Additional file 1 of MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib

Supplementary Material

Additional file 1: of MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma

Figure S1. Modulation of CITED2 or UPF1 mimics miR-1468-induced cellular processes in HCC. (A) Hep3B-miR-control cells that were transfected with empty vector (EV) or CITED2, UPF1 overexpression plasmid were subjected to western blot for CITED2 and UPF1. MHCC-97 L-anti-miR-NC cells that were transfected with scrambled siRNA or CITED2, UPF1 siRNA were subjected to western blot for CITED2, UPF1. CITED2 or UPF1 restoration mimics the effects of miR-1468 knockdown on cell proliferation (B, C), colony formation (D), cell cycle progression (E) and apoptosis (F) of Hep3B cells. CITED2 or UPF1 knockdown mimics effects of miR-1468 overexpression in MHCC-97 L cells (B-F). (G) Alteration of CITED2 or UPF1 mimics the effects of miR-1468 on cell cycle and apoptosis associated factors. *P < 0.05. (TIFF 704 kb

Additional file 1: Figure S1. of MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway

miR-1296 suppresses EMT process of HCC cells. (A) HCCLM3 cells that were transfected with miR-1296 and miR-control, respectively, were subjected to immunoblotting for the expression of EMT-related markers including ZO-1, ZEB-1, Slug, Snail and Twist. (B) miR-1296 knockdown decreased ZO-1 expression and increased the levels of ZEB-1, Slug, Snail and Twist in Hep3B cells. *P < 0.05. (TIFF 258 kb

El Diario de Pontevedra : periódico liberal: Ano XV Número 4109 - 1898 abril 4

IHC staining of E-cadherin, Vimentin and SRPK1 in HCC tissues. Representative IHC results indicated that strong staining of E-cadherin and weak staining of Vimentin and SRPK1 were observed in miR-1296 high-expressing HCC tissue. Weak staining of E-cadherin and strong staining of Vimentin and SRPK1 were presented in miR-1296 low-expressing HCC tissues. (TIFF 2252 kb

Additional file 3: of MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma

Figure S3. Overview of miR-1468-induced tumor progression and activates PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma. (TIFF 77 kb

Additional file 3: Figure S2. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

HSP90 inhibitors reduced the protein level of PKM2. Hep3B cells were treated with 17-AAG and 17-DMAG, two kinds of HSP90 inhibitors. HSP90 inhibitors decreased PKM2 protein in Hep3B cells. (TIFF 2886 kb

La Prospérité : journal mensuel d'hygiène générale et d'économie domestique : paraissant le 15 de chaque mois

janvier 18991899/01 (A4)