A novel hepatitis C virus (HCV) subtype from Somalia and its classification into HCV clade 3.

Hepatitis C virus (HCV) sequences from throughout the world have been grouped into six clades, based on recently proposed criteria. Here, the partial sequences and clade assignment are reported for three HCV isolates from chronic hepatitis C patients from Somalia, for whom conventional assays failed to identify the genotype. Phylogenetic analysis of the sequences of the core, envelope 1 and part of the non- structural 5b regions suggests that all three isolates belong to a distinct HCV genetic group, tentatively classified as subtype 3h. This novel HCV subtype shows the highest sequence similarity with HCV isolates from Indonesia. Despite the fact that these patients were infected with HCV clade 3, none of them responded to standard interferon treatment

Lack of in vivo blockade of Fas- and TNFR1-mediated hepatocyte apoptosis by the hepatitis C virus.

In vitro data have shown that the hepatitis C virus (HCV) core protein binds to protein members of the tumour necrosis factor receptor (TNFR) superfamily. Since this interaction could be relevant to HCV persistence and oncogenesis, this study assessed whether HCV may interfere with the apoptotic cascade in vivo. Apoptosis (by TUNEL) and Fas and TNFR1 expression (by immunohistochemistry) were scored in the liver of 60 chronic hepatitis C patients. Results were compared with the liver disease grading and staging scores and the HCV replication level in serum and liver. Apoptotic hepatocytes were stained in 29 cases. Fas was expressed in 35 cases and TNFR1 in 21, 15 patients (25%) being negative for both receptors. Overall, the numbers of TUNEL-, Fas- and TNFR-positive hepatocytes did not correlate with the extent of intrahepatic CD8+ T-lymphocyte infiltration, the grading and staging of liver disease, or the serum or liver HCV RNA levels. Furthermore, when patients expressing either Fas or TNFR1 were stratified according to serum HCV RNA levels, cases with detectable hepatocyte apoptosis had higher HCV viraemias. In conclusion, an HCV-mediated, in vivo blockade of hepatocyte apoptosis via the Fas- or TNFR1-dependent pathways seems unlikely

Slavnov-Taylor Parameterization for the Quantum Restoration of BRST Symmetries in Anomaly-Free Gauge Theories

It is shown that the problem of the recursive restoration of the Slavnov-Taylor (ST) identities at the quantum level for anomaly-free gauge theories is equivalent to the problem of parameterizing the local approximation to the quantum effective action in terms of ST functionals, associated with the cohomology classes of the classical linearized ST operator. The ST functionals of dimension <=4 correspond to the invariant counterterms, those of dimension >4 generate the non-symmetric counterterms upon projection on the action-like sector. At orders higher than one in the loop expansion there are additional contributions to the non-invariant counterterms, arising from known lower order terms. They can also be parameterized by using the ST functionals. We apply the method to Yang-Mills theory in the Landau gauge with an explicit mass term introduced in a BRST-invariant way via a BRST doublet. Despite being non-unitary, this model provides a good example where the method devised in the paper can be applied to derive the most general solution for the action-like part of the quantum effective action, compatible with the fulfillment of the ST identities and the other relevant symmetries of the model, to all orders in the loop expansion. The full dependence of the solution on the normalization conditions is given.Comment: 23 pages. Final version published in the journa

The Role of Bulge Formation in the Homogenization of Stellar Populations at z∼2z\sim2 as revealed by Internal Color Dispersion in CANDELS

We use data from the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey to study how the spatial variation in the stellar populations of galaxies relate to the formation of galaxies at $1.5 < z < 3.5$. We use the Internal Color Dispersion (ICD), measured between the rest-frame UV and optical bands, which is sensitive to age (and dust attenuation) variations in stellar populations. The ICD shows a relation with the stellar masses and morphologies of the galaxies. Galaxies with the largest variation in their stellar populations as evidenced by high ICD have disk-dominated morphologies (with S\'{e}rsic indexes $< 2$) and stellar masses between $10 < \mathrm{Log~M/ M_\odot}< 11$. There is a marked decrease in the ICD as the stellar mass and/or the S\'ersic index increases. By studying the relations between the ICD and other galaxy properties including sizes, total colors, star-formation rate, and dust attenuation, we conclude that the largest variations in stellar populations occur in galaxies where the light from newly, high star-forming clumps contrasts older stellar disk populations. This phase reaches a peak for galaxies only with a specific stellar mass range, $10 < \mathrm{Log~M/ M_\odot} < 11$, and prior to the formation of a substantial bulge/spheroid. In contrast, galaxies at higher or lower stellar masses, and/or higher S\'{e}rsic index ($n > 2$) show reduced ICD values, implying a greater homogeneity of their stellar populations. This indicates that if a galaxy is to have both a quiescent bulge along with a star forming disk, typical of Hubble Sequence galaxies, this is most common for stellar masses $10 < \mathrm{Log~M/M_\odot} < 11$ and when the bulge component remains relatively small ($n<2$).Comment: 15 pages, 14 figure

CLEAR I: Ages and Metallicities of Quiescent Galaxies at 1.0<z<1.8\mathbf{1.0 < z < 1.8} Derived from Deep Hubble Space Telescope Grism Data

We use deep \textit{Hubble Space Telescope} spectroscopy to constrain the metallicities and (\editone{light-weighted}) ages of massive ($\log M_\ast/M_\odot\gtrsim10$) galaxies selected to have quiescent stellar populations at $1.0<z<1.8$. The data include 12--orbit depth coverage with the WFC3/G102 grism covering $\sim$ $8,000<\lambda<11,500$~\AA\, at a spectral resolution of $R\sim 210$ taken as part of the CANDELS Lyman-$\alpha$ Emission at Reionization (CLEAR) survey. At $1.0<z<1.8$, the spectra cover important stellar population features in the rest-frame optical. We simulate a suite of stellar population models at the grism resolution, fit these to the data for each galaxy, and derive posterior likelihood distributions for metallicity and age. We stack the posteriors for subgroups of galaxies in different redshift ranges that include different combinations of stellar absorption features. Our results give \editone{light-weighted ages of $t_{z \sim 1.1}= 3.2\pm 0.7$~Gyr, $t_{z \sim 1.2}= 2.2\pm 0.6$~Gyr, $t_{z\sim1.3}= 3.1\pm 0.6$~Gyr, and $t_{z\sim1.6}= 2.0 \pm 0.6$~Gyr, \editone{for galaxies at $z\sim 1.1$, 1.2, 1.3, and 1.6. This} implies that most of the massive quiescent galaxies at $168$\% of their stellar mass by a redshift of $z>2$}. The posteriors give metallicities of \editone{$Z_{z\sim1.1}=1.16 \pm 0.29$~$Z_\odot$, $Z_{z\sim1.2}=1.05 \pm 0.34$~$Z_\odot$, $Z_{z\sim1.3}=1.00 \pm 0.31$~$Z_\odot$, and $Z_{z\sim1.6}=0.95 \pm 0.39$~$Z_\odot$}. This is evidence that massive galaxies had enriched rapidly to approximately Solar metallicities as early as $z\sim3$.Comment: 32 pages, 23 figures, Resubmited to ApJ after revisions in response to referee repor

An Approach to the Equivalence Theorem by the Slavnov-Taylor Identities

We discuss the Equivalence Theorem (ET) in the BRST formalism. The existence of a local inverse of the field transformation (at least as a formal power expansion) suggests a formulation of the ET, which allows a nilpotent BRST symmetry. This strategy cannot be implemented at the quantum level if the inverse is non-local. In this case we propose an alternative formulation of the ET, where, by using Faddeev-Popov fields, this difficulty is circumvented. We study the quantum deformation of the associated ST identity, which turns out to be anomaly free, and show that a selected set of Green functions, which in some cases can be identified with the physical observables of the model, does not depend on the choice of the transformation of the fields. In general the transformation of the fields yields a non-renormalizable theory. When the equivalence is established between a renormalizable and a non-renormalizable theory, the ET provides a way to give a meaning to the last one by using the resulting ST identity. In this case the Quantum Action Principle cannot be of any help in the discussion of the ET. We assume and discuss the validity of a Quasi Classical Action Principle, which turns out to be sufficient for the present work. As an example we study the renormalizability and unitarity of massive QED in Proca's gauge by starting from a linear Lorentz-covariant gauge.Comment: 26 page