698 research outputs found
Comment on 'Note on the dog-and-rabbit chase problem in introductory kinematics'
We comment on the recent paper by Yuan Qing-Xin and Du Yin-Xiao (Eur. J.
Phys. 29 (2008) N43-N45).Comment: 2 pages, no figure
The aggregation rate constant of the discrete population balance model in hot melt fluidized bed coating process
[EN] During hot melt fluidized bed coating, particle agglomeration leads to non-uniform particle size. In this study, Population Balance Model (PBM) is used to establish the conservation of the size of particles in the system. In order to solve the population balance model, it is discretized. The aggregation kernel of the particles can be described by the Equi-partition of Kinetic Energy (EKE) kernel based on the gas dynamics theory. The EKE kernel is incorporated into a discrete population balance (DPB) model, and the effective aggregation rate constant is obtained by fitting with the experimental data.The authors acknowledge Projects supported by the National Natural Science Foundation of China (Grant No.21506163 & No. 31571906).Xin, W.; Yan, Y.; Qing, X.; Long, W. (2018). The aggregation rate constant of the discrete population balance model in hot melt fluidized bed coating process. En IDS 2018. 21st International Drying Symposium Proceedings. Editorial Universitat Politècnica de València. 473-480. https://doi.org/10.4995/IDS2018.2018.7726OCS47348
Rotational Symmetry of Classical Orbits, Arbitrary Quantization of Angular Momentum and the Role of Gauge Field in Two-Dimensional Space
We study the quantum-classical correspondence in terms of coherent wave
functions of a charged particle in two-dimensional central-scalar-potentials as
well as the gauge field of a magnetic flux in the sense that the probability
clouds of wave functions are well localized on classical orbits. For both
closed and open classical orbits, the non-integer angular-momentum quantization
with the level-space of angular momentum being greater or less than is
determined uniquely by the same rotational symmetry of classical orbits and
probability clouds of coherent wave functions, which is not necessarily
-periodic. The gauge potential of a magnetic flux impenetrable to the
particle cannot change the quantization rule but is able to shift the spectrum
of canonical angular momentum by a flux-dependent value, which results in a
common topological phase for all wave functions in the given model. The quantum
mechanical model of anyon proposed by Wilczek (Phys. Rev. Lette. 48, 1144)
becomes a special case of the arbitrary-quantization.Comment: 6 pages, 5 figure
Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis
__Background:__ Numerous epidemiological studies have examined associations of genetic variations in LEP (G2548A, -2548 nucleotide upstream of the ATG start site) and LEPR (Q223R, nonsynonymous SNP in exon 6) with cancer susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate such associations.
__Methods:__ We searched published literature from MEDLINE, EMBASE, Web of Science and CBM for eligible publications. We also assessed genotype-based mRNA expression data from HapMap for rs7799039 (G2548A) and rs1137101 (Q223R) in normal cell lines derived from 270 subjects with different ethnicities.
__Results:__ The final analysis included 16 published studies of 6569 cases and 8405 controls for the LEP G2548A and 19 studies of 7504 cases and 9581 controls for the LEPR Q223R. Overall, LEP G2548A was statistically significantly associated with an increased risk of overall cancer (AA vs. GG: OR=1.27, 95% CI=1.05-1.54; recessive model: OR=1.19, 9
Parallel momentum distribution of the Si fragments from P
Distribution of the parallel momentum of Si fragments from the breakup
of 30.7 MeV/nucleon P has been measured on C targets. The distribution
has the FWHM with the value of 110.5 23.5 MeV/c which is consistent
quantitatively with Galuber model calculation assuming by a valence proton in
P. The density distribution is also predicted by Skyrme-Hartree-Fock
calculation. Results show that there might exist the proton-skin structure in
P.Comment: 4 pages, 4 figure
Leveraging Large Language Models for Pre-trained Recommender Systems
Recent advancements in recommendation systems have shifted towards more
comprehensive and personalized recommendations by utilizing large language
models (LLM). However, effectively integrating LLM's commonsense knowledge and
reasoning abilities into recommendation systems remains a challenging problem.
In this paper, we propose RecSysLLM, a novel pre-trained recommendation model
based on LLMs. RecSysLLM retains LLM reasoning and knowledge while integrating
recommendation domain knowledge through unique designs of data, training, and
inference. This allows RecSysLLM to leverage LLMs' capabilities for
recommendation tasks in an efficient, unified framework. We demonstrate the
effectiveness of RecSysLLM on benchmarks and real-world scenarios. RecSysLLM
provides a promising approach to developing unified recommendation systems by
fully exploiting the power of pre-trained language models.Comment: 13 pages, 4 figure
An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer
Advanced prostate cancer displays conspicuous chromosomal instability and rampant copy number aberrations, yet the identity of functional drivers resident in many amplicons remain elusive. Here, we implemented a functional genomics approach to identify new oncogenes involved in prostate cancer progression. Through integrated analyses of focal amplicons in large prostate cancer genomic and transcriptomic datasets as well as genes upregulated in metastasis, 276 putative oncogenes were enlisted into an in vivo gain-of-function tumorigenesis screen. Among the top positive hits, we conducted an in-depth functional analysis on Pygopus family PHD finger 2 (PYGO2), located in the amplicon at 1q21.3. PYGO2 overexpression enhances primary tumor growth and local invasion to draining lymph nodes. Conversely, PYGO2 depletion inhibits prostate cancer cell invasion in vitro and progression of primary tumor and metastasis in vivo In clinical samples, PYGO2 upregulation associated with higher Gleason score and metastasis to lymph nodes and bone. Silencing PYGO2 expression in patient-derived xenograft models impairs tumor progression. Finally, PYGO2 is necessary to enhance the transcriptional activation in response to ligand-induced Wnt/β-catenin signaling. Together, our results indicate that PYGO2 functions as a driver oncogene in the 1q21.3 amplicon and may serve as a potential prognostic biomarker and therapeutic target for metastatic prostate cancer.Significance: Amplification/overexpression of PYGO2 may serve as a biomarker for prostate cancer progression and metastasis. Cancer Res; 78(14); 3823-33. ©2018 AACR
Enhancing Recommender Systems with Large Language Model Reasoning Graphs
Recommendation systems aim to provide users with relevant suggestions, but
often lack interpretability and fail to capture higher-level semantic
relationships between user behaviors and profiles. In this paper, we propose a
novel approach that leverages large language models (LLMs) to construct
personalized reasoning graphs. These graphs link a user's profile and
behavioral sequences through causal and logical inferences, representing the
user's interests in an interpretable way. Our approach, LLM reasoning graphs
(LLMRG), has four components: chained graph reasoning, divergent extension,
self-verification and scoring, and knowledge base self-improvement. The
resulting reasoning graph is encoded using graph neural networks, which serves
as additional input to improve conventional recommender systems, without
requiring extra user or item information. Our approach demonstrates how LLMs
can enable more logical and interpretable recommender systems through
personalized reasoning graphs. LLMRG allows recommendations to benefit from
both engineered recommendation systems and LLM-derived reasoning graphs. We
demonstrate the effectiveness of LLMRG on benchmarks and real-world scenarios
in enhancing base recommendation models.Comment: 12 pages, 6 figure
Opposing roles of TGFβ and BMP signaling in prostate cancer development
SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cancer model. These studies demonstrated that the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis. In contrast, BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression. These analyses reveal the complexity of TGFβ-BMP signaling and illuminate potential therapeutic targets for prostate cancer
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