Using the D-BEST Reference Model to Compare Italian and Polish Digital Innovation Hubs

In recent years, the increasing importance of Digital Innovation Hubs (DIHs) in supporting manufacturing Small and Medium Enterprises (SMEs) has been widely studied and several works listing lessons learnt and success stories have been published. To further foster the impact of these entities on the SMEs’ environment, The European Commission has recently introduced the Smart Specialisation Platform, which contains a web service returning to its users a geo-distributed list of DIHs, allowing the user also to cluster and visualise them according to some pre-defined filters, such as the types of technologies employed. The data provided by this platform has been downloaded and a secondary data analysis, based on the websites of the DIHs has been carried on to frame the single DIHs according to the axes of the D-BEST methodology. A comparative analysis with respect to the Italian and Poland situation completes the study, to understand eventual differences and affinities among the two countries

Digital Innovation Hubs Proposing Digital Platforms to Lead the SMEs Digital Transition

DIHs could offer a marketplace and play the role of a broker facilitating cooperation and networking among important stakeholders, harmonizing companies with customers and providing European connections as well. In this framework, DIHs express an increasing need for having platforms bolstering users-producers transactions, fostering to detect what is needed, by grouping a large variety of services and goods together. This paper presents the main platforms grounded on the D-BEST reference model developed by different networks of DIHs. The main characteristics of each of them have been detected and the differences among them unveiled

Abiraterone acetate in metastatic castration-resistant prostate cancer after chemotherapy. A retrospective “Real Life” analysis of activity and safety

Abiraterone acetate (AA) is a potent, selective androge (CYP17) biosynthesis inhibitor, which showed to improve overall survival (HR = 0.646) in mCRPC patients progressing after docetaxel. In this retrospective analysis we assessed the safety and efficacy of AA in patients affected with mCRPC progressing after chemotherapy, treated in the normal clinical practice, in several Italian Oncologic Units, after the approval of the drug from the Italian Drug Agency (AIFA)

Caratterizzazione meccanica delle fasi dell’acciaio Duplex 2205 mediante nanoindentazione

Gli acciai Duplex sono caratterizzati dall’avere una struttura bifasica costituita da austenite e ferrite;le loro proprietà meccaniche dipendono dall’interazione di molti fattori, quali la composizione chimica,la morfologia delle fasi ed il rapporto austenite/ferrite. Quest’ultimo diminuisce all’aumentare dellatemperatura di deformazione. La caratterizzazione meccanica delle due fasi risulta estremamente difficilecon le prove meccaniche tradizionali, le quali forniscono un valor medio e quindi il loro contributo congiunto.Allo scopo di determinare il contributo e le proprietà di ogni singola fase, è stato quindi adoperato un nuovometodo basato sulla tecnica della nanoindentazione. I campioni in Duplex 2205 analizzati, sono statiprecedentemente deformati a caldo a 950, 1000, 1100, 1150 e 1200 °C allo scopo di determinare l’effettodella temperatura di deformazione sulle proprietà meccaniche di ogni singola fase

baseline predictive factors for efficacy of anti pd1 used in first line in melanoma patients an italian melanoma intergroup study

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Systematic vs. on-demand early palliative care in gastric cancer patients: a randomized clinical trial assessing patient and healthcare service outcomes

Purpose: Early palliative care (EPC) has shown a positive impact on quality of life (QoL), quality of care, and healthcare costs. We evaluated such effects in patients with advanced gastric cancer. Methods: In this prospective, multicenter study, 186 advanced gastric cancer patients were randomized 1:1 to receive standard cancer care (SCC) plus on-demand EPC (standard arm) or SCC plus systematic EPC (interventional arm). Primary outcome was a change in QoL between randomization (T0) and T1 (12 weeks after T0) in the Trial Outcome Index (TOI) scores evaluated through the Functional Assessment of Cancer Therapy-Gastric questionnaire. Secondary outcomes were patient mood, overall survival, and family satisfaction with healthcare and care aggressiveness. Results: The mean change in TOI scores from T0 to T1 was − 1.30 (standard deviation (SD) 20.01) for standard arm patients and 1.65 (SD 22.38) for the interventional group, with a difference of 2.95 (95% CI − 4.43 to 10.32) (p = 0.430). The change in mean Gastric Cancer Subscale values for the standard arm was 0.91 (SD 14.14) and 3.19 (SD 15.25) for the interventional group, with a difference of 2.29 (95% CI − 2.80 to 7.38) (p = 0.375). Forty-three percent of patients in the standard arm received EPC. Conclusions: Our results indicated a slight, albeit not significant, benefit from EPC. Findings on EPC studies may be underestimated in the event of suboptimally managed issues: type of intervention, shared decision-making process between oncologists and PC physicians, risk of standard arm contamination, study duration, timeliness of assessment of primary outcomes, timeliness of cohort inception, and recruitment of patients with a significant symptom burden. Clinical trial registration: ClinicalTrials.gov (NCT01996540)

Abiraterone acetate in metastatic castration-resistant prostate cancer after chemotherapy. A retrospective analysis of progression-free (PFS) and overall survival (OS) in the “Real Life”

Background: Abiraterone acetate (AA) is a potent, selective androgen (CYP17) biosynthesis inhibitor, which showed to improve overall survival (HR = 0.646) in mCRPC patients progressing after docetaxel. In this retrospective analysis we assessed the PFS and OS safety in patients affected with mCRPC progressing after chemotherapy, treated in the normal clinical practice, in several Italian Oncologic Units

Looking at NB-IoT over LEO Satellite Systems: Design and Evaluation of a Service-Oriented Solution

The adoption of the NB-IoT technology in satellite communications intends to boost Internet of Things services beyond the boundaries imposed by the current terrestrial infrastructures. Apart from link-level studies in the scientific literature and preliminary 3GPP technical reports, the overall debate is still open. To provide a further step forward in this direction, the work presented herein pursues a novel service-oriented methodology to design an effective solution, meticulously stitched around application requirements and technological constraints. To this end, it conducts link-level and system-level investigations to tune physical transmissions, satellite constellation, and protocol architecture, while ensuring the expected system behavior. To offer a real smart agriculture service operating in Europe, the resulting solution exploits 24 Low Earth Orbit satellites, grouped into 8 different orbits, moving at an altitude of 500 km. The configured protocol stack supports the transmission of tens of bytes generated at the application layer, by also counteracting the issues introduced by the satellite link. Since each satellite has the whole protocol stack on-board, terminals can transmit data without the need for the feeder link. This ensures communication latencies ranging from 16 minutes to 75 minutes, depending on the served number of terminals and the physical transmission settings. Moreover, the usage of the Early Data Transmission scheme reduces communication latencies up to 40%. These results pave the way towards the deployment of an effective proof-of-concept, which drastically reduces the time-to-market imposed by the current state of the art

Design of a CZT Gamma-Camera for GRB and Fast Transient Follow-up: a Wide-Field-Monitor for the EDGE Mission

The success of the SWIFT/BAT and INTEGRAL missions has definitely opened a new window for follow-up and deep study of the transient gamma-ray sky. This now appears as the access key to important progresses in the area of cosmological research and deep understanding of the physics of compact objects. To detect in near real-time explosive events like Gamma-Ray bursts, thermonuclear flashes from Neutron Stars and other types of X-ray outbursts we have developed a concept for a wide-field gamma-ray coded mask instrument working in the range 8-200 keV, having a sensitivity of 0.4 ph cm-2 s-1 in 1s (15-150 keV) and arcmin location accuracy over a sky region as wide as 3sr. This scientific requirement can be achieved by means of two large area, high spatial resolution CZT detection planes made of arrays of relatively large (~1cm2) crystals, which are in turn read out as matrices of smaller pixels. To achieve such a wide Field-Of-View the two units can be placed at the sides of a S/C platform serving a payload with a complex of powerful X-ray instruments, as designed for the EDGE mission. The two units will be equipped with powerful signal read out system and data handling electronics, providing accurate on-board reconstruction of the source positions for fast, autonomous target acquisition by the X-ray telescopes.Comment: 9 pages, 7 figures, SPIE Conference on UV, X-ray, and Gamma-Ray Instrumentation for Astronomy, San Diego 26-30 August 200

Entrepreneurs, Chance, and the Deterministic Concentration of Wealth

In many economies, wealth is strikingly concentrated. Entrepreneurs–individuals with ownership in for-profit enterprises–comprise a large portion of the wealthiest individuals, and their behavior may help explain patterns in the national distribution of wealth. Entrepreneurs are less diversified and more heavily invested in their own companies than is commonly assumed in economic models. We present an intentionally simplified individual-based model of wealth generation among entrepreneurs to assess the role of chance and determinism in the distribution of wealth. We demonstrate that chance alone, combined with the deterministic effects of compounding returns, can lead to unlimited concentration of wealth, such that the percentage of all wealth owned by a few entrepreneurs eventually approaches 100%. Specifically, concentration of wealth results when the rate of return on investment varies by entrepreneur and by time. This result is robust to inclusion of realities such as differing skill among entrepreneurs. The most likely overall growth rate of the economy decreases as businesses become less diverse, suggesting that high concentrations of wealth may adversely affect a country's economic growth. We show that a tax on large inherited fortunes, applied to a small portion of the most fortunate in the population, can efficiently arrest the concentration of wealth at intermediate levels