El Triásico de la región de Monterde-Alhama de Aragón (Provincia de Zaragoza)

Se estudian los materiales en facies Buntsandstein y Muschelkalk de los afloramientos triásicos situados entre Monterde y el Norte de Alhama de Aragón. Para ello se han levantado siete columnas estratigráficas, habiéndose obtenido dos de ellas con un mayor detalle. Después de establecerse seis grandes tramos (unidades litoestratigráficas informales), claramente diferenciables, se estudian las variaciones verticales dentro de cada uno de ellos, así como las relaciones entre los mismos. En las reconstrucciones paleogeográficas y en la evolución sedimentaria> se resalta tanto la existencia de importantes umbrales durante la génesis de las tres unidades inferiores, como la transición gradual de depósitos marinos a continentales, y la presencia de interrupciones sedimentarias que, a veces, originan paleosuelos bien desarrollados. [RÉSUMÉ] On a studié les materiaux en faciés Buntsandstein et Muschelkalk des afleurments triassiques compris entre Monterde et le nord d'Alhama de Aragón. On a levé sept colonnes, dont deux en détaille. Aprés avoir établi six unités litostratigraphiques informelles trés differentes, on a étudié les variations verticales de chaque une ainsi que ses relations mutuelles. On fait sortir des importants seuils pendant la genése des trois unités inferieures par les reconstructions paléogéographiques et l'evolution sédimentaire, ainsi que la transition paulatine des dépots continentaux a marins et divers interruptions de la sedimentation, soulignés parfois par des paleochenaux. [AB5TRACT] The Buntsandstein and Muschelkalk facies have been surveyed in the outcrops between Monterde and the North of Alhama de Aragón. Seven stratigraphic sections have been studied, two in greater detail. After stablishing six informal lithostratigraphical units, very different each other, thcir vertical variations are studied as well as their mutual relations. The palaeogeogi-aphic reconstructions and the sediníentary evolution point out the existence of several shoals during tSe genesis of tSe three lower units as well as tSe transition from continental to marine deposits and several sedimentary breaks, sometimes niarked by paleosoils

Empresa Autopartes Colombia

Nota: Las actividades se encuentran en el documento adjuntoNota: Este documento está sujeto a la Advertencia legal y condiciones de uso sobre las bases de datos de objetos de aprendizaje.La Junta Directiva de una compañía del sector metalmecánico dedicada a la fabricación de autopartes, se encontraba en una situación difícil debido a que se estaban tomando decisiones muy conservadoras con respecto a la innovación tanto administrativa como tecnológica para enfrentar el mundo global competitivo, en el cual la organización estaba operando. En varias ocasiones intentaron motivar a los demás miembros de la Junta Directiva para inducir rápidos cambios que llevaran a la organización a ser más competitiva, sin embargo, no encontraron respuesta positiva.Universidad EAN. Vicerrectoría de Investigacione

Geological factors of the Guadalajara landscapes (Central Spain) and their relevance to landscape studies

The landscapes of a territory are the consequence of its history; overlapped geological, vegetable and cultural histories usually exist on a landscape. At the Mediterranean domain, however, a translucent vegetation exists, and its history is closely related to the geologic and cultural histories, because low-technology agricultural uses on a different hardness rock background control vegetation. Thus, in areas like the Guadalajara province, the geologic composition and the human activities can be considered the primary conditions for landscape configuration. Both condition the typologies, distribution and relative importance of the geotic, biotic and anthropogenic components of landscapes. A complex network of interrelations among all them exists but, in the base of which lie the geology of the territory, included relief, because it has amore independent influence since man cannot modify the geologic factors; such as the colour of the rocks, the size and distribution of rock bodies, the palaeogeographic domains and the tectonic structure all which control landscape development and configuration. Moreover, geology influences conditions and even limit, the presence, typologies and development of the biotic and anthropogenic elements. These factors also have a major relevance for environmental management, educational and economic policy, and, in some cases, for environmental impact assessment

Hydroxychloroquine to prevent SARS-CoV-2 infection among healthcare workers: early termination of a phase 3, randomised, open-label, controlled clinical trial

OBJECTIVE: To assess the effectiveness and safety of hydroxychloroquine (HCQ) prophylaxis for the prevention of SARS-CoV-2 infection in healthcare workers (HCW) on duty during the COVID-19 pandemic. RESULTS: A total of 68 HCWs met the eligibility criteria were randomly allocated to receive HCQ (n = 36) or not (n = 32). There were no significant differences between groups in respects to age, gender, or medical history. Eight participants met the primary efficacy endpoint of SAR-CoV-2 infection during the study period; there was no difference in incidence of SARS-CoV-2 infections between both study arms (HCQ: 5 vs Control: 3, p = 0.538). The relative risk of SARS-CoV-2 infection in the HCQ arm was 1.69 compared to the control group (95%CI 0.41-7.11, p = 0.463); due to poor participant accrual, the resulting statistical power of the primary efficacy outcome was 11.54%. No serious adverse events occurred; however, two (2/36, 5.6%) participants no longer wished to participate in the study and withdrew consent due to recurring grade 1 and 2 adverse events. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT04414241. (Registered on June 4, 2020)

Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report

We present the case of a 64-year-old female with stage IV gastric adenocarcinoma, pulmonary, and abdominal wall metastases, and no history of cardiovascular disease. In palliative care, she received systemic cytotoxic treatment with fluorouracil, leucovorin, oxaliplatin, and docetaxel protocol, which was well tolerated over five cycles. During cycle 6, she presented with cardiovascular symptoms with hemodynamic consequences while receiving oxaliplatin injection without docetaxel or 5-fluorouracil. She was transferred to the emergency department and then to the intensive care unit. She developed no complications during the hospital stay and was discharged after 10 days with preserved systolic function and no structural changes at the myocardial level. The electrocardiogram, echocardiogram, cardiac catheterization, and magnetic resonance imaging findings indicated an oxaliplatin-associated Takotsubo syndrome. The immunochemistry analysis showed PD-L1 expression level TPS: 40% and the foundation one genomic profiling revealed high mutation load, microsatellite instability, and HER2 not found. The patient is currently asymptomatic and on pembrolizumab monotherapy with good tolerance and partial treatment response