10 research outputs found
Connecting Binuclear Pd(III) and Mononuclear Pd(IV) Chemistry by PdâPd Bond Cleavage
Oxidation of binuclear PdÂ(II) complexes with PhICl<sub>2</sub> or
PhIÂ(OAc)<sub>2</sub> has previously been shown to afford binuclear
PdÂ(III) complexes featuring a PdâPd bond. In contrast, oxidation
of binuclear PdÂ(II) complexes with electrophilic trifluoromethylating
(âCF<sub>3</sub><sup>+</sup>â) reagents has been reported
to afford mononuclear PdÂ(IV) complexes. Herein, we report experimental
and computational studies of the oxidation of a binuclear PdÂ(II) complex
with âCF<sub>3</sub><sup>+</sup>â reagents. These studies
suggest that a mononuclear PdÂ(IV) complex is generated by an oxidationâfragmentation
sequence proceeding via fragmentation of an initially formed, formally
binuclear PdÂ(III), intermediate. The observation that binuclear PdÂ(III)
and mononuclear PdÂ(IV) complexes are accessible in the same reactions
offers an opportunity for understanding the role of nuclearity in
both oxidation and subsequent CâX bond-forming reactions
Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders
Background: Antidepressant medication and running therapy are both effective treatments for patients with depressive and anxiety disorders. However, they may work through different pathophysiological mechanisms and could differ in their impact on physical health. This study examined effects of antidepressants versus running therapy on both mental and physical health. Methods: According to a partially randomized patient preference design, 141 patients with depression and/or anxiety disorder were randomized or offered preferred 16-week treatment: antidepressant medication (escitalopram or sertraline) or group-based running therapy â„2 per week. Baseline (T0) and post-treatment assessment at week 16 (T16) included mental (diagnosis status and symptom severity) and physical health indicators (metabolic and immune indicators, heart rate (variability), weight, lung function, hand grip strength, fitness). Results: Of the 141 participants (mean age 38.2 years; 58.2 % female), 45 participants received antidepressant medication and 96 underwent running therapy. Intention-to-treat analyses showed that remission rates at T16 were comparable (antidepressants: 44.8 %; running: 43.3 %; p = .881). However, the groups differed significantly on various changes in physical health: weight (d = 0.57; p = .001), waist circumference (d = 0.44; p = .011), systolic (d = 0.45; p = .011) and diastolic (d = 0.53; p = .002) blood pressure, heart rate (d = 0.36; p = .033) and heart rate variability (d = 0.48; p = .006). Limitations: A minority of the participants was willing to be randomized; the running therapy was larger due to greater preference for this intervention. Conclusions: While the interventions had comparable effects on mental health, running therapy outperformed antidepressants on physical health, due to both larger improvements in the running therapy group as well as larger deterioration in the antidepressant group. Trial registration: Trialregister.nl Number of identification: NTR3460