Tidal Energy Fish Impact : method development to determine the impact of open water tidal energy converters on fish

The goals of the proposed project are: 1. to develop a robust method and experimental set‐up to determine behaviour of fish in the vicinity of tidal turbines and collision risk in the strong turbid currents of the Marsdiep based on DIDSON technology, 2. to provide a first insight and measure avoidance and collision rate of fish (and although the focus will be on fish, also if marine mammals such as harbour porpoises and seals approach the device this will be determined within the project), 3. to develop data analysis methodology since analysing large DIDSON datasets manually is very labour‐intensive and will enhance the efficiency of future large scale studies using DIDSON

Sustainable livelihoods to adaptive capabilities: a global learning journey in a small state, Zanzibar

This thesis takes global learning out of the formal setting of a Northern classroom to a rural community setting in the Global South as a social learning process. It begins with a critical reflection of a large EU project to develop a global learning programme as a Global North South initiative. The focus narrows to Zanzibar, a small island state, to critically reflect on the delivery of the programme. And then further to focus on the global social learning and change that occurred in a rural community setting in the north of the island. Through participatory action research, I investigate the relevance of global learning as a social learning process, how norms and rules are shaped within a community setting and how these enable social change towards sustainable livelihoods. The thesis splices the intersection between critical and social theories of learning and engagement, to include critical social theories of Habermas (1984) and Wals (2007); critical race theories of Giroux (1997) and Said (1994) and distributive justice and entitlements theories of Sen (1997) and Moser (1998). It demonstrates the importance of dissonance and a safe space for deliberative dialogue, to be able to consider the global pressures and forces on local realities as the precursor to social change towards sustainability. I conclude by relating the learning from this small island state to the wider world and the current discourse on quality of education in a community development context

Magnetic Resonance Thermometry at 7T for Real-Time Monitoring and Correction of Ultrasound Induced Mild Hyperthermia

While Magnetic Resonance Thermometry (MRT) has been extensively utilized for non-invasive temperature measurement, there is limited data on the use of high field (≥7T) scanners for this purpose. MR-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for localized hyperthermia and drug delivery. MRT based on the temperature sensitivity of the proton resonance frequency (PRF) has been implemented in both a tissue phantom and in vivo in a mouse Met-1 tumor model, using partial parallel imaging (PPI) to speed acquisition. An MRgFUS system capable of delivering a controlled 3D acoustic dose during real time MRT with proportional, integral, and derivative (PID) feedback control was developed and validated. Real-time MRT was validated in a tofu phantom with fluoroptic temperature measurements, and acoustic heating simulations were in good agreement with MR temperature maps. In an in vivo Met-1 mouse tumor, the real-time PID feedback control is capable of maintaining the desired temperature with high accuracy. We found that real time MR control of hyperthermia is feasible at high field, and k-space based PPI techniques may be implemented for increasing temporal resolution while maintaining temperature accuracy on the order of 1°C

Arrhythmogenic Remodeling of the Left Ventricle in a Porcine Model of Repaired Tetralogy of Fallot

International audienc

Functional categorization analysis of the most significant pathways represented in the microarray-generated list of the 54 most differentially expressed genes (Ingenuity software) in the RV Endocardium of rTOF pigs.

<p>The p-values (blue bars) were calculated using the right-tailed Fisher’s exact test. The threshold (yellow line) is set to a p-value = 0.05. The ratios (yellow dots and curve) represent the number of molecules of the experiment related to the number of total molecules involved in the pathways.</p

Fold change comparison between samples from the RV endocardium (rTOF (n = 7)r versus controls (n = 5)), RV epicardium (rTOF (n = 4) versus controls (n = 4)), LV epicardium (rTOF (n = 4) versus controls (n = 4)), and LV endorcadium (rTOF (n = 7) versus controls (n = 5)) based on microarray expression data of 14 genes.

<p>Statistical significance (*P <0.05, **P <0.01, ***P <0.001).</p><p>Fold change comparison between samples from the RV endocardium (rTOF (n = 7)r versus controls (n = 5)), RV epicardium (rTOF (n = 4) versus controls (n = 4)), LV epicardium (rTOF (n = 4) versus controls (n = 4)), and LV endorcadium (rTOF (n = 7) versus controls (n = 5)) based on microarray expression data of 14 genes.</p

Relative expression (RT-qPCR) of <i>BNP</i>, Serca2a (<i>ATP2A2</i>) and <i>KCNA5</i> genes in samples from the RV Endocardium of controls (grey bars) and rTOF (black bars) hearts.

<p>Transcript expression is normalized to the reference genes HPRT1 and GUSB. Two sided T-Test Statistical significance of n = 5 Controls and n = 7 rTOF hearts (*P <0.05, **P <0.01, ***P <0.001).</p