469 research outputs found
(E)-3-Allylsulfanyl-N-(4-methoxybenzylidene)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine
The title compound, C22H24N4O4S, adopts a trans configuration with respect to the C=N double bond. A weak intramolecular C—H⋯N hydrogen bond is observed between the N atom of the C=N double bond and its neighboring phenyl H atom. The crystal structure is stabilized by intermolecular C—H⋯N hydrogen bonds and C—H⋯π interactions
N-[(E)-2-Chlorobenzylidene]-3-(4-methylbenzylsulfanyl)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine
In the title compound, C26H25ClN4O3S, the acyclic imine group exhibits an E configuration. The triazole ring is oriented at dihedral angles of 53.84 (2), 70.77 (1) and 32.59 (3)° with respect to the benzene rings of the 2-chlorobenzylidene, 4-methylbenzylsulfanyl and 3,4,5-trimethoxyphenyl groups, respectively. The crystal packing is stabilized by weak intermolecular C—H⋯N, C—H⋯S and C—H⋯π interactions
(Z)-Methyl 4-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)-3-oxobutanoate
In the molecular structure of the title compound, C13H12N2O4S2, there is a dihedral angle of 0.41 (13)° between the benzene and thiazole rings. In the crystal, inversion dimers linked by two C—H⋯O interactions together with π–π stacking between the parallel benzene rings of adjacent molecules [centroid–centroid distance = 3.673 (2) Å]
N-[3-(2-Methylphenyl)isoquinolin-1-yl]formamide
The title compound, C17H14N2O, crystallizes as a cis formamide isomer. The isoquinoline and benzene fragments are nearly perpendicular [dihedral angle = 81.79 (18)°], whereas the formamide group is virtually coplanar with the isoquinoline unit [dihedral angle = 1.66 (15)°]. Intermolecular N—H⋯O hydrogen bonds link molecules into a centrosymmetric dimer
Effect of long-term topical latanoprost medication on conjunctival thickness in patients with glaucoma
AIM: To investigate the effect of long-term use of topically administered latanoprost on conjunctival thickness (CT) and conjunctival epithelium thickness (CET) in the patients with glaucoma.
METHODS: A series of 106 glaucomatous patients were included. Of the 106 eyes, 55 eyes were treated with latanoprost eye drops once a day (latanoprost group), while 51 eyes were treated with carteolol hydrochloride eye drops (carteolol group). All the included patients completed a 2-year follow-up. CT and CET were measured with optical coherence tomography (OCT) in all patients at presentation and at 2-year visit, respectively. Statistical analysis was then performed to compare the change in CT and CET.
RESULTS: At presentation, there was no difference in CET (t=0.400, P=0.689) or CT (t=1.14, P=0.259) between the two groups. No significant difference was found in CET (61.65±5.35 μm at baseline, 60.36±6.36 μm at 2-year follow-up, respectively; t=1.977, P=0.0531), while there was a significant decrease in CT from 201.45±14.99 μm at baseline to 167.81±14.57 μm at 2-year visit (t=14.1407, P<0.001) in the latanoprost group. At 2-year follow-up, no statistically difference was found in CET (62.24±5.27 μm; t=1.086, P=0.282) or CT (201.23±12.45 μm; t=1.44, P=0.154) compared to it at baseline (CET: 61.23±5.42 μm; CT: 198.76±13.68 μm, respectively) in the carteolol group.
CONCLUSION: A significant decrease in conjunctival thickness is found in glaucoma patients treated with long-term topical latanoprost; its potential effect on the outcome of filtration surgery should be considered
Фазовий склад та магніторезистивні властивості плівкових системи Ni/Au/Ni
Магнітні багатошарові структури, які останніми роками інтенсивно досліджуються, важливі як з точки зору теоретичних досліджень, так і для практичного застосування. Прикладний інтерес викликаний їх
здатністю поєднувати у собі властивості магнітом’яких і магнітотвердих матеріалів, які суттєво залежать від структури і фазового складуз разків.У даній роботі, в якості досліджуваних магнітних структур, було
використано тришарові плівкові системи Ni(d) / Au(15 нм) / Ni(25 нм) отримані шляхом пошарової конденсації, де d – товщина верхнього шару Ni, яка змінювалась від 5 до 15 нм
Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2
Reactive oxygen species (ROS) are closely related to the follicular granulosa cell apoptosis. Grape seed procyanidin B2 (GSPB2) has been reported to possess potent antioxidant activity. However, the GSPB2-mediated protective effects and the underlying molecular mechanisms in granulosa cell apoptosis process remain unknown. In this study, we showed for the first time that GSPB2 treatment decreased FoxO1 protein level, improved granulosa cell viability, upregulated LC3-II protein level, and reduced granulosa cell apoptosis rate. Under a condition of oxidative stress, GSPB2 reversed FoxO1 nuclear localization and increased its level in cytoplasm. In addition, FoxO1 knockdown inhibited the protective effects of GSPB2 induced. Our findings suggest that FoxO1 plays a pivotal role in regulating autophagy in granulosa cells, GSPB2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducing autophagy process, and targeting FoxO1 could be significant in fighting against oxidative stress-reduced female reproductive system diseases
A Simplified Rice DNA Extraction Protocol for PCR Analysis
Abstract: A simple protocol was established for DNA extraction using etiolated rice seedlings, whereby rice DNA was directly extracted in 0.5 mol/L NaOH solution in a single eppendorf tube. Results of comparative PCR analyses and electrophoresis showed that the DNA extracted using this method was as good and useful as that using standard CTAB method. Key words: DNA extraction; rice; polymerase chain reaction; molecular marker; simple sequence repeats; transgene DNA molecular marker technology has been advancing rapidly during past decades and its application perspective seems very brilliant in crop breeding, varietal purity test of crop seeds and germplasm fingerprinting MATERIALS AND METHODS Materials Seeds of the following conventional and hybrid rice varieties were used in this study: indica hybrid rice Xieyou 92 (Xieqingzao/Hui 92) F 1 and Xieyou 46 (Xieqingzao A/Milyang 46) F 1 , the cytoplasmic male sterile line Xieqingzao A, the DNA extraction DNA was extracted using a modified CTAB method PCR and products analysis PCR amplification of DNA fragments of the cry1Ab gene in transgenic rice and of the microsatellite within the Wx gene in hybrid rice were conducted using the DNA templates isolated by modified CTAB method and our own simplified protocol. The sequences of forward primer and reverse primer for the cry1Ab gene were 5'-TTCCTTGGACGAAATCCCACC-3' and 5'-GCCAGAATTGAACACATGAGCGC-3', targeting a fragment of 559 bp. The forward primer of SSR of Wx gene was 5'-CTTTGTCTATCTCAAGACAC-3' and the reverse primer 5'-TTGCAGATGTTCTTCCTGATG-3', which were designed according to Blight et a
Observation of an unusual field dependent slow magnetic relaxation and two distinct transitions in a family of new complexes
An unusual field dependent slow magnetic relaxation and two distinct
transitions were observed in a family of new rare earth-transition metal
complexes, [Ln (bipy) (HO) M(CN)] 1.5 (bipy) 4HO (bipy = 2,2'-bipyridine; Ln = Gd,Y; M = Fe,
Co). The novel magnetic relaxation, which is quite different from those
in normal spin glasses and superparamagnets but very resembles qualitatively
those in single-molecule magnet Mn-Ac even if they possess different
structures, might be attributed to the presence of frustration that is
incrementally unveiled by the external magnetic field. The two distinct
transitions in [GdFe] were presumed from DC and AC susceptibility as well as
heat capacity measurements.Comment: Revtex, 6 figure
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