5 research outputs found
Utilidad de la procalcitonina en el diagnĂłstico de infecciones bacterianas del tracto respiratorio inferior
El objetivo de la revisiĂłn sistemĂĄtica fue determinar la utilidad de la determinaciĂłn in vitro de la PCT en el diagnĂłstico etiolĂłgico de las infecciones del tracto respiratorio inferior. SegĂșn la literatura revisada la PCT parece ser un marcador Ăștil en el diagnĂłstico de las infecciones bacterianas
Cribado neonatal del deficit de biotinidasa
En cubierta aparecen logos del Ministerio de Sanidad, Servicios Sociales e Igualdad, y de la Red Española de Agencias de EvaluaciĂłn de TecnologĂas y Prestaciones del SN
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-Ï auto-Abs in children
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2