COMPUTATIONAL PREDICTION OF A PROPELLER PERFORMANCE IN OPEN WATER CONDITION

n presence of hydrodynamics phenomena occur surrounding propeller evidently affects on accuracy’s prediction of thrust, torque and its efficiency. To achieve the objective, a Computational Fluid Dynamics (CFD) simulations approach is then proposed to obtain a reliable prediction of the thrust (KT), torque (KQ) and efficiency (η) coefficients in open water condition. The effect of various blade numbers associated with constant propeller revolution (RPM=1320) and pitch ratio (P/D=1.0); are performed within the range of advance ratio from 0.1J1.0. The results revealed that the increase of blade number from Z=3 to 5 was proportional with the increase of thrust (KT) and torque (KQ) coefficients; meanwhile, it was reduced the maximum efficiency (η) that possibly lead to downgrade the propeller performance. It should be noted here, the propeller with three blade numbers (Z=3) provide the highest efficiency (η) up to 78.8% at J=0.9. These CFD simulation results are very useful as a preliminary study of propeller characteristics

The Convergence of Price–cost Margins

Markup, Price–cost margin, Economic integration, L11, L13, L60, F12, F21, E32,

Fluorine-19 nuclear magnetic resonance of chimeric antigen receptor T cell biodistribution in murine cancer model

Abstract Discovery of effective cell therapies against cancer can be accelerated by the adaptation of tools to rapidly quantitate cell biodistribution and survival after delivery. Here, we describe the use of nuclear magnetic resonance (NMR) ‘cytometry’ to quantify the biodistribution of immunotherapeutic T cells in intact tissue samples. In this study, chimeric antigen receptor (CAR) T cells expressing EGFRvIII targeting transgene were labeled with a perfluorocarbon (PFC) emulsion ex vivo and infused into immunocompromised mice bearing subcutaneous human U87 glioblastomas expressing EGFRvIII and luciferase. Intact organs were harvested at day 2, 7 and 14 for whole-sample fluorine-19 (19F) NMR to quantitatively measure the presence of PFC-labeled CAR T cells, followed by histological validation. NMR measurements showed greater CAR T cell homing and persistence in the tumors and spleen compared to untransduced T cells. Tumor growth was monitored with bioluminescence imaging, showing that CAR T cell treatment resulted in significant tumor regression compared to untransduced T cells. Overall, 19F NMR cytometry is a rapid and quantitative method to evaluate cell biodistribution, tumor homing, and fate in preclinical studies