30 research outputs found
The role of peptides in bone healing and regeneration: A systematic review
Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration. Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study. Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited. Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge
Biokompatibilität einer Hydroxylapatit (HA) - Gentamicin Beschichtung für zementfreie Endoprothesen - Ein Kaninchenmodell -
Vergleich der Knochenneubildung und Implantatintegration von HA-RGD-Beschichtung mit reiner HA-Beschichtung für zementfreie Endoprothesen - Eine 12-Wochen-Studie am Kaninchen
Gentamicin-Hydroxylapatit(HA) und Gentamicin-RGD-HA-Beschichtung für zementfreie Endoprothesen - Verbesserung der Infektionsprophylaxe auf Kosten der Implantatintegration?
HA-RGD-Gentamicin-Beschichtung für zementfreie Endoprothesen zeigt gute Biokompatibilität und gutes Knocheneinwachsverhalten - eine 12-Wochen-Studie am Kaninchen
Eine gesundheitsökonomische Analyse für westeuropäische Gesundheitssysteme für den Einsatz von BMP-2 bei offenen Tibiafrakturen
BMP-2 führt beim Einsatz bei ventralen Spondylodesen zu Kosteneinsparungen für das Gesundheitssystem - Ein gesundheitsökonomisches Modell für den Einsatz von BMP-2 in der Wirbelsäulenchirurgie
Variation in training regimens in professional showjumping yards
REASONS FOR PERFORMING STUDY: Training regimens of showjumping horses under field conditions are largely undocumented.
OBJECTIVES: The aims of this study were to quantify and compare training regimens used in professional-level showjumping yards, with respect to time exercised and type of activity.
STUDY DESIGN: Prospective cohort study.
METHODS: A prospective 6-month cohort study of showjumping horses in 4 European countries (The Netherlands, Sweden, Switzerland, Great Britain) was designed to analyse training and health data, in yards with several horses in training and riders competing at professional level. Riders documented the daily frequency and duration of all physical activities of the horses. Variation in training routines were compared between riders, location and time. Mixed-models analysis was used to examine factors associated with total time exercised and time spent in flatwork.
RESULTS: In 4 countries, the 31 participating riders trained 263 European Warmbloods. The total days at risk (e.g. days in which the horses were considered fit for exercise) was 39,262. Mean time spent in daily exercise, including ridden work, lungeing and treadmill exercise, varied between riders from 19-52 min/day at risk. There was considerable variation in activities and level of heavy work and light exercise, i.e. turnout. Total time exercised and time spent in flatwork differed with month, country and proportion of days lost to training. Low variation of activities was associated with decreased total time trained and increased time spent in flatwork.
CONCLUSIONS: Riders at this elite professional level of showjumping used training regimens that vary substantially in time spent training and other physical activities and showjumping horses are challenged differently during training despite competing at the same level. Whether all training regimens prepare the horses equally for the demands of competition remains to be determined