64 research outputs found
Classical Scattering for a driven inverted Gaussian potential in terms of the chaotic invariant set
We study the classical electron scattering from a driven inverted Gaussian
potential, an open system, in terms of its chaotic invariant set. This chaotic
invariant set is described by a ternary horseshoe construction on an
appropriate Poincare surface of section. We find the development parameters
that describe the hyperbolic component of the chaotic invariant set. In
addition, we show that the hierarchical structure of the fractal set of
singularities of the scattering functions is the same as the structure of the
chaotic invariant set. Finally, we construct a symbolic encoding of the
hierarchical structure of the set of singularities of the scattering functions
and use concepts from the thermodynamical formalism to obtain one of the
measures of chaos of the fractal set of singularities, the topological entropy.Comment: accepted in Phy. Rev.
Quantum and classical echoes in scattering systems described by simple Smale horseshoes
We explore the quantum scattering of systems classically described by binary
and other low order Smale horseshoes, in a stage of development where the
stable island associated with the inner periodic orbit is large, but chaos
around this island is well developed. For short incoming pulses we find
periodic echoes modulating an exponential decay over many periods. The period
is directly related to the development stage of the horseshoe. We exemplify our
studies with a one-dimensional system periodically kicked in time and we
mention possible experiments.Comment: 7 pages with 6 reduced quality figures! Please contact the authors
([email protected]) for an original good quality pre-prin
Self-pulsing effect in chaotic scattering
We study the quantum and classical scattering of Hamiltonian systems whose
chaotic saddle is described by binary or ternary horseshoes. We are interested
in parameters of the system for which a stable island, associated with the
inner fundamental periodic orbit of the system exists and is large, but chaos
around this island is well developed. In this situation, in classical systems,
decay from the interaction region is algebraic, while in quantum systems it is
exponential due to tunneling. In both cases, the most surprising effect is a
periodic response to an incoming wave packet. The period of this self-pulsing
effect or scattering echoes coincides with the mean period, by which the
scattering trajectories rotate around the stable orbit. This period of rotation
is directly related to the development stage of the underlying horseshoe.
Therefore the predicted echoes will provide experimental access to topological
information. We numerically test these results in kicked one dimensional models
and in open billiards.Comment: Submitted to New Journal of Physics. Two movies (not included) and
full-resolution figures are available at http://www.cicc.unam.mx/~mejia
Phase-Space Volume of Regions of Trapped Motion: Multiple Ring Components and Arcs
The phase--space volume of regions of regular or trapped motion, for bounded
or scattering systems with two degrees of freedom respectively, displays
universal properties. In particular, sudden reductions in the phase-space
volume or gaps are observed at specific values of the parameter which tunes the
dynamics; these locations are approximated by the stability resonances. The
latter are defined by a resonant condition on the stability exponents of a
central linearly stable periodic orbit. We show that, for more than two degrees
of freedom, these resonances can be excited opening up gaps, which effectively
separate and reduce the regions of trapped motion in phase space. Using the
scattering approach to narrow rings and a billiard system as example, we
demonstrate that this mechanism yields rings with two or more components. Arcs
are also obtained, specifically when an additional (mean-motion) resonance
condition is met. We obtain a complete representation of the phase-space volume
occupied by the regions of trapped motion.Comment: 19 pages, 17 figure
The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages
The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, but our understanding remains limited regarding the molecular determinants of repression. Here we show that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during in vitro and in vivo alternative macrophage polarization. Repression results in decreased lineage-determining transcription factor, p300, and RNA polymerase II binding followed by reduced enhancer RNA expression, H3K27 acetylation, and chromatin accessibility. The repressor function of STAT6 is HDAC3 dependent on a subset of IL-4-repressed genes. In addition, STAT6-repressed enhancers show extensive overlap with the NF-κB p65 cistrome and exhibit decreased responsiveness to lipopolysaccharide after IL-4 stimulus on a subset of genes. As a consequence, macrophages exhibit diminished inflammasome activation, decreased IL-1β production, and pyroptosis. Thus, the IL-4-STAT6 signaling pathway establishes an alternative polarization-specific epigenenomic signature resulting in dampened macrophage responsiveness to inflammatory stimuli
Measuring Cosmic Rays with the RadMap Telescope on the International Space Station
The RadMap Telescope is a new radiation-monitoring instrument operating in the U.S. Orbital
Segment (USOS) of the International Space Station (ISS). The instrument was commissioned in
May 2023 and will rotate through four locations inside American, European, and Japanese modules
over a period of about six months. In some locations, it will take data alongside operational,
validated detectors for a cross-check of measurements. RadMap’s central detector is a finely
segmented tracking calorimeter that records detailed depth-dose data relevant to studies of the
radiation exposure of the ISS crew. It is also able to record particle-dependent energy spectra of
cosmic-ray nuclei with energies up to several hundred MeV per nucleon. A unique feature of the
detector is its ability to track nuclei with omnidirectional sensitivity at an angular resolution of two
degrees. In this contribution, we present the design and capabilities of the RadMap Telescope and
give an overview of the instrument’s commissioning on the ISS
Cardiovascular effects of sub-daily levels of ambient fine particles: a systematic review
<p>Abstract</p> <p>Background</p> <p>While the effects of daily fine particulate exposure (PM) have been well reviewed, the epidemiological and physiological evidence of cardiovascular effects associated to sub-daily exposures has not. We performed a theoretical model-driven systematic non-meta-analytical literature review to document the association between PM sub-daily exposures (≤6 hours) and arrhythmia, ischemia and myocardial infarction (MI) as well as the likely mechanisms by which sub-daily PM exposures might induce these acute cardiovascular effects. This review was motivated by the assessment of the risk of exposure to elevated sub-daily levels of PM during fireworks displays.</p> <p>Methods</p> <p>Medline and Elsevier's EMBase were consulted for the years 1996-2008. Search keywords covered potential cardiovascular effects, the pollutant of interest and the short duration of the exposure. Only epidemiological and experimental studies of adult humans (age > 18 yrs) published in English were reviewed. Information on design, population and PM exposure characteristics, and presence of an association with selected cardiovascular effects or physiological assessments was extracted from retrieved articles.</p> <p>Results</p> <p>Of 231 articles identified, 49 were reviewed. Of these, 17 addressed the relationship between sub-daily exposures to PM and cardiovascular effects: five assessed ST-segment depression indicating ischemia, eight assessed arrhythmia or fibrillation and five considered MI. Epidemiologic studies suggest that exposure to sub-daily levels of PM is associated with MI and ischemic events in the elderly. Epidemiological studies of sub-daily exposures suggest a plausible biological mechanism involving the autonomic nervous system while experimental studies suggest that vasomotor dysfunction may also relate to the occurrence of MI and ischemic events.</p> <p>Conclusions</p> <p>Future studies should clarify associations between cardiovascular effects of sub-daily PM exposure with PM size fraction and concurrent gaseous pollutant exposures. Experimental studies appear more promising for elucidating the physiological mechanisms, time courses and causes than epidemiological studies which employ central pollution monitors for measuring effects and for assessing their time course. Although further studies are needed to strengthen the evidence, given that exposure to sub-daily high levels of PM (for a few hours) is frequent and given the suggestive evidence that sub-daily PM exposures are associated with the occurrence of cardiovascular effects, we recommend that persons with cardiovascular diseases avoid such situations.</p
Ultrafeine Aerosolpartikel in der Außenluft: Perspektiven zur Aufklärung ihrer Gesundheitseffekte.
Der Beitrag zeigt Perspektiven für die Erforschung der gesundheitlichen Wirkung ultrafeiner Aerosolpartikel (UFP; Durchmesser < 100 nm) in der Außenluft auf. Obwohl UFP derzeit nicht Teil der gesetzlich geregelten Luftschadstoffe sind, legen ca. 50 epidemiologische Einzelstudien und toxikologische Erkenntnisse nahe, dass von UFP in der Außenluft eine schädliche Wirkung auf die menschliche Gesundheit ausgeht. In den kommenden Jahren werden in Deutschland einerseits große Mengen von Gesundheitsdaten im Rahmen der Nationalen Kohorte (NAKO) erzeugt, andererseits signifikante Datenmengen von UFP durch das GUAN-Messnetz (GUAN: German Ultrafine Aerosol Network) erhoben. Es wird vorgeschlagen, diese Ressourcen in Form dreier konkreter epidemiologischer Studientypen für die Gesundheitsforschung an UFP zu nutzen: a) Zeitreihenstudien zu Kurzzeiteffekten (Sterberegister, Notfalleinsätze, Krankenhauseinweisungen), b) Kohortenstudien zu Langzeiteffekten sowie c) Panelstudien zu Kurzzeiteffekten
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