New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Controle de Chalcodermus Bimaculatus (Boheman) (Coleoptera: Curculionidae) no Solo com beaveria Bassiana (Bals.) Vuillemin e Metarhizium Anisopliae (Metsch) Sorokin.

Os fungos Beauveria bassiana e Metarhizium anisopliae foram testados sobre larvas do ultimo instar de Chalcodermus bimaculatus em condicoes de laboratorio e casa telada. Em laboratorio, os isolados E6, E9, Ma43 e CP218 de M. anisopliae foram altameate virulentos, matando 100% dos insetos na dosagem de 5,4 x 103 conidios/mm2, até sete dias apos o tratamento. Observou-se, tambem, que micelio e conidios de B. bassiana e M. anisopliae misturados ao solo mataram 100% das larvas, entretanto, no tratamento com micelio o tempo de mortalidade media das larvas foi maior. Em casa telada, conidios de B. bassiana e M. anisopliae, na dose equivalente a 240 g/ha, produziram aproximadamente 70% de mortalidade de larvas de C. bimaculatus.Made available in DSpace on 2011-04-09T12:15:09Z (GMT). No. of bitstreams: 1 pab09abresp92.pdf: 458879 bytes, checksum: 998f3aabfb234ffc582add54da771c74 (MD5) Previous issue date: 2001-08-22199

Controle de Chalcodermus Bimaculatus (Boheman) (Coleoptera: Curculionidae) no Solo com beaveria Bassiana (Bals.) Vuillemin e Metarhizium Anisopliae (Metsch) Sorokin.

Os fungos Beauveria bassiana e Metarhizium anisopliae foram testados sobre larvas do ultimo instar de Chalcodermus bimaculatus em condicoes de laboratorio e casa telada. Em laboratorio, os isolados E6, E9, Ma43 e CP218 de M. anisopliae foram altameate virulentos, matando 100% dos insetos na dosagem de 5,4 x 103 conidios/mm2, até sete dias apos o tratamento. Observou-se, tambem, que micelio e conidios de B. bassiana e M. anisopliae misturados ao solo mataram 100% das larvas, entretanto, no tratamento com micelio o tempo de mortalidade media das larvas foi maior. Em casa telada, conidios de B. bassiana e M. anisopliae, na dose equivalente a 240 g/ha, produziram aproximadamente 70% de mortalidade de larvas de C. bimaculatus

Earlier than expected introductions of the Bemisia tabaci B mitotype in Brazil reveal an unprecedented, rapid invasion history

During 1991, in Brazil, the presence of the exotic Bemisia tabaci B mitotype was reported in São Paulo state. However, the duration from the time of initial introduction to population upsurges is not known. To investigate whether the 1991 B mitotype outbreaks in Brazil originated in São Paulo or from migrating populations from neighboring introduction sites, country-wide field samples of B. tabaci archived from 1989–2005 collections were subjected to analysis of mitochondrial cytochrome oxidase I (mtCOI) and nuclear RNA-binding protein 15 (RP-15) sequences. The results of mtCOI sequence analysis identified all B. tabaci as the NAFME 8 haplotype of the B mitotype. Phylogenetic analyses of RP-15 sequences revealed that the B mitotype was likely a hybrid between a B type parent related to a haplotype Ethiopian endemism (NAFME 1–3), and an unidentified parent from the North Africa-Middle East (NAF-ME) region. Results provide the first evidence that this widely invasive B mitotype has evolved from a previously undocumented hybridization event. Samples from Rio de Janeiro (1989) and Ceará state (1990), respectively, are the earliest known B mitotype records in Brazil. A simulated migration for the 1989 introduction predicted a dispersal rate of 200–500 km/year, indicating that the population was unlikely to have reached Ceará by 1990. Results implicated two independent introductions of the B mitotype in Brazil in 1989 and 1990, that together were predicted to have contributed to the complete invasion of Brazil in only 30 generations. © 2022 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]