(Z)-4-{1-[(2-Hy­droxy­ethyl)­amino]­ethyl­idene}-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one

In the title compound C14H17N3O2, the dihedral angle between the rings is 16.68 (13)°. Although the compound crystallizes in the keto form, the possibility of keto-enamine–enol-imine tautomerism is explained by a strong intra­molecular N—H⋯O hydrogen bond

Identification & differentiation of Mycobacterium avium & M. intracellulare by PCR- RFLP assay using the groES gene

Background & objectives: We report a new polymerase chain reaction (PCR) – restriction fragment length polymorphism (RFLP) assay using mycobacterial groES as a target to identify Mycobacterium avium and M. intracellulare in clinical samples. Methods: The assay was standardized using M. avium and M. intracellulare standard strains obtained from ATCC and was tested with 45 M. avium-M. intracellulare complex (MAC) clinical isolates (Of which 31 were from HIV+ individuals). The standard and clinical strains were typed with HPLC based mycolic acid fingerprinting. Results: Three polymorphisms (BamHI, BstNI and HgaI) were identified for inter-species differentiation among standard strains; of which, only HgaI was found to be useful in clinical isolates. Of the 45 isolates, 25 were M. avium and 20 were M. intracelluare. MAC isolates, which could not be differentiated by HPLC analysis, were also typed by this method. Interpretation & conclusions: The use of mycobacterial groES as a PCR-RFLP target for M. avium and M. intracellulare is a simple and rapid method that can complement HPLC in their differentiation

Effect of Filarial Infection on Serum Inflammatory and Atherogenic Biomarkers in Coronary Artery Disease (CURES-121)

Helminth infections can potentially confer protection against metabolic disorders, possibly through immunomodulation. In this study, the baseline prevalence of lymphatic filariasis (LF) among subjects without (N = 236) and with (N = 217) coronary artery disease (CAD) was examined as part of the Chennai Urban Rural Epidemiological Study (CURES). The prevalence of LF was not significantly different between CAD− and CAD+ subjects. The LF antigen load and antibody levels indicated comparable levels of infection and exposure between the groups. Within the CAD group, LF+ and LF− subjects had no significant difference in the intimal medial thickness and high-sensitivity C-reactive protein values. However, LF infection was associated with augmented levels of tumor necrosis factor-α and interleukin-6 among CAD+ subjects. The LF infection had no effect on serum adipocytokine profile. In conclusion, unlike type-2 diabetes, there is no association between the prevalence of LF and CAD and also no evidence of protective immunomodulation of LF infection on CAD in the Asian Indian population

An Analytic Report on Ontology Based Search Engine

Abstract : Ontology based search engine is a tool that helps you in retrieving required information from the web by only considering the logical denotation of the submitted query. The semantic based search engines are the annotated form of the ontology based search engines. The paper identifies various methods involved in determination and identification of various ontology based search engines. The search engines types discussed in the paper is broadly classified into keyword based search engine and semantic based search engine. Majorly the efficiency of both the kind of search engines is taken into consideration here. In paper [1] the fuzzy ontology modelling is the main feature. This method is done to find the exact meaning and the relationship between the queries submitted by the user. The fuzzy logic that has been implemented will provide the accurate meaning between them in collaborative sequence. In paper [2] there has been a comparison made between keyword and semantic based search engines. In paper [3] for identifying the relationship, the concept is split into two. They are content concept and location concept. Here for the location concept, the external GPS method is used. In paper [4] multi crawler concepts are used. In this paper, a survey is presented about ontology based search engines and the need for the user's migration to it

Design and Optimization of a Duct in Different Working Conditions for Circular and Elliptical Section

The objective is to evaluate and compare the computational fluid dynamic analysis of duct under three types of working conditions namely home, industry and restaurant. In this, a fluent analysis is conducted on elliptical and circular cross section duct to obtain the variation of velocity and pressure magnitude at critical locations of duct. The computational fluid dynamic analysis is done and verified by simulations in ANSYS workbench. Results achieved from a mentioned analysis were used in optimization of the duct used for various applications like home, industry and restaurant. Geometry is analyzed for different working conditions under different velocity inputs

Design and Optimization of a Duct in Different Working Conditions for Circular and Elliptical Section

The objective is to evaluate and compare the computational fluid dynamic analysis of duct under three types of working conditions namely home, industry and restaurant. In this, a fluent analysis is conducted on elliptical and circular cross section duct to obtain the variation of velocity and pressure magnitude at critical locations of duct. The computational fluid dynamic analysis is done and verified by simulations in ANSYS workbench. Results achieved from a mentioned analysis were used in optimization of the duct used for various applications like home, industry and restaurant. Geometry is analyzed for different working conditions under different velocity inputs

IBTの1905年シカゴ・ストライキ

97-102The ST mode of the Indian MST radar has become operational recently for preliminary observations. The vertical velocity is one of the important atmospheric parameters from a meteorological point of view. Some vertical velocity measurements made on 19 Sep. 1991 using two orthogonal polarization of the array, which are phased independently, are found to be self-consistent. This indicates that array phasing is correct and the radar can be used for the vertical velocity measurements for the study of atmospheric convection

Altered Development of the Dorsolateral Prefrontal Cortex in Chromosome 22q11.2 Deletion Syndrome: An In Vivo Proton Spectroscopy Study

Chromosome 22q11.2 deletion syndrome (22q11DS), the most common microdeletion in humans, is associated with multiple medical features, almost universal cognitive deficits, and a high-risk of schizophrenia. The metabolic basis of the psychological/psychiatric features is not well understood. Volumetric brain imaging studies have shown that gray matter abnormalities in the dorsolateral prefrontal cortex (DLPFC), an area that is believed to be integral for higher neurocognition, as well as being involved in schizophrenia, are associated with the psychological manifestations. However, studies have not characterized any possible metabolite alterations within the DLPFC of children with 22q11DS and their correlations with the psychological findings