2 research outputs found
Trends in hip fracture in patients with rheumatoid arthritis: Results from the Spanish National Inpatient Registry over a 17-year period (1999–2015). TREND-AR study
Purpose T o analyse trends in hip fracture (HF) rates in
patients with rheumatoid arthritis (RA) over an extended
time period (17 years).
Methods T his observational retrospective survey
was performed by reviewing data from the National
Surveillance System for Hospital Data, which includes
more than 98% of Spanish hospitals. All hospitalisations
of patients with RA and HF that were reported from 1999
to 2015 were analysed. Codes were selected using the
Ninth International Classification of Diseases, Clinical
Modification: ICD-9-CM: RA 714.0 to 714.9 and HF 820.0
to 820.3. The crude and age-adjusted incidence rate of
HF was calculated by age and sex strata over the last
17 years. General lineal models were used to analyse
trends.
Results Between 1999 and 2015, 6656 HFs occurred
in patients with RA of all ages (84.25% women, mean
age 77.5 and 15.75% men, mean age 76.37). The ageadjusted
osteoporotic HF rate was 221.85/100 000
RA persons/ year (women 227.97; men 179.06). The HF
incidence rate increased yearly by 3.1% (95% CI 2.1 to
4.0) during the 1999–2015 period (p<0.001) and was
more pronounced in men (3.5% (95% CI 2.1 to 4.9)) than
in women (3.1% (95% CI 2.3 to 4.1)). The female to male
ratio decreased from 1.54 in 1999 to 1.14 in 2015.
The average length of hospital stays (ALHS) decreased
(p<0.001) from 16.76 days (SD 15.3) in 1999 to 10.78
days (SD 7.72) in 2015. Age at the time of hospitalisation
increased (p<0.001) from 75.3 years (SD 9.33) in 1999 to
79.92 years (SD 9.47) in 2015. There was a total of 326
(4.9%) deaths during admission, 247 (4.4%) in women and
79 (7.5%) in men (p<0.001).
Conclusion I n Spain, despite the advances that have
taken place in controlling disease activity and in treating
osteoporosis, the incidence rate of HF increased in both
male and female patients with RA.This work has a help for the research provided by the Society of Rheumatology of the Community of Madrid (SORCOM)
La fibronectina en la enfermedad crónica por inmunocomplejos y en un modelo de peritonitis séptica: efecto beneficioso de su administración
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 21 de Marzo de 1991