The effects of LHC civil engineering on the SPS and LEP machines

The LHC will utilise much of the existing LEP infrastructure but will require many new surface buildings and several smaller underground structures, two new transfer tunnels from the SPS to the LHC an d two huge cavern complexes to house the ATLAS and CMS experiments. Excavation for the underground structures will start while LEP and SPS are running, causig the existing tunnels in close proximity t o move. The predicted movements are of sufficient amplitude to prevent machine oepration if no precautions are taken

Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY

© The Author(s), 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 23 (2012): 853-863, doi:10.1091/mbc.E11-12-0992.Junction-mediating and regulatory protein (JMY) is a regulator of both transcription and actin filament assembly. In response to DNA damage, JMY accumulates in the nucleus and promotes p53-dependent apoptosis. JMY's actin-regulatory activity relies on a cluster of three actin-binding Wiskott–Aldrich syndrome protein homology 2 (WH2) domains that nucleate filaments directly and also promote nucleation activity of the Arp2/3 complex. In addition to these activities, we find that the WH2 cluster overlaps an atypical, bipartite nuclear localization sequence (NLS) and controls JMY's subcellular localization. Actin monomers bound to the WH2 domains block binding of importins to the NLS and prevent nuclear import of JMY. Mutations that impair actin binding, or cellular perturbations that induce actin filament assembly and decrease the concentration of monomeric actin in the cytoplasm, cause JMY to accumulate in the nucleus. DNA damage induces both cytoplasmic actin polymerization and nuclear import of JMY, and we find that damage-induced nuclear localization of JMY requires both the WH2/NLS region and importin β. On the basis of our results, we propose that actin assembly regulates nuclear import of JMY in response to DNA damage.This work was supported by grants from the National Institutes of Health, an American Heart Association Predoctoral Fellowship (J.B.Z.), the Robert Day Allen Fellowship Fund (J.B.Z.), and a National Science Foundation Predoctoral Fellowship (B.B.)

The Deformed Complex and the Formational Units

The formational units that appear in the available geological fuegian literature, and that are found within the Deformed Complex of the Fuegian Andes, are the Metamorfita Lapataia (i.e., Lapataia Metamorphites), and the Alvear, Lemaire, Yahgan and Beauvoir formations, Estratos (strata) de Policarpo and Estratos de Bahía Tethis.As an introduction to the elements of judgment that result from this study, the mentioned set of formational units is briefly reviewed here.Fil: Acevedo, Rogelio Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentin

Is pricing a way to affect share of fruits and vegetables in a diet?

Sahlgrenska Akademin vid Göteborgs universitet Avdelningen för invärtesmedicin och klinisk nutrition Sammanfattning Titel: Är priset ett sätt att påverka mängd frukt och grönsaker i kosten? Författare: Maria Popov Handledare: Heléne Bertéus Forslund Examinator: Ingrid Larsson Linje: Dietistprogrammet, 180/240 hp Typ av arbete: Examensarbete, 15 hp Datum: 2013-05-23 Bakgrund: Intag av frukt och grönsaker (FG) är viktigt för hälsan, bland annat för förekomst av fetma, diabetes och hjärt-kärlsjukdomar. I höginkomstländer är en ökning av FG-intaget önskvärd, då endast en liten del av befolkningen äter rekommenderade mängder, samtidigt som nämnda sjukdomar står för flest fall av ohälsa och död. Förutom generella informationskampanjer eller kostråd till individer finns ekonomiska metoder att påverka vad människor väljer att köpa. Syfte: Att undersöka om olika prissättning har samband till FG-intag eller -inköp. Sökväg: Sökningen gjordes i databaser PubMed, Scopus och Summon med sökord "vegetable consumption", "price/pricing policy" och "food choice" i olika kombinationer. Urvalskriterier: Studierna skulle vara gjorda under tiden efter 2000-talet på minst 18 år gamla personer i Nordamerika, Australien eller Europa, och undersöka prisändringar och FG-inköp. Vissa interventionsplatser och undersökta parametrar exkluderades. Datainsamling och analys: Elva artiklar valdes ut, varav fyra uppfyllde alla kriterier. De fyra granskades enligt SBU:s granskningsmallar och evidensstyrkan bedömdes enligt GU:s formulär. Resultat: En tvärsnittsstudie visade att högre FG-priser var associerade med lägre FG-intag, men förklarade inte ett möjligt orsakssamband. De tre resterande studierna var väldesignade RCT med verklighetstrogna köpsituationer och blandade grupper, men grupperna var små. Interventionen var olika stora rabatter på FG och resultaten i alla studier visade med signifikans att interventionsgrupperna köpte mer än kontroller. Underlaget bedömdes ha måttlig evidensstyrka. Slutsats: Resultaten är samstämmiga och signifikanta: prissänkning leder till större inköp av FG. Men det krävs fler studier på större grupper. Det finns dessutom andra faktorer som komplicerar bilden, till exempel köpt total kalorimängd och socioekonomisk tillhörighet.Sahlgrenska Academy at University of Gothenburg Department of Internal Medicine and Clinical Nutrition Abstract Title: Is pricing a way to affect share of fruits and vegetables in a diet? Author: Maria Popov Supervisor: Heléne Bertéus Forslund Examiner: Ingrid Larsson Programme: Dietician study programme, 180/240 ECTS Type of paper: Examination paper, 15 hp Date: May 23, 2013 Background: Fruits and vegetables (FV) are important for health, including occurrence of diabetes, obesity and cardiovascular diseases. Said diseases cause most cases of illness and death in high-income countries. Only a small part of the population achieves the FV-intake goal, so a higher FV-intake is desirable. Besides general information campaigns there is another method of influencing what people might buy. Objective: To examine whether different pricing is connected to FV-intake or –purchase. Search strategy: Databases PubMed, Scopus and Summon were searched with “vegetable consumption", "price/pricing policy" and "food choice” in different combinations. Selection criteria: Studies performed after year 2000 on at least 18 years old persons from North America, Europe or Australia, examining changes in FV-price and -purchase. Some additional parameters were excluded. Data collection and analysis: Eleven articles were selected, whereof four met all the criteria. They were reviewed and the evidence was compiled according to the certain templates. Main results: One cross-sectional study showed an association between higher FV-prices and lower FV-intake, but it didn’t explain any causation. Three RCTs with good design had small assorted groups who participated in realistic shopping situations. The intervention was different price discounts on FV. The studies showed consistent significant results of lower prices leading to higher FV-purchase. Evidence strength was deemed to be moderate. Conclusions: The lowering of prices on FV might increase FV-purchase. Yet the evidence is not strong enough and more research with a larger number of participants is needed. There are further additional factors which may complicate the picture, such as total amount of purchased calories or socioeconomic belonging