CFD Simulations to Study Parameters Affecting Gas Explosion Venting in Compressor Compartments

In this work, a series of vented explosions in a typical compressor compartment are simulated using FLACS code to analyze the explosion venting characteristics. The effects of relevant parameters on the pressure peaks (i.e., overpressure and negative pressure) are also numerically investigated, including vent area ratio of the compressor compartment, vent activation pressure, mass per unit area of vent panels, and volume blockage ratio of obstacles. In addition, the orthogonal experiment design and improved grey relational analysis are implemented to evaluate the impact degree of these relevant parameters. The results show that the pressure peaks decrease with the increase of vent area ratio. There is an approximately linearly increasing relationship between the pressure peaks and the vent activation pressure. The pressure peaks increase with the mass per unit area of vent panels. The pressure peaks increase with the volume blockage ratio of obstacles. Based on the grey relational grade values, the effects of these relevant parameters on the overpressure peak are ranked as follows: volume blockage ratio of obstacles > vent activation pressure > vent area ratio > mass per unit area of vent panels. These achievements provide effective guidance for the venting safety design of gas compressor compartments

FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs

FurinDB (freely available online at http://www.nuolan.net/substrates.html) is a database of furin substrates. This database includes experimentally verified furin cleavage sites, substrates, species, experimental methods, original publications of experiments and associated drugs targeting furin substrates. The current database release contains 126 furin cleavage sites from three species: mammals, bacteria and viruses. A main feature of this database is that all furin cleavage sites are recorded as a 20-residue motif, including one core region (eight amino acids, P6–P2′) and two flanking solvent accessible regions (eight amino acids, P7–P14, and four amino acids, P3′–P6′), that represent our current understanding of the molecular biology of furin cleavage. This database is important for understanding the molecular evolution and relationships between sequence motifs, 3D structures, cellular functions and physical properties required by furin for cleavage, and for elucidating the molecular mechanisms and the progression of furin cleavage associated human diseases, including pathogenic infections, neurological disorders, tumorigenesis, tumor invasion, angiogenesis, and metastasis. FurinDB database will be a solid addition to the publicly available infrastructure for scientists in the field of molecular biology

Effects of EGR rates on combustion and emission characteristics in a diesel engine with n-butanol/PODE3-4/diesel blends

An experimental investigation is conducted on the influence of EGR (Exhaust Gas Recirculation) rates (0–40%) on the combustion and emission characteristics of n-butanol/diesel/PODE3-4 blends at low-temperature combustion mode in diesel engine. The results show that at identical EGR rate, compared to D100 (diesel fuel), the peak values both of the mean cylinder pressure and the heat release rate of BD20 (20% butanol and 80% diesel in volume) are increased, ignition delay is extended, and the brake thermal efficiency is enhanced. Concerning BD20 blended with PODE3-4, the ignition delay is shortened, while both the brake thermal efficiency and the combustion efficiency increase. At the EGR rate below 30%, as the EGR rate grows, the effects on emission of soot, CO and HC are not significant, while the emission of NOx is sharply reduced; when the EGR rate is above 30%, as it grows, the emissions of soot, CO, and HC drastically rise. As EGR rate grows, the total particulate matter (PM) number concentrations of four fuels firstly decline and then rise, the total PM mass concentrations keep stable firstly and then rise drastically. As the proportion of added PODE3-4 in BD20 grows, the particle geometric mean diameters further decrease

A Trend-Switching Financial Time Series Model with Level-Duration Dependence

The financial time series model that can capture the nonlinearity and asymmetry of stochastic process has been paid close attention for a long time. However, it is still open to completely overcome the difficult problem that motivates our researches in this paper. An asymmetric and nonlinear model with the change of local trend depending on local high-low turning point process is first proposed in this paper. As the point process can be decomposed into the two different processes, a high-low level process and an up-down duration process, we then establish the so-called trend-switching model which depends on both level and duration (Trend-LD). The proposed model can predict efficiently the direction and magnitude of the local trend of a time series by incorporating the local high-low turning point information. The numerical results on six indices in world stock markets show that the proposed Trend-LD model is suitable for fitting the market data and able to outperform the traditional random walk model

beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL

<p>Abstract</p> <p>Background</p> <p>Female hormones are known to play an important role in predisposition for many infectious diseases. Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone β-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T).</p> <p>Results</p> <p>Human PBL were infected with HIV-1 in the presence or absence of combinations of sex steroid hormones and the anti-retroviral drug, D4T. After seven days in culture, viral supernatants were assayed for HIV-1 p24 protein. β-estradiol resulted in a modest inhibition of HIV-1 replication of ~26%. However, 2 nM β-estradiol increased the amount of HIV-1 replication in the presence of 50 nM D4T from a baseline of 33% (+/- SE = 5.4) to 74% (+/- SE = 5.4) of control virus levels in the absence of drug. Both results were statistically highly significant (p < 0.001). β-estradiol did not increase the replication of a D4T-resistant strain of HIV in the presence of D4T. The effects were unlikely to be due to general cell inhibition or toxicity because these concentrations of drug and hormone cause no cytotoxicity in PBL as measured by trypan blue exclusion.</p> <p>Conclusion</p> <p>β-estradiol inhibited both HIV-1 replication in primary human PBL and the antiretroviral efficacy of D4T in PBL cultures. To optimize antiretroviral drug therapy, it may be necessary to monitor patient hormonal status.</p

Layer- and Direction-Specific Material Properties, Extreme Extensibility and Ultimate Material Strength of Human Abdominal Aorta and Aneurysm: A Uniaxial Extension Study.

Mechanical analysis has the potential to provide complementary information to aneurysm morphology in assessing its vulnerability. Reliable calculations require accurate material properties of individual aneurysmal components. Quantification of extreme extensibility and ultimate material strength of the tissue are important if rupture is to be modelled. Tissue pieces from 11 abdomen aortic aneurysm (AAA) from patients scheduled for elective surgery and from 8 normal aortic artery (NAA) from patients who scheduled for kidney/liver transplant were collected at surgery and banked in liquid nitrogen with the use of Cryoprotectant solution to minimize frozen damage. Prior to testing, specimen were thawed and longitudinal and circumferential tissue strips were cut from each piece and adventitia, media and thrombus if presented were isolated for the material test. The incremental Young's modulus of adventitia of NAA was direction-dependent at low stretch levels, but not the media. Both adventitia and media had a similar extreme extensibility in the circumferential direction, but the adventitia was much stronger. For aneurysmal tissues, no significant differences were found when the incremental moduli of adventitia, media or thrombus in both directions were compared. Adventitia and media from AAA had similar extreme extensibility and ultimate strength in both directions and thrombus was the weakest material. Adventitia and media from AAA were less extensible compared with those of NAA, but the ultimate strength remained similar. The material properties, including extreme extensibility and ultimate strength, of both healthy aortic and aneurysmal tissues were layer-dependent, but not direction-dependent.This research is supported by BHF PG/11/74/ 29100, HRUK RG2638/14/16, the NIHR Cambridge Biomedical Research Centre, and National Natural Science Foundation of China (81170291).This is the final version. It was first published by Springer at http://dx.doi.org/10.1007/s10439-015-1323-

A uni-extension study on the ultimate material strength and extreme extensibility of atherosclerotic tissue in human carotid plaques.

Atherosclerotic plaque rupture occurs when mechanical loading exceeds its material strength. Mechanical analysis has been shown to be complementary to the morphology and composition for assessing vulnerability. However, strength and stretch thresholds for mechanics-based assessment are currently lacking. This study aims to quantify the ultimate material strength and extreme extensibility of atherosclerotic components from human carotid plaques. Tissue strips of fibrous cap, media, lipid core and intraplaque hemorrhage/thrombus were obtained from 21 carotid endarterectomy samples of symptomatic patients. Uni-extension test with tissue strips was performed until they broke or slid. The Cauchy stress and stretch ratio at the peak loading of strips broken about 2mm away from the clamp were used to characterize their ultimate strength and extensibility. Results obtained indicated that ultimate strength of fibrous cap and media were 158.3 [72.1, 259.3] kPa (Median [Inter quartile range]) and 247.6 [169.0, 419.9] kPa, respectively; those of lipid and intraplaque hemorrhage/thrombus were 68.8 [48.5, 86.6] kPa and 83.0 [52.1, 124.9] kPa, respectively. The extensibility of each tissue type were: fibrous cap - 1.18 [1.10, 1.27]; media - 1.21 [1.17, 1.32]; lipid - 1.25 [1.11, 1.30] and intraplaque hemorrhage/thrombus - 1.20 [1.17, 1.44]. Overall, the strength of fibrous cap and media were comparable and so were lipid and intraplaque hemorrhage/thrombus. Both fibrous cap and media were significantly stronger than either lipid or intraplaque hemorrhage/thrombus. All atherosclerotic components had similar extensibility. Moreover, fibrous cap strength in the proximal region (closer to the heart) was lower than that of the distal. These results are helpful in understanding the material behavior of atherosclerotic plaques.This research is supported by BHF PG/11/74/29100, HRUK RG2638/14/16, the NIHR Cambridge Biomedical Research Centre and National Natural Science Foundation of China (81170291).This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.jbiomech.2015.09.03

Nickel hydroxide-supported ru single atoms and Pd nanoclusters for enhanced electrocatalytic hydrogen evolution and ethanol oxidation

The rational fabrication of Pt-free catalysts for driving the development of practical applications in alkaline water electrolysis and fuel cells is promising but challenging. Herein, a promising approach is outlined for the rational design of multimetallic catalysts comprising multiple active sites including Pd nanoclusters and Ru single atoms anchored at the defective sites of Ni(OH)2 to simultaneously enhance hydrogen evolution reactions (HER) and ethanol oxidation reactions (EOR). Remarkably, Pd12Ru3/Ni(OH)2/C exhibits a remarkably reduced HER overpotential (16.1 mV@10 mA cm−2 with a Tafel slope of 21.8 mV dec−1) as compared to commercial 20 wt.% Pt/C (26.0 mV@10 mA cm−2, 32.5 mV dec−1). More importantly, Pd12Ru3/Ni(OH)2/C possesses a self-optimized overpotential to 12.5 mV@10 mA cm−2 after 20 000 cycles stability test while a significantly decreased performance for commercial 20wt.% Pt/C (64.5 mV@10 mA cm−2 after 5000 cycles). The mass activity of Pd12Ru3/Ni(OH)2/C for the EOR is up to 3.724 A mgPdRu−1, ≈20 times higher than that of commercial Pd/C. Electrochemical in situ Fourier transform infrared measurements confirm the enhanced CO2 selectivity of Pd12Ru3/Ni(OH)2/C while synergistic and electronic effects of adjacent Ru, Pd, and OHad adsorption on Ni(OH)2 at low potential play a key role during EOR