2,577 research outputs found
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Virtual Simulation for Multi-material LM Process
In an ONR funded MURI program, to improve quality of multi-material parts,
we've been developing an advanced computer simulation for the multi-material layered
manufacturing (LM) process. The CAD models and their .stLfiles are created using. the
commercially available software such as I-DEAS and ProE. Using this information, one
tool path file per material is generated. Our file preparation algorithm, systematically,
layer by layer, integrates all tool path files into one multi-material tool path file. The
results of the multi-material tool path are graphically visualized using the simulation
algorithm (written in c++ & SGI OpenGL). From a virtual simulation, we can check the
LM process, and make the best selection of tool path parameters afterwards. After several
trials from design to simulation, if the simulation result is acceptable, the real
manufacturing can be started. And the part's quality should be better than a part
manufactured without running simulation in advance. This paper will represent .•. new
studies on using real toadshapes to get more realistic simulation results. Many parts have
been successfully simulated using our method.Mechanical Engineerin
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A New Feature in an Extrusion Based LM Process – Adaptive Roadwidth 399
For extrusion based LM processes, a computational based adaptive roadwidth algorithm have been developed which further reduces (if not eliminate) all voids and defects. Toolpath equations are written in terms of roadwidth, vector path offset, subperimeter offset, and vector angles. The program computes all contours and vector paths to fill a layer, the location and size of all voids/defects, and makes comparison with the acceptable void limits. Based on this information, the adaptive roadwidth for the vector paths are then created to minimize the voids and defects. This new feature is added to the existing in-house multi-material LM CAD software.Mechanical Engineerin
A Rare Root Canal Configuration of a Maxillary Second Molar with Fused C-shaped Buccal Root and Five Canals: A Case Report and Review of literature
Having a thorough knowledge of root canal configuration is essential for a successful endodontic treatment. Clinicians should always pay attention to the unusual canal configuration so as to avoid missing extra canals. This paper describes a non-surgical retreatment of a maxillary second molar with two missing root canals; diagnosed by cone-beam computed tomographic (CBCT) imaging. The tooth had three roots and five canals: a C-shaped buccal root fused by mesiobuccal (MB) and distobuccal (DB) roots with three canals (CBCT scanning showed that the second MB canal was closer to the palatal than the buccal side), a mesiopalatal root with one canal, and a distopalatal root with one canal. The purpose of this case report is to remind clinicians of the importance of anatomical variations, and thus, detection of extra canals.Keywords: Maxillary Second Molar; C-shaped Canal; Cone-Beam Computed Tomograph
A role of corazonin receptor in larval-pupal transition and pupariation in the oriental fruit fly Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)
Corazonin (Crz) is a neuropeptide hormone, but also a neuropeptide modulator that is internally released within the CNS, and it has a widespread distribution in insects with diverse physiological functions. Here, we identified and cloned the cDNAs of Bactrocera dorsalis that encode Crz and its receptor CrzR. Mature BdCrz has 11 residues with a unique Ser11 substitution (instead of the typical Asn) and a His in the evolutionary variable position 7. The BdCrzR cDNA encodes a putative protein of 608 amino acids with 7 putative transmembrane domains, typical for the structure of G-protein-coupled receptors. When expressed in Chinese hamster ovary (CHO) cells, the BdCrzR exhibited a high sensitivity and selectivity for Crz (EC50 approximate to 52.5 nM). With qPCR, the developmental stage and tissue-specific expression profiles in B. dorsalis demonstrated that both BdCrz and BdCrzR were highly expressed in the larval stage, and BdCrzR peaked in 2-day-old 3rd-instar larvae, suggesting that the BdCrzR may play an important role in the larval-pupal transition behavior. Immunochemical localization confirmed the production of Crz in the central nervous system (CNS), specifically by a group of three neurons in the dorso-lateral protocerebrum and eight pairs of lateral neurons in the ventral nerve cord. qPCR analysis located the BdCrzR in both the CNS and epitracheal gland, containing the Inka cells. Importantly, dsRNA-BdCrzR-mediated gene-silencing caused a delay in larval-pupal transition and pupariation, and this phenomenon agreed with a delayed expression of tyrosine hydroxylase and dopa-decarboxylase genes. We speculate that CrzR-silencing blocked dopamine synthesis, resulting in the inhibition of pupariation and cuticular melanization. Finally, injection of Crz in head-ligated larvae could rescue the effects. These findings provide a new insight into the roles of Crz signaling pathway components in B. dorsalis and support an important role of CrzR in larval-pupal transition and pupariation behavior
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