Simulation of the response of a silicon pixel detector

A model to simulate the response of a silicon pixel detector is described. The effects of geometrical charge sharing, electronic noise threshold dispersion, capacitive coupling between pixel channels and d -rays production have been taken into account. The model has been tested on the Omega3chip, which is the direct predecessor of the ALICE pixel detector, to be used in the inner tracking system of the ALICE experiment. The model is able to reproduce the experimental data and the resulting parameters are consistent with the measurements made on the Omega3chip. Key words:silicon pixel, simulation PACS:07.05.T,29.40.

The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system

Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years. The ability of the N-acetyl phenylalanine glucosamine derivative (NAPA) to increase anabolism and reduce catabolism via inhibition of IKKα kinase has been previously observed in vitro and in vivo. The present study aims to confirm the chondroprotective effects of NAPA in an in vitro model of joint OA established with primary cells, respecting both the crosstalk between chondrocytes and synoviocytes and their phenotypes. This model satisfactorily reproduces some features of the previously investigated DMM model, such as the prominent induction of ADAMTS-5 upon inflammatory stimulation. Both gene and protein expression analysis indicated the ability of NAPA to counteract key cartilage catabolic enzymes (ADAMTS-5) and effectors (MCP-1). Molecular analysis showed the ability of NAPA to reduce IKKα nuclear translocation and H3Ser10 phosphorylation, thus inhibiting IKKα transactivation of NF-κB signalling, a pivotal step in the NF-κB-dependent gene expression of some of its targets. In conclusion, our data confirm that NAPA could truly act as a disease-modifying drug in OA

The Effects of Massage Therapy by the Patients Relative on Vital Signs of Males Admitted in Critical Care Unit

Background: Changes in vital signs may affect the myocardial oxygen demand. Massage therapy has been used in intensive care units to relive patients’ physical and psychological problems. In all of the studies massaging has been done by a nurse and the patients’ family did not have any role. Objectives: The present study aimed to examine the effects of massage therapy by patient’s relative on vital signs of patients with acute coronary syndrome and acute myocardial infarction. Patients and Methods: A randomized controlled trial was conducted on 60 male patients hospitalized in coronary care units. In the intervention group, massage therapy was done by one of the patient’s male relatives on the third day of admission. The control group only received the routine care. Vital signs were recorded before and after the massage therapy session. SPSS 11.5 software was employed to analyze data using qui-square, Fischer exact test, independent t-test, paired t-test and descriptive statistics. Results: The pre intervention mean of systolic blood pressure of the intervention group were 126.36 ± 16.80 and changed to 121.70 ± 13.31 after the massage therapy session (P = 0.021). The mean pulse rate of the intervention group was 79.46 ± 10.41 and reached 69.30 ± 9.47 after the intervention (P = 0.001). The mean respiration rate of the intervention group also decreased after massage (P = 0.001). No significant changes were observed in diastolic blood pressure and temperature of the intervention group. No significant changes were observed in vital signs of the control group either. Conclusions: Massage therapy by the patients’ relative, decreased systolic blood pressure, pulse and respiration rates of patients admitted in critical care Unite (CCU). Because of the useful effects of those changes, it can be recommended that massage therapy by a member of the patient’s family be used to balance vital signs of patients admitted in CCU. This study was registered at Iranian Registry of Clinical Trials (IRCT). The registration number of the study is IRCT201112048296N

The absolute age of the globular cluster M15 using near-infrared adaptive optics images from PISCES/LBT

We present deep near-infrared (NIR) J, Ks photometry of the old, metal-poor Galactic globular cluster M\,15 obtained with images collected with the LUCI1 and PISCES cameras available at the Large Binocular Telescope (LBT). We show how the use of First Light Adaptive Optics system coupled with the (FLAO) PISCES camera allows us to improve the limiting magnitude by ~2 mag in Ks. By analyzing archival HST data, we demonstrate that the quality of the LBT/PISCES color magnitude diagram is fully comparable with analogous space-based data. The smaller field of view is balanced by the shorter exposure time required to reach a similar photometric limit. We investigated the absolute age of M\,15 by means of two methods: i) by determining the age from the position of the main sequence turn-off; and ii) by the magnitude difference between the MSTO and the well-defined knee detected along the faint portion of the MS. We derive consistent values of the absolute age of M15, that is 12.9+-2.6 Gyr and 13.3+-1.1 Gyr, respectively.Comment: 13 pages, 8 figures, ApJ accepte

Kemampuan Menulis Kalimat Efektif Siswa Kelas XI SMA Negeri 1 Rambah Kabupaten Rokan Hulu

The problem in this study show the ability of students to writes of effective sentence eleven grade students of SMA Negeri 1 Rambah Rokan Hulu regency. This study aims to determine the ability to write of affective sentence eleven grade students of SMA Negeri 1 Rambah Rokan Hulu regency. This research used quantitative descriptive method. Data collected by the technique of arranging test. The sample is 15% from each grade XI is that 37 students. The results showed that ability of students to writes of effective sentence eleven grade students of SMA Negeri 1 Rambah Rokan Hulu regency is sufficient. Can be seenfrom the 37 students as a source of research data there were 29 respondents were able to write effective sentences and 8 respondents are not able to. Based on observations of researchers, most mistakes made by students is an error equivalence, especially malfunctions sentence, in others students are able to

QGP fireball explosion

We identify the major physics milestones in the development of strange hadrons as an observable for both the formation of quark-gluon plasma, and of the ensuing explosive disintegration of deconfined matter fireball formed in relativistic heavy ion collisions at 160--20A GeV. We describe the physical properties of QGP phase and show agreement with the expectations based on an analysis of hadron abundances. We than also demonstrate that the m_t shape of hadron spectra is in qualitative agreement with the sudden breakup of a supercooled QGP fireball.Comment: 10 pages, incl. 4 figures J. Phys. G in press; presented at STRANGENESS2000 International Conference, Berkeley July 200

Co-axial dual-core resonant leaky fibre for optical amplifiers

We present a co-axial dual-core resonant leaky optical fibre design, in which the outer core is made highly leaky. A suitable choice of parameters can enable us to resonantly couple power from the inner core to the outer core. In a large-core fibre, such a resonant coupling can considerably increase the differential leakage loss between the fundamental and the higher order modes and can result in effective single-mode operation. In a small-core single-mode fibre, such a coupling can lead to sharp increase in the wavelength dependent leakage loss near the resonant wavelength and can be utilized for the suppression of amplified spontaneous emission and thereby gain equalization of an optical amplifier. We study the propagation characteristics of the fibre using the transfer matrix method and present an example of each, the large-mode-area design for high power amplifiers and the wavelength tunable leakage loss design for inherent gain equalization of optical amplifiers.Comment: 6 page

Prospect for Charge Current Neutrino Interactions Measurements at the CERN-PS

Tensions in several phenomenological models grew with experimental results on neutrino/antineutrino oscillations at Short-Baseline (SBL) and with the recent, carefully recomputed, antineutrino fluxes from nuclear reactors. At a refurbished SBL CERN-PS facility an experiment aimed to address the open issues has been proposed [1], based on the technology of imaging in ultra-pure cryogenic Liquid Argon (LAr). Motivated by this scenario a detailed study of the physics case was performed. We tackled specific physics models and we optimized the neutrino beam through a full simulation. Experimental aspects not fully covered by the LAr detection, i.e. the measurements of the lepton charge on event-by-event basis and their energy over a wide range, were also investigated. Indeed the muon leptons from Charged Current (CC) (anti-)neutrino interactions play an important role in disentangling different phenomenological scenarios provided their charge state is determined. Also, the study of muon appearance/disappearance can benefit of the large statistics of CC muon events from the primary neutrino beam. Results of our study are reported in detail in this proposal. We aim to design, construct and install two Spectrometers at "NEAR" and "FAR" sites of the SBL CERN-PS, compatible with the already proposed LAr detectors. Profiting of the large mass of the two Spectrometers their stand-alone performances have also been exploited.Comment: 70 pages, 38 figures. Proposal submitted to SPS-C, CER

Beam Test Performance and Simulation of Prototypes for the ALICE Silicon Pixel Detector

The silicon pixel detector (SPD) of the ALICE experiment in preparation at the Large Hadron Collider (LHC) at CERN is designed to provide the precise vertex reconstruction needed for measuring heavy flavor production in heavy ion collisions at very high energies and high multiplicity. The SPD forms the innermost part of the Inner Tracking System (ITS) which also includes silicon drift and silicon strip detectors. Single assembly prototypes of the ALICE SPD have been tested at the CERN SPS using high energy proton/pion beams in 2002 and 2003. We report on the experimental determination of the spatial precision. We also report on the first combined beam test with prototypes of the other ITS silicon detector technologies at the CERN SPS in November 2004. The issue of SPD simulation is briefly discussed.Comment: 4 pages, 5 figures, prepared for proceedings of 7th International Position Sensitive Detectors Conference, Liverpool, Sept. 200

Production of Λ6^{6}_{\Lambda}H and Λ7^{7}_{\Lambda}H with the (Kstop−^{-}_{stop},π+\pi^+) reaction

The production of neutron rich $\Lambda$-hypernuclei via the ($K^-_stop$,$\pi^+$) reaction has been studied using data collected with the FINUDA spectrometer at the DA$\Phi$NE $\phi$-factory (LNF). The analysis of the inclusive $\pi^+$ momentum spectra is presented and an upper limit for the production of $^6_\Lambda$H and $^7_\Lambda$H from $^6$Li and $^7$Li, is assessed for the first time.Comment: 11 pages, 3 figures. Accepted for publication in PL