Automated Design of Tissue Engineering Scaffolds by Advanced CAD

The design of scaffolds with an intricate and controlled internal structure represents a challenge for Tissue Engineering. Several scaffold manufacturing techniques allow the creation of complex and random architectures, but have little or no control over geometrical parameters such as pore size, shape and interconnectivity- things that are essential for tissue regeneration. The combined use of CAD software and layer manufacturing techniques allow a high degree of control over those parameters, resulting in reproducible geometrical architectures. However, the design of the complex and intricate network of channels that are required in conventional CAD, is extremely time consuming: manually setting thousands of different geometrical parameters may require several days in which to design the individual scaffold structures. This research proposes an automated design methodology in order to overcome those limitations. The combined use of Object Oriented Programming and advanced CAD software, allows the rapid generation of thousands of different geometrical elements. Each has a different set of parameters that can be changed by the software, either randomly or according to a given mathematical formula, so that they match the different distribution of geometrical elements such as pore size and pore interconnectivity. This work describes a methodology that has been used to design five cubic scaffolds with pore size ranging from about 200 to 800 µm, each with an increased complexity of the internal geometry.Mechanical Engineerin

The synthesis of some acylglycines and related oxazolones

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Vision-model-based Real-time Localization of Unmanned Aerial Vehicle for Autonomous Structure Inspection under GPS-denied Environment

UAVs have been widely used in visual inspections of buildings, bridges and other structures. In either outdoor autonomous or semi-autonomous flights missions strong GPS signal is vital for UAV to locate its own positions. However, strong GPS signal is not always available, and it can degrade or fully loss underneath large structures or close to power lines, which can cause serious control issues or even UAV crashes. Such limitations highly restricted the applications of UAV as a routine inspection tool in various domains. In this paper a vision-model-based real-time self-positioning method is proposed to support autonomous aerial inspection without the need of GPS support. Compared to other localization methods that requires additional onboard sensors, the proposed method uses a single camera to continuously estimate the inflight poses of UAV. Each step of the proposed method is discussed in detail, and its performance is tested through an indoor test case.Comment: 8 pages, 5 figures, submitted to i3ce 201

Coherent energy migration in solids: Determination of the average coherence length in one‐dimensional systems using tunable dye lasers

The coherent nature of energy propagation in solids at low temperatures was established from the time resolved response of the crystal to short optical pulses obtained from a dye laser (pumped by a nitrogen gas laser). The trapping and detrapping of the energy by shallow defects (x traps) was evident in the spectra and enabled us to extract the coherence length: l≳700 Å=186 molecules for the one‐dimensional triplet excitons of 1,2,4,5‐tetrachlorobenzene crystals at T<4.2° K. This length which clearly exceeds the stochastic random walk limit is related to the thermalization mechanisms in this coupled exciton–trap system, and its magnitude supports the notion that exciton–phonon coupling is responsible for the loss of coherence on very long molecular chains (trap concentration is 1/256 000)

Early Pathways Therapy for Young Children in Poverty: A Randomized Controlled Trial

Early Pathways is a home-based, parent and child therapy program for the treatment of disruptive behaviors among young children living in poverty. In this study, 199 clinically referred children were randomly assigned to an immediate treatment (IT) or wait-list control (WL) conditions. Results indicated that parents in the IT condition reported significant improvements in their child’s disruptive and prosocial behaviors and increased nurturing and decreased use of corporal and verbal punishment by their parents compared to the WL families. Gains were maintained for children in both the IT and WL conditions at 3-month follow-up

A Portable, Low-Cost Wheelchair Ergometer Design Based on a Mathematical Model of Pediatric Wheelchair Dynamics

Evaluation and training of wheelchair propulsion improves efficiency and prevents orthopaedic injury in pediatric manual wheelchair users. Ergometers allow static propulsion and emulate typical conditions. Currently available ergometers have deficiencies that limit their use in motion analysis. A new ergometer is developed and evaluated based on a model of wheelchair inertial dynamics that eliminates these deficiencies. This makes integrated motion analysis of wheelchair propulsion in current community, home, and international outreach efforts possible