473 research outputs found
Modulation of hippocampal acetylcholine release - a potent central action of interleukin-2
The potential of the T-cell growth factor interleukin-2 (IL-2) to modulate the release of ACh from rat hippocampus was studied in vitro, as a means to investigate the possible functional significance of this cytokine in the CNS. Hippocampal slices were superfused with Krebs' buffer medium, and endogenous ACh released into the superfusate was measured using a radioenzymatic assay. Recombinant human IL-2 present during a stimulation with 25 mM KCl altered, in a concentration-dependent manner, the evoked transmitter release. At a concentration of 15 U/ml (< or = 1 nM), IL-2 inhibited ACh release by more than 50% of the control level (evoked ACh release from the untreated contralateral hemispheres). Inhibition was observed within 20 min of tissue exposure to IL-2 and lasted for up to 1 hr. The inhibitory effect of IL-2 was reversible since transient tissue exposure to IL-2 did not affect subsequent evoked ACh release. IL-2 at this concentration also significantly decreased evoked ACh in frontal cortical slices, but was ineffective in the parietal cortex and striatum, revealing that IL-2 selectively modulates the release of ACh from certain, but not all, cholinergic nerve terminals in the CNS. At very low concentrations (1.5 mU/ml, < or = 0.1 pM), IL-2 transiently increased hippocampal evoked ACh release, resulting in a biphasic dose-response profile with no significant effect observed at 0.015 mU/ml (< or = 1 fM). Other cytokines (IL-1 alpha, IL-3, IL-5, IL-6, interferon alpha), tested in hippocampal slice incubations, failed to modulate ACh release
3D sensors for the HL-LHC
In order to increase its discovery potential, the Large Hadron Collider (LHC)
accelerator will be upgraded in the next decade. The high luminosity LHC
(HL-LHC) period demands new sensor technologies to cope with increasing
radiation fluences and particle rates. The ATLAS experiment will replace the
entire inner tracking detector with a completely new silicon-only system. 3D
pixel sensors are promising candidates for the innermost layers of the Pixel
detector due to their excellent radiation hardness at low operation voltages
and low power dissipation at moderate temperatures. Recent developments of 3D
sensors for the HL-LHC are presented.Comment: 8 pages, 5 figures, International Workshops on Radiation Imaging
Detectors 201
Silicon-based three-dimensional microstructures for radiation dosimetry in hadrontherapy
In this work, we propose a solid-state-detector for use in radiation microdosimetry. This device improves the performance of existing dosimeters using customized 3D-cylindrical microstructures etched inside silicon. The microdosimeter consists of an array of micro-sensors that have 3D-cylindrical electrodes of 15 μm diameter and a depth of 5 μm within a silicon membrane, resulting in a well-defined micrometric radiation sensitive volume. These microdetectors have been characterized using an 241Am source to assess their performance as radiation detectors in a high-LET environment. This letter demonstrates the capability of this microdetector to be used to measure dose and LET in hadrontherapy centers for treatment plan verification as part of their patient-specific quality control program
Toward a New Kind of Asteroseismic Grid Fitting
Recent developments in instrumentation (e.g., in particular the Kepler and
CoRoT satellites) provide a new opportunity to improve the models of stellar
pulsations. Surface layers, rotation, and magnetic fields imprint erratic
frequency shifts, trends, and other non-random behavior in the frequency
spectra. As our observational uncertainties become smaller, these are
increasingly important and difficult to deal with using standard fitting
techniques. To improve the models, new ways to compare their predictions with
observations need to be conceived. In this paper we present a completely
probabilistic (Bayesian) approach to asteroseismic model fitting. It allows for
varying degrees of prior mode identification, corrections for the discrete
nature of the grid, and most importantly implements a treatment of systematic
errors, such as the "surface effects." It removes the need to apply semi-
empirical corrections to the observations prior to fitting them to the models
and results in a consistent set of probabilities with which the model physics
can be probed and compared. As an example, we show a detailed asteroseismic
analysis of the Sun. We find a most probable solar age, including a 35 +- 5
million year pre-main sequence phase, of 4.591 billion years, and initial
element mass fractions of X_0 = 0.72, Y_0 = 0.264, Z_0 = 0.016, consistent with
recent asteroseismic and non-asteroseismic studies.Comment: 15 pages, 5 figures, accepted for publication in The Astrophysical
Journal; v2 contains minor changes made in the proofs (updated references &
corrected typos
Inverse Low Gain Avalanche Detectors (iLGADs) for precise tracking and timing applications
Low Gain Avalanche Detector (LGAD) is the baseline sensing technology of the
recently proposed Minimum Ionizing Particle (MIP) end-cap timing detectors
(MTD) at the Atlas and CMS experiments. The current MTD sensor is designed as a
multi-pad matrix detector delivering a poor position resolution, due to the
relatively large pad area, around 1 ; and a good timing resolution,
around 20-30 ps. Besides, in his current technological incarnation, the timing
resolution of the MTD LGAD sensors is severely degraded once the MIP particle
hits the inter-pad region since the signal amplification is missing for this
region. This limitation is named as the LGAD fill-factor problem. To overcome
the fill factor problem and the poor position resolution of the MTD LGAD
sensors, a p-in-p LGAD (iLGAD) was introduced. Contrary to the conventional
LGAD, the iLGAD has a non-segmented deep p-well (the multiplication layer).
Therefore, iLGADs should ideally present a constant gain value over all the
sensitive region of the device without gain drops between the signal collecting
electrodes; in other words, iLGADs should have a 100 fill-factor by
design. In this paper, tracking and timing performance of the first iLGAD
prototypes is presented.Comment: Conference Proceedings of VCI2019, 15th Vienna Conference of
Instrumentation, February 18-22, 2019, Vienna, Austri
Recent Technological Developments on LGAD and iLGAD Detectors for Tracking and Timing Applications
This paper reports the last technological development on the Low Gain
Avalanche Detector (LGAD) and introduces a new architecture of these detectors
called inverse-LGAD (iLGAD). Both approaches are based on the standard
Avalanche Photo Diodes (APD) concept, commonly used in optical and X-ray
detection applications, including an internal multiplication of the charge
generated by radiation. The multiplication is inherent to the basic n++-p+-p
structure, where the doping profile of the p+ layer is optimized to achieve
high field and high impact ionization at the junction. The LGAD structures are
optimized for applications such as tracking or timing detectors for high energy
physics experiments or medical applications where time resolution lower than 30
ps is required. Detailed TCAD device simulations together with the electrical
and charge collection measurements are presented through this work.Comment: Keywords: silicon detectors, avalanche multiplication, timing
detectors, tracking detectors. 8 pages. 8 Figure
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