Reservoir Simulation on the Cerro Prieto Geothermal Field: A Continuing Study

The Cerro Prieto geothermal field is a liquid-dominated geothermal reservoir of complex geological and hydrological structure. It is located at the southern end of the Salton-Mexicali trough which includes other geothermal anomalies as Heber and East Mesa. Although in 1973, the initial power plant installed capacity was 75 MW of electrical power, this amount increased to 180 MW in 1981 as field development continued. It is expected to have a generating capacity of 620 MW by the end of 1985, when two new plants will be completely in operation. Questions about field deliverability, reservoir life and ultimate recovery related to planned installations are being presently asked. Numerical modeling studies can give very valuable answers to these questions, even at the early stages in the development of a field. An effort to simulate the Cerro Prieto geothermal reservoir has been undergoing for almost two years. A joint project among Comision Federal de Electricidad (CFE), Instituto de Investigaciones Electricas (IIE) and Intercomp of Houstin, Texas, was created to perform reservoir engineering and simulation studies on this field. The final project objective is tosimulate the behavior of the old field region when production from additional wells located in the undeveloped field zones will be used for feeding the new power plants

Questione: Se il patto di famiglia sia un contratto bilaterale fra disponente e assegnatario oppure un contratto plurilaterale per la cui conclusione sono necessari i consensi di disponente, assegnatario e legittimari non assegnatari

NMDA and AMPA receptors are thought to be responsible for Ca++ influx during glutamate-induced excitotoxicity and, therefore, hippocampal neuronal death. We assessed whether excitotoxicity induced by neonatal treatment with monosodium glutamate in rats at postnatal age of 1, 3, 5, and 7 modifies the hippocampal expression of the NMDAR subunit NR1 and the AMPAR subunits GluR1/GluR2 at postnatal days 8, 10, 12, and 14. We also assessed the involvement of MAPK signaling by using the p38 inhibitor SB203580. Our results showed that monosodium glutamate induces neuronal death and alters the expression of the subunits evaluated in the hippocampus at all ages studied, which could be prevented by SB203580 treatment. Furthermore, expression of the NRSF gene silencing factor also increased in response to excitotoxicity, suggesting a relationship in suppressing GluR2-expression, which was regulated by the p38-MAPK pathway inhibitor SB203580. This result suggests that selectively blocking the pro-death signaling pathway may reduce neuronal death in some neurodegenerative diseases in which these neurotoxic processes are present and produce major clinical benefits in the treatment of these pathologies. © 2014, Springer Science+Business Media New York

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

Background Rosiglitazone is a thiazolidinedione that reduces insulin resistance and might preserve insulin secretion. The aim of this study was to assess prospectively the drugs ability to prevent type 2 diabetes in individuals at high risk of developing the condition