3,6-Dibromo-9-(4-bromo­benz­yl)-9H-carbazole

The title compound, C19H12Br3N, was synthesized by N-alkyl­ation of 1-bromo-4-(bromo­meth­yl)benzene with 3,6-dibromo-9H-carbazole. There are two unique mol­ecules in the asymmetric unit. The carbazole ring system is essentially planar, with a mean deviation of 0.0402 Å for one mol­ecule and 0.0279 Å for the other. The carbazole planes are inclined to the benzene ring planes at dihedral angles of 58.3 (3) and 71.1 (3)° in the two mol­ecules

3,6-Dibromo-9-(4-chloro­benz­yl)-9H-carbazole

The title compound, C19H12Br2ClN, was synthesized by N-alkyl­ation of 1-chloro-4-(chloro­meth­yl)benzene with 3,6-dibromo-9H-carbazole. The carbazole ring system is essentially planar (mean deviation of 0.028 Å) and makes a dihedral angle of 74.6 (3)° with the plane of the benzene ring

The effect of oxidized low-density lipoprotein combined with adriamycin on the proliferation of Eca-109 cell line

<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to identify the affect on the proliferation Eca-109 cells treated with oxidized low-density lipoprotein (ox-LDL) combined with adriamycin (ADM).</p> <p>Methods</p> <p>Eca-109 cell were cultured in the presence of oxLDL/ADM, and cell proliferation tested by MTT and cell apoptosis was monitored by the proportion of apoptosis and cell cycle by flow cytomester. We simultaneously evaluated the level of associated- apoptosis Bcl-2, Bax, and Caspase-3 gene mRNA and protein.</p> <p>Results</p> <p>OxLDL were cytotoxic and activate apoptosis. OxLDL combined with ADM significant enhanced the proportion rate of apoptosis on a time and dose dependency. The expressions of the inhibiting apoptosis Bcl-2 gene mRNA and protein were down regulated, whereas, the expressions of the promoting apoptosis Bax, and Caspase-3 genes mRNA and protein were up regulation.</p> <p>Conclusion</p> <p>These results suggested that oxLDL have cytotoxicity and activate apoptosis on the Eca-109 cells. OxLDL combined with ADM have a synergistic effect on the apoptosis induced Eca-109 cells. Furthermore, oxLDL may contribute to the improvement of clinical chemotherapy of cancer need to make further investigation.</p

1α,6β,7β,11α,15β-Penta­hydr­oxy-7α,20-ep­oxy-ent-kaur-16-ene

The title compound, C20H30O6, a natural ent-kaurane diterpenoid, named nervosanin B, was obtained from the medicinal plant Isodon serra. It is composed of four rings with the expected trans and cis junctions. One of the six-membered rings is in a chair conformation, the other two are in boat conformations and the five-membered ring adopts an evenlope conformation. The mol­ecules stack along the a axis and are linked together by inter­molecular O—H⋯O hydrogen bonds. Two intramolecular O—H⋯O interactions also occur

Separation and economic recovery of strontium from Nanyishan oil-field water, China

The mass ratio of Ca to Sr is greater than 10 in Nanyishan oil-field water, which causes significant problems during the economic extraction and recovery of selected trace elements in the oil-field water. The oilfield water was isothermally evaporated and various salts such as Li, K, Mg, Ca, Na, Sr, Rb, Cs, Br, and I were obtained from the solution. The Sr content of each phase was determined by ICP-AES, the Sr distribution rule in this process was obtained, and the best separation stage for Sr was identified, to optimize the separation of Sr from Nanyishan oil-field water

A Wideband Waveguide Antenna with Nearly Equal E- and H-Plane Radiation Patterns

A novel wideband waveguide antenna with excellent performance is proposed, which is composed of a coaxial-waveguide transition and an open-ended rectangular waveguide loaded with a pair of horizontal umbrella-shaped metallic brims. The brims perpendicular to two broad walls of the waveguide are constructed to modulate the antenna to radiate nearly identical E- and H-plane radiation patterns. A wideband impedance matching performance is achieved with a fractional bandwidth of 40% through the introduction of short-stepped ladders. The antenna has the advantages of simple structure, symmetric radiation pattern, low-cross polarization, moderate back lobe, and almost constant beamwidth

Hilbert-Huang Transform analysis of quasi-periodic oscillations in MAXI J1820+070

We present time-frequency analysis, based on the Hilbert-Huang transform (HHT), of the evolution on the low-frequency quasi-periodic oscillations (LFQPOs) observed in the black hole X-ray binary MAXI J1820+070. Through the empirical mode decomposition (EMD) method, we decompose the light curve of the QPO component and measure its intrinsic phase lag between photons from different energy bands. We find that the QPO phase lag is negative (low energy photons lag behind high energy photons), meanwhile the absolute value of the lag increases with energy. By applying the Hilbert transform to the light curve of the QPO, we further extract the instantaneous frequency and amplitude of the QPO. Compared these results with those from the Fourier analysis, we find that the broadening of the QPO peak is mainly caused by the frequency modulation. Through further analysis, we find that these modulations could share a common physical origin with the broad-band noise, and can be well explained by the internal shock model of the jet

TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways

Primer Sequences used for RT-qPCR (5’ to 3’). (DOCX 13 kb