In the present study, we used a novel hot-start PCR-SSCP technique using DNA Taq polymerase antibody, which eliminates primer-dimers and non-specific products. Because of this new technique, the results of PCR-SSCP showed very high resolution. Polymerase chain reaction products were sequenced directly for point mutations for the p53 gene. Mutations were found in 2 out of 25 primary prostate cancers (8%) and 4 out of 20 metastatic cancers (20%). Mutations were observed exclusively in exon 7 and not in exons 4, 5, 6, 8 or 9. Nuclear accumulation of p53 protein, determined by immunohistochemistry, correlated with the degree of metastasis in prostatic cancer
Symmetric-Asymmetric transition in mixtures of Bose-Einstein condensates
We propose a new kind of quantum phase transition in phase separated mixtures
of Bose-Einstein condensates. In this transition, the distribution of the two
components changes from a symmetric to an asymmetric shape. We discuss the
nature of the phase transition, the role of interface tension and the phase
diagram. The symmetric to asymmetric transition is the simplest quantum phase
transition that one can imagine. Careful study of this problem should provide
us new insight into this burgeoning field of discovery.Comment: 6 pages, 3 eps figure
Co-ordination between Rashba spin-orbital interaction and space charge effect and enhanced spin injection into semiconductors
We consider the effect of the Rashba spin-orbital interaction and space
charge in a ferromagnet-insulator/semiconductor/insulator-ferromagnet junction
where the spin current is severely affected by the doping, band structure and
charge screening in the semiconductor. In diffusion region, if the the
resistance of the tunneling barriers is comparable to the semiconductor
resistance, the magnetoresistance of this junction can be greatly enhanced
under appropriate doping by the co-ordination between the Rashba effect and
screened Coulomb interaction in the nonequilibrium transport processes within
Hartree approximation.Comment: 4 pages, 3 figure
Phase separation and vortex states in binary mixture of Bose-Einstein condensates in the trapping potentials with displaced centers
The system of two simultaneously trapped codensates consisting of
atoms in two different hyperfine states is investigated theoretically in the
case when the minima of the trapping potentials are displaced with respect to
each other. It is shown that the small shift of the minima of the trapping
potentials leads to the considerable displacement of the centers of mass of the
condensates, in agreement with the experiment. It is also shown that the
critical angular velocities of the vortex states of the system drastically
depend on the shift and the relative number of particles in the condensates,
and there is a possibility to exchange the vortex states between condensates by
shifting the centers of the trapping potentials.Comment: 4 pages, 2 figure
Density Modulations and Addition Spectra of Interacting Electrons in Disordered Quantum Dots
We analyse the ground state of spinless fermions on a lattice in a weakly
disordered potential, interacting via a nearest neighbour interaction, by
applying the self-consistent Hartree-Fock approximation. We find that charge
density modulations emerge progressively when r_s >1, even away from
half-filling, with only short-range density correlations. Classical geometry
dependent "magic numbers" can show up in the addition spectrum which are
remarkably robust against quantum fluctuations and disorder averaging.Comment: 4 pages, 3 eps figure
Reorientation transition of ultrathin ferromagnetic films
We demonstrate that the reorientation transition from out-of-plane to
in-plane magnetization with decreasing temperature as observed experimentally
in Ni-films on Cu(001) can be explained on a microscopic basis. Using a
combination of mean field theory and perturbation theory, we derive an analytic
expression for the temperature dependent anisotropy. The reduced magnetization
in the film surface at finite temperatures plays a crucial role for this
transition as with increasing temperature the influence of the uniaxial
anisotropies is reduced at the surface and is enhanced inside the film.Comment: 4 pages(RevTeX), 3 figures (EPS
Psychometric Validation of Four-Item Exercise Identity and Healthy-Eater Identity Scales and Applications in Weight Loss Maintenance
Background: Identifying as someone who engages in health promoting behaviors like healthy eating and exercising may be associated with sustained engagement in those behaviors, but reliable and valid instruments are needed to improve the rigor of this research. Two studies were conducted to (1) examine the psychometric properties of a four-item exerciser identity measure (4-EI) and an adapted healthy-eater identity measure (4-HEI) and (2) examine differences in identity strengths across categories of weight loss success. Methods: Data from 1,709 community dwelling adults in the International Weight Control Registry (IWCR) were used. A random half of the sample was used to assess the proposed unidimensional factor structure of the 4-EI and 4-HEI and examine convergent and discriminant validity using Spearman rank-order correlations. One-way ANOVA was used in the other random half of the sample to compare 4-EI and 4-HEI scores (-3 to + 3) across three self-defined weight loss categories (‘Successful’, ‘Regain’, and ‘Unsuccessful’) and those maintaining ≥ 5% weight loss for > 1 year vs. not. Results: Results support the unidimensional factor structure with all four items (eigenvalue scores > 2.89) as well as convergent and discriminant validity for both measures. Exercise identity was strongly correlated with self-reported physical activity (r (735) = 0.52, p <.001) and measures of autonomous motivation. Healthy eating identity was moderately correlated with cognitive restraint in eating (r (744) = 0.42, p <.001) and other measures predictive of eating behavior. 4-EI and 4-HEI are stronger in Successful (4-EI: M = 0.90, SD = 1.77; 4-HEI: M = 1.56 SD = 1.37) vs. Regain (4-EI: M=-0.18, SD = 1.68; 4-HEI: M =.57, SD = 1.48) and Unsuccessful (4-EI:M=-0.28, SD = 1.62; 4-HEI: M = 0.51, SD = 1.33) and those maintaining ≥ 5% weight loss (4-EI:M = 0.47, SD = 1.78; 4-HEI: M = 1.13, SD = 1.49) vs. not (4-EI:M=-0.27, SD = 1.66; 4-HEI: M = 0.53, SD = 1.47), p’s < 0.001. Conclusions: The 4-EI and 4-HEI have acceptable psychometric properties and can advance understanding of the role of identity in exercise and dietary behaviors and weight loss maintenance. Trial registration: The parent observational study, International Weight Control Registry (IWCR), for these sub-studies is registered in ClinicalTrials.gov (NCT04907396).</p
The missing group? Situating transnational contacts in defamilisation research
Defamilisation research is increasingly seen as an important component of studies of welfare and social work. It is concerned with people’s vulnerability to defamilisation risks, which are caused by insufficient opportunities for people to choose whether and how they participate in the family. Despite an increasing emphasis on defamilisation research, there has been insufficient attention given to how studies of transnational contacts contribute to defamilisation research. This article argues for the need to expand the scope of defamilisation research to incorporate the concept of ‘transnational contact-led strategies’ using evidence from focus groups with Chinese older people in the United Kingdom
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