Advanced Regenerative Environmental Control and Life Support Systems: Air and Water Regeneration

Extended manned space missions will require regenerative life support techniques. Past manned missions used nonregenerative expendables, except for a molecular sieve based carbon dioxide removal system aboard Skylab. The resupply penalties associated with expendables becomes prohibitive as crew size and mission duration increase. The Space Station scheduled to be operational in the 1990's is based on a crew of four to sixteen and a resupply period of 90 days or greater. It will be the first major spacecraft to employ regenerable techniques for life support. The techniques to be used in the requirements for the space station are addressed

Experimental test on an RC beam equipped with embedded barometric pressure sensors for strains measurement

The current trend in structural health monitoring (SHM) is to install increasingly large numbers of distributed, heterogeneous types of sensors, for a timely and exhaustive detection of any possible damage scenario evolving in the system. These sensors should be low-cost, easy to install, robust and durable. Among others, strain remains one of the most straightforward measurands for monitoring the state of a structural element and for assessing its health condition. However, for application to reinforced concrete structures, currently available strain sensing devices, such as electric strain gauges or fibre optic sensors, do not fully satisfy the aforementioned requirements, generally proving difficult to install, fragile and expensive. In this paper, an innovative monitoring technology, called Smart Steel System (S3), is proposed that measures strains in reinforced concrete members, by incorporating commercial barometric pressure MEMS sensors in appropriate sealed cavities embedded in the reinforcing steel bars. The results of an experimental campaign are reported, in which a reinforced concrete beam, instrumented with both S3 devices and conventional electrical strain gauges, is subjected to increasing loading and unloading cycles until collapse. The tests show the superior robustness of the S3 system during construction and loading as well as its good sensing accuracy, demonstrating its potential for a massive use in SHM applications

Large-Scale Experimental Static Testing on 50-Year-Old Prestressed Concrete Bridge Girders

The heritage of existing road infrastructures and in particular of bridges consists of structures that are approaching or exceeding their designed service life. Detrimental causes such as aging, fatigue and deterioration processes other than variation in loading conditions introduce uncertainties that make structural assessment a challenging task. Experimental data on their performances are crucial for a proper calibration of numerical models able to predict their behavior and life-cycle structural performance. In this scenario, an experimental research program was established with the aim of investigating a set of 50-year-old prestressed concrete bridge girders that were recovered from a decommissioned bridge. The activities included initial non-destructive tests, and then full-scale load tests followed by a destructive test on the material samples. This paper reports the experimental results of the full-scale tests conducted on the first group of four I-beams assumed to be in good condition from visual inspection at the time of testing. Loading tests were performed using a specifically designed steel reaction frame and a test setup equipment, as detailed in the present work. Due to the structural response of this first group of girders, a uniform behavior was found at both service and ultimate conditions. The failure mechanism was characterized by the crushing of the cast-in-situ top slab corresponding to a limited deflection, highlighting a non-ductile behavior. The outcomes of the experimental research are expected to provide new data for the life-cycle safety assessment of existing bridges through an extended database of validated experimental tests and models

Invasive pneumococcal disease in tuscany region, Italy, 2016–2017: Integrating multiple data sources to investigate underreporting

Invasive pneumococcal disease (IPD) is a vaccine-preventable disease characterized by the presence of Streptococcus pneumoniae in normally sterile sites. Since 2007, Italy has implemented an IPD national surveillance system (IPD-NSS). This system suffers from high rates of underreporting. To estimate the level of underreporting of IPD in 2016–2017 in Tuscany (Italy), we integrated data from IPD-NSS and two other regional data sources, i.e., Tuscany regional microbiological surveillance (Microbiological Surveillance and Antibiotic Resistance in Tuscany, SMART) and hospitalization discharge records (HDRs). We collected (1) notifications to IPD-NSS, (2) SMART records positive for S. pneumoniae from normally sterile sites, and (3) hospitalization records with IPD-related International Classification of Diseases, Ninth Revision, Clinical Modification (ICD9) codes in discharge diagnoses. We performed data linkage of the three sources to obtain a combined surveillance system (CSS). Using the CSS, we calculated the completeness of the three sources and performed a three-source log-linear capture–recapture analysis to estimate total IPD underreporting. In total, 127 IPD cases were identified from IPD-NSS, 320 were identified from SMART, and 658 were identified from HDRs. After data linkage, a total of 904 unique cases were detected. The average yearly CSS notification rate was 12.1/100,000 inhabitants. Completeness was 14.0% for IPD-NSS, 35.4% for SMART, and 72.8% for HDRs. The capture–recapture analysis suggested a total estimate of 3419 cases of IPD (95% confidence interval (CI): 1364–5474), corresponding to an underreporting rate of 73.7% (95% CI: 34.0–83.6) for CSS. This study shows substantial underreporting in the Tuscany IPD surveillance system. Integration of available data sources may be a useful approach to complement notification-based surveillance and provide decision-makers with better information to plan effective control strategies against IPD

A nosocomial measles outbreak in Italy, February-April 2017

We describe a nosocomial outbreak of measles that occurred in an Italian hospital during the first months of 2017, involving 35 persons and including healthcare workers, support personnel working in the hospital, visitors and community contacts. Late diagnosis of the first case, support personnel not being promptly recognised as hospital workers and diffusion of the infection in the emergency department had a major role in sustaining this outbreak

MAO A VNTR polymorphism and amygdala volume in healthy subjects

The X-linked Monoamine Oxidase A (MAO A) gene presents a well known functional polymorphism consisting of a variable number of tandem repeats (VNTR) (long and short variants) previously associated with altered neural function of the amygdala. Using automatic subcortical segmentation (Freesurfer), we investigated whether amygdala volume could be influenced by this genotype. We studied 109 healthy subjects (age range 18-80 years; 59 male and 50 female), 74 carrying the MAO A High-activity allele and 35 the MAO A Low-activity allele. No significant effect of the MAO A polymorphism or interaction effect between polymorphism × gender was found on amygdalar volume. Thus, our findings suggest that the reported impact of the MAO A polymorphism on amygdala function is not coupled with consistent volumetric changes in healthy subjects. Future studies are needed to investigate whether the association between volume of the amygdala and the MAO A VNTR polymorphism is influenced by social/psychological variables, such as impulsivity, trauma history and cigarette smoking behaviour, not taken into account in this work